2. Immunology/Inflammation Vitamin D Related/Nuclear Receptor
  3. Glucocorticoid Receptor
  4. Hydrocortisone hemisuccinate sodium

Hydrocortisone hemisuccinate sodium  (Synonyms: 氢化可的松琥珀酸钠; Hydrocortisone 21-hemisuccinate sodium)

目录号: HY-B1402B 纯度: 99.66%
COA 产品使用指南

摩尔计算器

Hydrocortisone hemisuccinate sodium 是一种有口服活性的生理性糖皮质激素。Hydrocortisone hemisuccinate sodium 抑制 IL-6 和 IL-3 的生物活性，IC50 值分别为 6.7 和 21.4 μM。Hydrocortisone hemisuccinate sodium 可用于溃疡性结肠炎 (UC) 的研究。

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Hydrocortisone hemisuccinate sodium Chemical Structure

Hydrocortisone hemisuccinate sodium Chemical Structure

CAS No. : 125-04-2

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规格 价格 是否有货 数量
5 mg ￥164
In-stock
10 mg ￥263
In-stock
25 mg ￥500
In-stock
50 mg ￥700
In-stock
100 mg ￥900
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Hydrocortisone hemisuccinate sodium:

Hydrocortisone hemisuccinate sodium 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC)[1].

体外研究
(In Vitro)

Hydrocortisone hemisuccinate sodium inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells[3].
Hydrocortisone hemisuccinate sodium (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrocortisone hemisuccinate sodium 相关抗体:
体内研究
(In Vivo)

Hydrocortisone hemisuccinate sodium (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis[2]
Dosage: 30 mg/kg
Administration: P.o. twice daily for 5 days
Result: Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.
Increased the body weight.
分子量

484.51

Formula

C25H33NaO8
CAS 号
性状

固体

颜色

White to off-white

中文名称

氢化可的松琥珀酸钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 175 mg/mL (361.19 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0639 mL 10.3197 mL 20.6394 mL
5 mM 0.4128 mL 2.0639 mL 4.1279 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Hydrocortisone hemisuccinate sodium 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0639 mL 10.3197 mL 20.6394 mL 51.5985 mL
5 mM 0.4128 mL 2.0639 mL 4.1279 mL 10.3197 mL
10 mM 0.2064 mL 1.0320 mL 2.0639 mL 5.1599 mL
15 mM 0.1376 mL 0.6880 mL 1.3760 mL 3.4399 mL
20 mM 0.1032 mL 0.5160 mL 1.0320 mL 2.5799 mL
25 mM 0.0826 mL 0.4128 mL 0.8256 mL 2.0639 mL
30 mM 0.0688 mL 0.3440 mL 0.6880 mL 1.7200 mL
40 mM 0.0516 mL 0.2580 mL 0.5160 mL 1.2900 mL
50 mM 0.0413 mL 0.2064 mL 0.4128 mL 1.0320 mL
60 mM 0.0344 mL 0.1720 mL 0.3440 mL 0.8600 mL
80 mM 0.0258 mL 0.1290 mL 0.2580 mL 0.6450 mL
100 mM 0.0206 mL 0.1032 mL 0.2064 mL 0.5160 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hydrocortisone hemisuccinate125-04-2Hydrocortisone 21-hemisuccinate氢化可的松琥珀酸钠Glucocorticoid ReceptorHydrocortisone hemisuccinate sodiumGlucocorticoidUlcerative colitisInhibitorinhibitorinhibit

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