Nos1 - nitric oxide synthase 1 Gene

中文名称：一氧化氮合酶 1

种属: Rattus norvegicus

同用名: bNOS

关于 Nos1

功能概要

该基因编码的蛋白可启动多种功能，包括 ATPase 绑定活动；核苷酸结合活性；和过渡金属离子结合活性。参与多个过程，包括维持血管直径；调节阳离子跨膜运输；和神经元死亡的调节。位于多种细胞成分中，包括嗜苯胺青颗粒；核膜;和肌膜。部分含蛋白质复合物。在谷氨酸能突触和突触后密度、细胞内成分中具有活性。用于研究多种疾病，包括急性坏死性胰腺炎；脑缺血（多发）；晚期肾脏疾病;阳痿;和门静脉高压症。多种疾病的生物标志物，包括脑部疾病（多种）；心肌病（多发性）；高血压（多发性）；肾功能衰竭（多发）；和视网膜疾病（多种）。该基因的人类直系同源物与阿尔茨海默病有关；帕金森病；哮喘;囊性纤维化;和肥厚性幽门狭窄。与人 NOS1（一氧化氮合酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including blood vessel diameter maintenance; regulation of cation transmembrane transport; and regulation of neuron death. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]