NOS2 - nitric oxide synthase 2 Gene

中文名称：一氧化氮合酶 2

种属: Rattus norvegicus

同用名: iNos; Nos2a

关于 NOS2

功能概要

该基因编码的蛋白可启动多种功能，包括 HSP90 蛋白结合活性；连环蛋白结合活性；和酶结合活性。参与多个过程，包括G蛋白偶联受体信号通路偶联cGMP核苷酸第二信使；对细胞因子刺激的细胞反应；和对细菌的反应。在对细胞因子刺激的细胞反应和对有机环状化合物的细胞反应的上游或内部起作用。位于多个细胞成分中，包括细胞外空间；细胞质的核周区；和过氧化物酶体。用于研究多种疾病，包括阿尔茨海默病；糖尿病血管病;胸膜炎;肾性高血压;和中毒性休克综合症。多种疾病的生物标志物，包括急性坏死性胰腺炎；动脉疾病（多发性）；炎症性肠病（多发性）；肝病（多发性）；和肺部疾病（多种）。该基因的人类直系同源物与多种疾病有关，包括痴呆症（多种）；高血压（多发性）；疟疾;肺结核;和 2 型糖尿病。与人 NOS2（一氧化氮合酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including HSP90 protein binding activity; beta-catenin binding activity; and Enzyme binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; cellular response to cytokine stimulus; and response to bacterium. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]