Nos3 - nitric oxide synthase 3 Gene

中文名称：一氧化氮合酶 3

种属: Rattus norvegicus

同用名: eNos

关于 Nos3

功能概要

该基因编码的蛋白可启动多种功能，包括 HSP90 蛋白结合活性；连环蛋白结合活性；和钙调蛋白结合活性。参与多个过程，包括细胞对镁离子的反应；细胞对机械刺激的反应；和细胞对有机氮化合物的反应。位于几种细胞成分中，包括小窝；核仁;和肌膜。用于研究动脉疾病（多种）；肠易激综合症;缺血（多发）；肝病（多发性）；和视网膜疾病（多种）。多种疾病的生物标志物，包括动脉疾病（多种）；肾功能衰竭（多发）；肝病（多发性）；肺部疾病（多发）；和营养过剩（多种）。该基因的人类直系同源物与多种疾病有关，包括阿尔茨海默病（多种）；动脉疾病（多发性）；眼病（多发）；生殖器官癌（多发性）；和血管炎（多发性）。与人 NOS3（一氧化氮合酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including HSP90 protein binding activity; beta-catenin binding activity; and Calmodulin binding activity. Involved in several processes, including cellular response to magnesium ion; cellular response to mechanical stimulus; and cellular response to organonitrogen compound. Located in several cellular components, including caveola; nucleolus; and sarcolemma. Used to study artery disease (multiple); irritable bowel syndrome; ischemia (multiple); liver disease (multiple); and retinal disease (multiple). Biomarker of several diseases, including artery disease (multiple); kidney failure (multiple); liver disease (multiple); lung disease (multiple); and overnutrition (multiple). Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ Cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Apr 2022]