2. Gene
  3. TNFAIP8 - TNF alpha induced protein 8 Gene

TNFAIP8 - TNF alpha induced protein 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肿瘤坏死因子α诱导蛋白 8

种属: Homo sapiens

同用名: NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13

基因 ID: 25816 | 基因类型: protein coding

关于 TNFAIP8

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:119,268,759-119,399,688 (from NCBI)

This gene has 7 transcripts (splice variants), 131 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues.

功能概要

启用参与细胞凋亡过程的半胱氨酸型内肽酶抑制剂活性。参与细胞凋亡过程的正向调节。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNFAIP8 基因产物(6)

mRNA Protein Name
NM_001077654.3 NP_001071122.1 tumor necrosis factor alpha-induced protein 8 isoform b
NM_001286813.2 NP_001273742.1 tumor necrosis factor alpha-induced protein 8 isoform a
NM_001286814.1 NP_001273743.1 tumor necrosis factor alpha-induced protein 8 isoform c
NM_001286815.2 NP_001273744.1 tumor necrosis factor alpha-induced protein 8 isoform d
NM_001286817.2 NP_001273746.1 tumor necrosis factor alpha-induced protein 8 isoform d
NM_014350.4 NP_055165.2 tumor necrosis factor alpha-induced protein 8 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: 通过突变表型推断
10644768 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
10644768 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
14724590 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFAIP8 蛋白结构

DUF758

DUF758: Domain of unknown function (DUF758) (14 - 198)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

tumor necrosis factor alpha-induced protein 8

NF-kappa-B-inducible DED-containing protein

重组 TNFAIP8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76682 TNFAIP8 Protein, Human (His) O95379-1 (M1-I198) ≥95%

关联疾病

疾病名称 别名
Plantar Fasciitis

Fasciitis, Plantar
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14791 TNFAIP8 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14792 TNFAIP8L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14793 TNFAIP8L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14794 TNFAIP8L3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TNFAIP8 RGD RGD:1305908
Felis catus TNFAIP8 VGNC VGNC:102349
Bos taurus TNFAIP8 VGNC VGNC:36157
Mus musculus TNFAIP8 MGD MGI:2147191
Macaca mulatta TNFAIP8 VGNC VGNC:79068
Canis familiaris TNFAIP8 VGNC VGNC:47652
Others TNFAIP8 NCBI
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