TNFAIP8 - TNF alpha induced protein 8 Gene

中文名称：肿瘤坏死因子α诱导蛋白 8

种属: Homo sapiens

同用名: NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13

基因 ID: 25816 | 基因类型: protein coding

关于 TNFAIP8

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:119,268,759-119,399,688 (from NCBI)

This gene has 7 transcripts (splice variants), 131 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues.

功能概要

启用参与细胞凋亡过程的半胱氨酸型内肽酶抑制剂活性。参与细胞凋亡过程的正向调节。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNFAIP8 基因产物(6)

mRNA	Protein	Name
NM_001077654.3	NP_001071122.1	tumor necrosis factor alpha-induced protein 8 isoform b
NM_001286813.2	NP_001273742.1	tumor necrosis factor alpha-induced protein 8 isoform a
NM_001286814.1	NP_001273743.1	tumor necrosis factor alpha-induced protein 8 isoform c
NM_001286815.2	NP_001273744.1	tumor necrosis factor alpha-induced protein 8 isoform d
NM_001286817.2	NP_001273746.1	tumor necrosis factor alpha-induced protein 8 isoform d
NM_014350.4	NP_055165.2	tumor necrosis factor alpha-induced protein 8 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP IMP: 通过突变表型推断	10644768	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of apoptotic process	IMP IMP: 通过突变表型推断	10644768	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	14724590	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFAIP8 蛋白结构

DUF758

0
100
198 a.a.

蛋白主名

其他名称

tumor necrosis factor alpha-induced protein 8

NF-kappa-B-inducible DED-containing protein

TNFAIP8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TNFAIP8	O95379	ATN1	Homo sapiens	Q86V38	Y2H Prey Pooling	32296183
种属内	TNFAIP8	O95379	ATN1	Homo sapiens	Q86V38	Validated Y2H	32296183
种属内	TNFAIP8	O95379	ATN1	Homo sapiens	Q86V38	Y2H Array	32296183
种属内	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Pooling	16189514
种属内	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	25416956
种属内	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	25416956
种属内	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	32296183
种属内	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	32296183
种属内	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Array	32296183
种属内	TNFAIP8	O95379	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
种属内	TNFAIP8	O95379	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
种属内	TNFAIP8	O95379	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
种属内	TNFAIP8	O95379	TIFA	Homo sapiens	Q96CG3	Validated Y2H	25416956
种属内	TNFAIP8	O95379	TIFA	Homo sapiens	Q96CG3	Y2H Array	25416956
种属内	TNFAIP8	O95379	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	25416956
种属内	TNFAIP8	O95379	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	32296183
种属内	TNFAIP8	O95379	PRR13	Homo sapiens	Q9NZ81	Y2H Array	25416956
种属内	TNFAIP8	O95379	PLEKHF1	Homo sapiens	Q96S99	Validated Y2H	32296183
种属内	TNFAIP8	O95379	PLEKHF1	Homo sapiens	Q96S99	Y2H Prey Pooling	32296183
种属内	TNFAIP8	O95379	PLEKHF1	Homo sapiens	Q96S99	Y2H Array	32296183
种属内	TNFAIP8	O95379	EAPP	Homo sapiens	Q56P03	Validated Y2H	32296183
种属内	TNFAIP8	O95379	EAPP	Homo sapiens	Q56P03	Y2H Array	32296183
种属内	TNFAIP8	O95379	EAPP	Homo sapiens	Q56P03	Y2H Prey Pooling	32296183
种属内	TNFAIP8	O95379	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183
种属内	TNFAIP8	O95379	INO80E	Homo sapiens	Q8NBZ0	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TNFAIP8 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76682	TNFAIP8 Protein, Human (His)	O95379-1 (M1-I198)	≥95%

TNFAIP8 抗体

目录号	产品名	应用	反应物种
HY-P81855	TNFAIP8 Antibody (YA1600)	WB, IP	Human

关联疾病

疾病名称

别名

Plantar Fasciitis

Fasciitis, Plantar

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14791	TNFAIP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14792	TNFAIP8L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14793	TNFAIP8L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14794	TNFAIP8L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TNFAIP8	RGD	RGD:1305908
Felis catus	TNFAIP8	VGNC	VGNC:102349
Bos taurus	TNFAIP8	VGNC	VGNC:36157
Mus musculus	TNFAIP8	MGD	MGI:2147191
Macaca mulatta	TNFAIP8	VGNC	VGNC:79068
Canis familiaris	TNFAIP8	VGNC	VGNC:47652
Others	TNFAIP8	NCBI

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