POLR1A - RNA polymerase I subunit A Gene

中文名称：RNA 聚合酶 I 亚基 A

种属: Homo sapiens

同用名: A190; RPA1; RPO14; AFDCIN; RPA190; RPA194; RPO1-4

基因 ID: 25885 | 基因类型: protein coding

关于 POLR1A

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:86,020,216-86,105,886 (from NCBI)

This gene has 15 transcripts (splice variants), 212 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 5.9), endometrium (RPKM 5.1) and 25 other tissues.

功能概要

该基因编码的蛋白质是 RNA 聚合酶 I 复合物的最大亚基。编码的蛋白质代表复合物的催化亚基，它将 DNA 转录成核糖体 RNA 前体。该基因的缺陷是导致辛辛那提型肢端面部骨发育不全的原因。[RefSeq 提供，2016 年 5 月]

The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]

POLR1A 基因产物(1)

mRNA	Protein	Name
NM_015425.6	NP_056240.2	DNA-directed RNA polymerase I subunit RPA1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-directed 5'-3' RNA polymerase activity	IDA IDA: 通过直接分析推断	34671025	GOA
enables DNA/RNA hybrid binding	IDA IDA: 通过直接分析推断	34671025	GOA
enables RNA polymerase I activity	IMP IMP: 通过突变表型推断	23782956	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	26089203	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	34887565	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16514417	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	34671025	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of protein localization to nucleolus	IMP IMP: 通过突变表型推断	23782956	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of RNA polymerase I complex	IDA IDA: 通过直接分析推断	34671025	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLR1A 蛋白结构

RNA_pol_Rpb1_1

RNA_pol_Rpb1_2

RNA_pol_Rpb1_3

RNA_pol_Rpb1_4

RNA_pol_Rpb1_5

0
300
600
900
1200
1500
1720 a.a.

蛋白主名

其他名称

DNA-directed RNA polymerase I subunit RPA1

DNA-directed RNA polymerase I largest subunit

POLR1A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	POLR1A	O95602	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	POLR1A	O95602	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	POLR1A	O95602	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	POLR1A	O95602	REL	Homo sapiens	Q04864	Validated Y2H	25416956
种属内	POLR1A	O95602	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
种属内	POLR1A	O95602	REL	Homo sapiens	Q04864	Y2H Array	25416956
种属内	POLR1A	O95602	POLR1B	Homo sapiens	Q9H9Y6	Anti Bait CoIP	16514417
种属内	POLR1A	O95602	POLR1B	Homo sapiens	Q9H9Y6	Chromatography	19214185
种属内	POLR1A	O95602	POLR1B	Homo sapiens	Q9H9Y6	Anti Tag CoIP	26496610
种属内	POLR1A	O95602	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
种属内	POLR1A	O95602	ERBB2	Homo sapiens	P04626	Confocal	21555369
种属内	POLR1A	O95602	ERBB2	Homo sapiens	P04626	Anti Bait CoIP	21555369
种属内	POLR1A	O95602	DYDC2	Homo sapiens	Q96IM9	Y2H Prey Pooling	32296183
种属内	POLR1A	O95602	DYDC2	Homo sapiens	Q96IM9	Validated Y2H	32296183
种属内	POLR1A	O95602	DYDC2	Homo sapiens	Q96IM9	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Acrofacial Dysostosis, Cincinnati Type

Acrofacial Dysostosis Cincinnati Type	AFDCIN
Dysostosis, Acrofacial, Cincinnati Type

Burn-Mckeown Syndrome

Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome	Oculootofacial Dysplasia
BMKS	Oofd
Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance	Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome
Choanal Atresia Deafness Cardiac Defects Dysmorphism	Oculo-Oto-Facial Dysplasia

Acrofacial Dysostosis

Dysostosis

Dysostoses

Warsaw Breakage Syndrome

WABS

WBRS

Sweeney-Cox Syndrome

SWCOS

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Osteogenesis Imperfecta, Type Xii

Osteogenesis Imperfecta Type 12	OI12
Osteogenesis Imperfecta Type Xii	Oi, Type Xii
Osteogenesis Imperfecta 12	Oi Type Xii
Oi-Xii	Osteogenesis Imperfecta Sillence Type Iii

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10837	POLR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	POLR1A	VGNC	VGNC:81152
Macaca mulatta	POLR1A	VGNC	VGNC:76044
Canis familiaris	POLR1A	VGNC	VGNC:44788
Mus musculus	POLR1A	MGD	MGI:1096397
Bos taurus	POLR1A	VGNC	VGNC:33131
Rattus norvegicus	POLR1A	RGD	RGD:620824

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLR1A - RNA polymerase I subunit A Gene

关于 POLR1A

功能概要

POLR1A 基因产物(1)

POLR1A 蛋白结构

POLR1A 蛋白互作信息

关联疾病

直系同源

热门区域

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POLR1A - RNA polymerase I subunit A Gene

关于 POLR1A

功能概要

POLR1A 基因产物(1)

POLR1A 蛋白结构

POLR1A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z