1. Gene
  2. Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

Map3k8 - mitogen-activated protein kinase kinase kinase 8 Gene

中文名称:丝裂原活化蛋白激酶激酶激酶 8

种属: Mus musculus

同用名: Cot; Est; Estf; Tpl2; Tpl-2; c-COT; Cot/Tpl2

基因 ID: 26410 | 基因类型: protein coding

关于 Map3k8

Chromosome 18: 4,331,327-4,353,015 reverse strand.GRCm39:CM001011.3

This gene has 5 transcripts (splice variants), 199 orthologues, 35 paralogues and is associated with 34 phenotypes. Ubiquitous expression in spleen adult (RPKM 3.1), lung adult (RPKM 2.9) and 27 other tissues.

功能概要

预测该基因编码的蛋白可启动 MAP 激酶激酶活性。预计参与蛋白质磷酸化和信号转导。预测作用于免疫系统过程和磷酸化的上游或内部。预测位于胞质溶胶中。以多种结构表达,包括脂肪组织;肾上腺;消化系统;淋巴系统腺体;和生殖系统。与人 MAP3K8(丝裂原活化蛋白激酶激酶 8)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in protein phosphorylation and signal transduction. Predicted to act upstream of or within immune system process and phosphorylation. Predicted to be located in cytosol. Is expressed in several structures, including adipose tissue; adrenal gland; alimentary system; hemolymphoid system gland; and reproductive system. Orthologous to human MAP3K8 (mitogen-activated protein kinase kinase kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Map3k8 基因产物(1)

mRNA Protein Name
NM_007746.2 NP_031772.1 mitogen-activated protein kinase kinase kinase 8

Map3k8 蛋白结构

STKc_MAP3K8

STKc_MAP3K8: cd13995 (132 - 387)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 8

COT proto-oncogene serine/threonine-protein kinase

cancer Osaka thyroid oncogene

proto-oncogene c-Cot

serine/threonine-protein kinase cot

tumor progression locus 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Map3k8 NCBI NCBI:1326