2. Gene
  3. NUPR1 - nuclear protein 1, transcriptional regulator Gene

NUPR1 - nuclear protein 1, transcriptional regulator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核蛋白 1，转录调节因子

种属: Homo sapiens

同用名: P8; COM1

基因 ID: 26471 | 基因类型: protein coding

关于 NUPR1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,532,708-28,538,974 (from NCBI)

This gene has 3 transcripts (splice variants), 159 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 197.1), pancreas (RPKM 192.3) and 21 other tissues.

功能概要

启用 DNA 结合活性和转录共激活因子活性。参与多个过程，包括调节细胞分解代谢过程；调节前体代谢物和能量的产生；和程序性细胞死亡的调节。在细胞周期的负调节上游或负调节内起作用。位于细胞间桥；核质；和细胞质的核周区。蛋白质-DNA 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity and transcription coactivator activity. Involved in several processes, including regulation of cellular catabolic process; regulation of generation of precursor metabolites and energy; and regulation of programmed cell death. Acts upstream of or within negative regulation of cell cycle. Located in intercellular bridge; nucleoplasm; and perinuclear region of cytoplasm. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

NUPR1 基因产物(2)

mRNA Protein Name
NM_001042483.2 NP_001035948.1 nuclear protein 1 isoform a
NM_012385.3 NP_036517.1 nuclear protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding EXP
EXP: 通过实验结果推断
11056169 GOA
enables DNA binding IDA
IDA: 通过直接分析推断
11056169 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11940591 GOA
enables transcription coactivator activity IMP
IMP: 通过突变表型推断
11940591 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
20181828 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
16478804 GOA
involved in negative regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
20181828 GOA
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
20181828 GOA
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
20181828 GOA
acts upstream of or within negative regulation of cell cycle IMP
IMP: 通过突变表型推断
19723804 GOA
involved in negative regulation of glycolytic process IMP
IMP: 通过突变表型推断
30451898 GOA
involved in negative regulation of programmed necrotic cell death IMP
IMP: 通过突变表型推断
30451898 GOA
involved in positive regulation of cell cycle IDA
IDA: 通过直接分析推断
10092851 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
27031958 GOA
involved in positive regulation of oxidative phosphorylation IMP
IMP: 通过突变表型推断
30451898 GOA
involved in positive regulation of proteasomal protein catabolic process IMP
IMP: 通过突变表型推断
16300740 GOA
involved in regulation of response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
30451898 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16300740 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10092851 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16300740 GOA
part of protein-DNA complex IDA
IDA: 通过直接分析推断
11056169 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUPR1 蛋白结构

Phospho_p8

Phospho_p8: DNA-binding nuclear phosphoprotein p8 (20 - 77)

  • 0
  • 82 a.a.
蛋白主名 其他名称

nuclear protein 1

candidate of metastasis 1

NUPR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NUPR1 O60356 CAPN2 Homo sapiens P17655
Validated Y2H
32814053
Intra NUPR1 O60356 CAPN2 Homo sapiens P17655
Y2H Array
32814053
Intra NUPR1 O60356 CAPN2 Homo sapiens P17655
Y2H Pooling
32814053
Intra NUPR1 O60356 CFAP100 Homo sapiens Q494V2-2
Y2H Pooling
32814053
Intra NUPR1 O60356 CFAP100 Homo sapiens Q494V2-2
Validated Y2H
32814053
Intra NUPR1 O60356 CFAP100 Homo sapiens Q494V2-2
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0532A Trifluoperazine dihydrochloride 99.98% 否
HY-B0532 Trifluoperazine / 否
HY-B0532B Trifluoperazine dimaleate / 否
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111838A ZZW-115 hydrochloride Inducer 98.63% 否
HY-111838 ZZW-115 Activator / 否
HY-B0532AS Trifluoperazine-d3 dihydrochloride / 否
HY-RS09702 NUPR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NUPR1 VGNC VGNC:32369
Macaca mulatta NUPR1 VGNC VGNC:75493
Felis catus NUPR1 VGNC VGNC:63929
Rattus norvegicus NUPR1 RGD RGD:69363
Canis familiaris NUPR1 VGNC VGNC:54052
Mus musculus NUPR1 MGD MGI:1891834
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