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  2. EIF3K - eukaryotic translation initiation factor 3 subunit K Gene

EIF3K - eukaryotic translation initiation factor 3 subunit K Gene

中文名称:真核翻译起始因子 3 亚基 K

种属: Homo sapiens

同用名: M9; ARG134; PLAC24; PTD001; EIF3S12; HSPC029; MSTP001; PLAC-24; PRO1474; EIF3-p28

基因 ID: 27335 | 基因类型: protein coding

关于 EIF3K

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,619,188-38,636,954 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 209 orthologues. Ubiquitous expression in heart (RPKM 136.4), duodenum (RPKM 100.7) and 25 other tissues.

功能概要

700-kD 真核翻译起始因子 3 (eIF3) 是最大的 eIF,包含至少 12 个亚基,包括 EIF2S12。 eIF3 通过直接结合 40S 核糖体亚基并促进 40S 预起始复合物的形成,在翻译中发挥重要作用 (Mayeur 等人,2003 [PubMed 14519125]) 。[OMIM 提供,2008 年 3 月]

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]

EIF3K 基因产物(3)

mRNA Protein Name
NM_001300992.2 NP_001287921.1 eukaryotic translation initiation factor 3 subunit K isoform 2
NM_001308393.2 NP_001295322.1 eukaryotic translation initiation factor 3 subunit K isoform 3
NM_013234.4 NP_037366.1 eukaryotic translation initiation factor 3 subunit K isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
contributes to translation initiation factor activity IDA
IDA: 通过直接分析推断
17581632 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in translational initiation IDA
IDA: 通过直接分析推断
17581632 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of eukaryotic translation initiation factor 3 complex IDA
IDA: 通过直接分析推断
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: 通过物理相互作用推断
17322308 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

EIF3K 蛋白结构

CSN8_PSD8_EIF3K

CSN8_PSD8_EIF3K: CSN8/PSMD8/EIF3K family (62 - 200)

  • 0
  • 100
  • 200
  • 218 a.a.
蛋白主名 其他名称

eukaryotic translation initiation factor 3 subunit K

eIF-3 p28

EIF3K 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF3K Q9UBQ5 EIF3E Homo sapiens P60228 35271311
种属内
EIF3K Q9UBQ5 EIF3E Homo sapiens P60228 23623729
种属内
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262 18599441
种属内
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262
Y2H
21516116
种属内
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262 16189514
种属内
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262 32296183
种属内
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262 35271311
种属内
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262 23623729
种属内
EIF3K Q9UBQ5 EIF3L Homo sapiens Q9Y262 25416956
种属间
EIF3K Q9UBQ5 ORF Human immunodeficiency virus Q9Q2G4 22190034
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 EIF3K 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76901 EIF3K Protein, Human (sf9, His-GST) Q9UBQ5 (A2-Q218) ≥95%

关联疾病

疾病名称 别名
Cardiomyopathy, Familial Hypertrophic, 11

Hypertrophic Cardiomyopathy 11

CMH11

Cardiomyopathy, Hypertrophic, 11

Cardiomyopathy Familial Hypertrophic 11

Cardiomyopathy, Familial Hypertrophic 11

Cardiomyopathy, Hypertrophic, Familial, Type 11

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1

Digitotalar Dysmorphism

DA1A

Da1

Amcd1

Arthrogryposis, Distal, Type 2b4

Distal Arthrogryposis Type 1a

Arthrogryposis, Distal, Type 1

Arthrogryposis Multiplex Congenita Distal Type 1

Arthrogryposis Multiplex Congenita, Distal Type 1

Arthrogryposis Multiplex Congenita, Distal, Type I

Distal Arthrogryposis Type 1b

Arthrogryposis, Distal, 1a

Amc

Arthrogryposis Multiplex Congenita

Arthrogryposis, Distal, 2b4

DA2B4

Arthrogryposis Multiplex Congenita, Distal, Type 1

Arthrogryposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus EIF3K MGD MGI:1921080
Canis familiaris EIF3K VGNC VGNC:40277
Rattus norvegicus EIF3K RGD RGD:1309221
Macaca mulatta EIF3K VGNC VGNC:72102
Felis catus EIF3K VGNC VGNC:61785
Bos taurus EIF3K VGNC VGNC:28401
Others EIF3K NCBI