ANG - angiogenin Gene

中文名称：血管生成素

种属: Homo sapiens

同用名: ALS9; RAA1; HEL168; RNASE4; RNASE5

基因 ID: 283 | 基因类型: protein coding

关于 ANG

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,177-20,694,186 (from NCBI)

This gene has 3 transcripts (splice variants), 98 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 449.5), ovary (RPKM 29.5) and 2 other tissues.

功能概要

由该基因编码的蛋白质是 RNase A 超家族的成员，尽管它具有相对较弱的核糖核酸分解活性。这种蛋白质是新血管形成的有效介质，因此除了名称 RNase5 外，通常也称为血管生成素。这种蛋白质在与内皮细胞表面的肌动蛋白结合后诱导血管生成。这种蛋白质还在核仁中积累，在那里它刺激核糖体转录。在应激条件下，该蛋白质易位至胞质溶胶，在胞质溶胶中水解细胞 tRNA 并影响蛋白质合成。从前体蛋白上切下信号肽，产生成熟蛋白，该蛋白包含核定位信号、细胞结合基序和催化结构域。这种蛋白质已被证明具有神经营养和神经保护作用，成熟的蛋白质对某些细菌和真菌具有抗菌活性，包括肺炎链球菌和白色念珠菌。由于其对 rRNA 产生和血管生成的影响，该基因在细胞生长和肿瘤进展中起重要作用。该基因的突变与肌萎缩侧索硬化症 (ALS) 的进展有关。该基因和邻近的 RNase4 基因共享启动子和 5' 外显子，但每个基因随后剪接成一个不同的 3' 外显子，其中包含每个基因的完整编码区。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2020 年 7 月]

The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]

ANG 基因产物(6)

mRNA	Protein	Name
NM_001097577.3	NP_001091046.1	angiogenin precursor
NM_001145.4	NP_001136.1	angiogenin precursor
NM_001385271.1	NP_001372200.1	angiogenin precursor
NM_001385272.1	NP_001372201.1	angiogenin precursor
NM_001385273.1	NP_001372202.1	angiogenin precursor
NM_001385274.1	NP_001372203.1	angiogenin precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables RNA nuclease activity	IDA IDA: 通过直接分析推断	2424496	GOA
enables actin binding	IDA IDA: 通过直接分析推断	7679494	GOA
enables copper ion binding	IDA IDA: 通过直接分析推断	9245697	GOA
enables heparin binding	IDA IDA: 通过直接分析推断	10103013	GOA
enables peptide binding	IDA IDA: 通过直接分析推断	11782452	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	2742853	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	25372031	GOA
enables ribosome binding	IDA IDA: 通过直接分析推断	38718836	GOA
enables signaling receptor binding	IDA IDA: 通过直接分析推断	9122172	GOA
enables tRNA-specific ribonuclease activity	IDA IDA: 通过直接分析推断	19332886	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within angiogenesis	IDA IDA: 通过直接分析推断	8448182	GOA
involved in angiogenesis	IDA IDA: 通过直接分析推断	3470787	GOA
involved in angiogenesis	IMP IMP: 通过突变表型推断	2479414	GOA
involved in antibacterial humoral response	IDA IDA: 通过直接分析推断	12548285	GOA
involved in antifungal humoral response	IDA IDA: 通过直接分析推断	12548285	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	12548285	GOA
involved in cell migration	IMP IMP: 通过突变表型推断	17125737	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: 通过直接分析推断	12548285	GOA
involved in hematopoietic stem cell proliferation	IDA IDA: 通过直接分析推断	27518564	GOA
involved in innate immune response	IDA IDA: 通过直接分析推断	12548285	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: 通过直接分析推断	10103013	GOA
involved in negative regulation of translation in response to stress	IDA IDA: 通过直接分析推断	19332886	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: 通过直接分析推断	9122172	GOA
involved in positive regulation of phosphorylation	IDA IDA: 通过直接分析推断	17125737	GOA
involved in positive regulation of protein secretion	IDA IDA: 通过直接分析推断	2646638	GOA
involved in rRNA transcription	IDA IDA: 通过直接分析推断	27518564	GOA
involved in rRNA transcription	IMP IMP: 通过突变表型推断	15735021	GOA
involved in response to hormone	IDA IDA: 通过直接分析推断	10999833	GOA
involved in response to hypoxia	IDA IDA: 通过直接分析推断	10999833	GOA
involved in response to yeast	IDA IDA: 通过直接分析推断	12548285	GOA
involved in signaling	IDA IDA: 通过直接分析推断	2457905	GOA
involved in stress granule assembly	IDA IDA: 通过直接分析推断	20129916	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of angiogenin-PRI complex	IDA IDA: 通过直接分析推断	3470787	GOA
part of angiogenin-PRI complex	IPI IPI: 通过物理相互作用推断	3470787	GOA
located in basement membrane	IDA IDA: 通过直接分析推断	15166501	GOA
is active in cytoplasm	IDA IDA: 通过直接分析推断	23047679	GOA
located in cytoplasmic stress granule	IDA IDA: 通过直接分析推断	27518564	GOA
located in endocytic vesicle	IDA IDA: 通过直接分析推断	29748193	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	3663649	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	23047679	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10649442	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANG 蛋白结构

RnaseA

0
100
147 a.a.

蛋白主名

其他名称

angiogenin

RNase 5

ANG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ANG	P03950	RNH1	Homo sapiens	P13489	Affinity Techniques	10413501
种属内	ANG	P03950	RNH1	Homo sapiens	P13489	Anti Tag CoIP	33961781
种属内	ANG	P03950	RNH1	Homo sapiens	P13489	Anti Tag CoIP	28514442
种属内	ANG	P03950	PCNA	Homo sapiens	P12004	Imaging	28777577
种属内	ANG	P03950	PCNA	Homo sapiens	P12004	Anti Bait CoIP	28777577
种属内	ANG	P03950	PLAUR	Homo sapiens	Q03405	IF	24457100
种属内	ANG	P03950	PLAUR	Homo sapiens	Q03405	Anti Bait CoIP	24457100
种属内	ANG	P03950	PLAUR	Homo sapiens	Q03405	PLA	24457100
种属内	ANG	P03950	ACTN2	Homo sapiens	P35609	FRET	15737636

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ANG 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7503	Angiogenin Protein, Human	P03950 (Q25-P147)	≥95%
HY-P700644	Angiogenin Protein, Human (His)	P03950 (D26-P147)	≥95%

关联疾病

疾病名称

别名

Amyotrophic Lateral Sclerosis 9

Amyotrophic Lateral Sclerosis Type 9	ALS9
Sclerosis, Lateral, Amyotrophic, Type Type 9

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Lateral Sclerosis

Primary Lateral Sclerosis	Adult-Onset Primary Lateral Sclerosis
Adult-Onset Pls	Motor Neuron Disease
Pls	Pls - [Primary Lateral Sclerosis]
Lateral Spinal Sclerosis	Lateral Complete Paralysis
Lateral Incomplete Paralysis	Lateral Paralysis

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 4, Juvenile

Amyotrophic Lateral Sclerosis Type 4	ALS4
Amyotrophic Lateral Sclerosis 4	Dhmn With Upper Motor Neuron Signs
Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs	Neuronopathy, Distal Hereditary Motor, With Pyramidal Features
Als 4	Distal Hereditary Motor Neuropathy With Pyramidal Features
Amyotrophic Lateral Sclerosis Juvenile 4	Neuronopathy Distal Hereditary Motor With Pyramidal Features
Sclerosis, Lateral, Amyotrophic, Type Type 4

Bladder Cancer

Urinary Bladder Cancer	Bladder Carcinoma
Urinary Bladder Carcinoma	Bladder Neoplasm
Bladder Tumor	Cancer, Bladder
Malignant Neoplasm Of Urinary Bladder	Carcinoma Of Bladder
Bladder Cancer, Somatic	Tumor Of The Bladder
Carcinoma Of Urinary Bladder	Bladder Carcinoma Urinary
Cancer Of The Urinary Bladder	Cancer, Urinary Bladder
Malignant Bladder Neoplasm	Malignant Bladder Tumor
Neoplasm Of The Bladder	Neoplasm Of The Urinary Bladder
Tumor Of The Urinary Bladder	Urinary Bladder Neoplasm
BLC	Urothelial Carcinoma Of The Bladder
Bladder Tumors	Urinary Bladder Neoplasms
Bladder Cancer Nos	Vesical Cancer Nos
Malignant Neoplasm Of Bladder, Part Unspecified	Malignant Tumour Of Urinary Bladder
Primary Malignant Neoplasm Of Bladder

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive	Als6
Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia	Autosomal Recessive Amyotrophic Lateral Sclerosis 6
Sclerosis, Lateral, Amyotrophic, Type Type 6	Amyotrophic Lateral Sclerosis 6

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-13948	Angiotensin II human		99.98%	否
HY-13948A	Angiotensin II human acetate		99.81%	否
HY-B0561	Spironolactone		99.66%	是
HY-B0202	Irbesartan		99.68%	是
HY-13948B	Angiotensin II human TFA		99.88%	否
HY-B0935	Benzyl benzoate	Inhibitor	99.94%	是
HY-B0202A	Irbesartan hydrochloride		/	否
HY-B0202R	Irbesartan (Standard)		/	否

目录号	产品名	作用方式	纯度	是否罕见病
HY-P99116	Faricimab	Inhibitor	97.97%	否

目录号	产品名	作用方式	纯度	Phase
HY-P2983	Angiotensin-converting enzyme		/	Phase 4
HY-137455	Terevalefim	Activator	99.89%	Phase 3
HY-109041	Razuprotafib		≥98.0%	Phase 2

目录号	产品名	作用方式	纯度	Phase
HY-P99330	Vanucizumab	Inhibitor	95.00%	Phase 2
HY-P99510	Zansecimab	Inhibitor	95.00%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12403	Talfirastide		99.91%	是
HY-P0216	A 779	Antagonist	98.67%	否
HY-15477	YS-49		99.92%	否
HY-15778	AVE 0991	Agonist	99.29%	否
HY-P1236	Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse	Inhibitor	99.46%	否
HY-N0515	Ophiopogonin D		99.54%	否
HY-151483	TK-129	Inhibitor	≥98.0%	否
HY-15778A	AVE 0991 sodium salt	Agonist	99.22%	否
HY-N7665	Prosaikogenin G		96.12%	否
HY-12403A	Talfirastide acetate		99.87%	是
HY-P1415A	Norleual TFA		99.32%	否
HY-147243	Ansornitinib	Inhibitor	98.04%	否
HY-N2666	5α-Hydroxycostic acid	Inhibitor	95.03%	否
HY-135795	1-Cyclohexyl-3-dodecyl urea	Inhibitor	≥98.0%	否
HY-P1236A	Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA	Inhibitor	/	否
HY-15477A	YS-49 monohydrate		99.71%	否
HY-102093A	ZD 7155		/	否
HY-103247	EMD 66684	Antagonist	/	否
HY-121313	Embusartan	Antagonist	/	否
HY-129412	A-74273	Inhibitor	/	否
HY-131162	Chymase		/	否
HY-142694	DCN1-UBC12-IN-2	Inhibitor	/	否
HY-162729	LSD1-IN-34	Inhibitor	/	否
HY-163859	LSD1-IN-33	Inhibitor	/	否
HY-169026	DCN1-IN-2	Inhibitor	/	否
HY-B0202S2	Irbesartan-d6-1		/	否
HY-P1415	Norleual		/	否
HY-RS00684	ANG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-W717329	EC33	Inhibitor	/	否
HY-13948BS	Angiotensin II human-13C6,15N TFA		98.11%	否
HY-167886	GA 0113	Antagonist	/	否
HY-B0202AS	Irbesartan-d7 hydrochloride		/	否
HY-B0202S3	Irbesartan-d7		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ANG	RGD	RGD:1594539
Mus musculus	ANG	MGD	MGI:88022
Canis familiaris	ANG	NCBI	NCBI:102153970
Macaca fascicularis	ANG	NCBI	NCBI:102118768
Canis lupus familiaris	ANG	NCBI
Macaca mulatta	ANG	NCBI
Others	ANG	NCBI

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