2. Gene
  3. ANG - angiogenin Gene

ANG - angiogenin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血管生成素

种属: Homo sapiens

同用名: ALS9; RAA1; HEL168; RNASE4; RNASE5

基因 ID: 283 | 基因类型: protein coding

关于 ANG

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:20,684,177-20,694,186 (from NCBI)

This gene has 3 transcripts (splice variants), 98 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 449.5), ovary (RPKM 29.5) and 2 other tissues.

功能概要

由该基因编码的蛋白质是 RNase A 超家族的成员，尽管它具有相对较弱的核糖核酸分解活性。这种蛋白质是新血管形成的有效介质，因此除了名称 RNase5 外，通常也称为血管生成素。这种蛋白质在与内皮细胞表面的肌动蛋白结合后诱导血管生成。这种蛋白质还在核仁中积累，在那里它刺激核糖体转录。在应激条件下，该蛋白质易位至胞质溶胶，在胞质溶胶中水解细胞 tRNA 并影响蛋白质合成。从前体蛋白上切下信号肽，产生成熟蛋白，该蛋白包含核定位信号、细胞结合基序和催化结构域。这种蛋白质已被证明具有神经营养和神经保护作用，成熟的蛋白质对某些细菌和真菌具有抗菌活性，包括肺炎链球菌和白色念珠菌。由于其对 rRNA 产生和血管生成的影响，该基因在细胞生长和肿瘤进展中起重要作用。该基因的突变与肌萎缩侧索硬化症 (ALS) 的进展有关。该基因和邻近的 RNase4 基因共享启动子和 5' 外显子，但每个基因随后剪接成一个不同的 3' 外显子，其中包含每个基因的完整编码区。可变剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2020 年 7 月]

The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]

ANG 基因产物(6)

mRNA Protein Name
NM_001097577.3 NP_001091046.1 angiogenin precursor
NM_001145.4 NP_001136.1 angiogenin precursor
NM_001385271.1 NP_001372200.1 angiogenin precursor
NM_001385272.1 NP_001372201.1 angiogenin precursor
NM_001385273.1 NP_001372202.1 angiogenin precursor
NM_001385274.1 NP_001372203.1 angiogenin precursor

ANG 蛋白结构

RnaseA

RnaseA: Pancreatic ribonuclease (27 - 140)

  • 0
  • 100
  • 147 a.a.
蛋白主名 其他名称

angiogenin

RNase 5

重组 ANG 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7503 Angiogenin Protein, Human P03950 (Q25-P147) ≥95%
HY-P700644 Angiogenin Protein, Human (His) P03950 (D26-P147) ≥95%

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 9

Amyotrophic Lateral Sclerosis Type 9

ALS9

Sclerosis, Lateral, Amyotrophic, Type Type 9
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Lateral Sclerosis

Primary Lateral Sclerosis

Adult-Onset Primary Lateral Sclerosis

Adult-Onset Pls

Motor Neuron Disease

Pls

Pls - [Primary Lateral Sclerosis]

Lateral Spinal Sclerosis

Lateral Complete Paralysis

Lateral Incomplete Paralysis

Lateral Paralysis
Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia

FTD

Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism

Mstd

Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism

Fldem

Ftdp17

Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

Ddpac

Wilhelmsen-Lynch Disease

Wld

Ppnd

Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

Ftd-Als

Ftld

Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia
Amyotrophic Lateral Sclerosis 4, Juvenile

Amyotrophic Lateral Sclerosis Type 4

ALS4

Amyotrophic Lateral Sclerosis 4

Dhmn With Upper Motor Neuron Signs

Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs

Neuronopathy, Distal Hereditary Motor, With Pyramidal Features

Als 4

Distal Hereditary Motor Neuropathy With Pyramidal Features

Amyotrophic Lateral Sclerosis Juvenile 4

Neuronopathy Distal Hereditary Motor With Pyramidal Features

Sclerosis, Lateral, Amyotrophic, Type Type 4
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive

Als6

Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia

Autosomal Recessive Amyotrophic Lateral Sclerosis 6

Sclerosis, Lateral, Amyotrophic, Type Type 6

Amyotrophic Lateral Sclerosis 6
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (8)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13948 Angiotensin II human 99.98% 否
HY-13948A Angiotensin II human acetate 99.81% 否
HY-B0561 Spironolactone 99.66% 是
HY-B0202 Irbesartan 99.68% 是
HY-13948B Angiotensin II human TFA 99.88% 否
HY-B0935 Benzyl benzoate Inhibitor 99.94% 是
HY-B0202A Irbesartan hydrochloride / 否
HY-B0202R Irbesartan (Standard) / 否
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99116 Faricimab Inhibitor 97.97% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-P2983 Angiotensin-converting enzyme / Phase 4
HY-137455 Terevalefim Activator 99.89% Phase 3
HY-109041 Razuprotafib ≥98.0% Phase 2
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99330 Vanucizumab Inhibitor 95.00% Phase 2
HY-P99510 Zansecimab Inhibitor 95.00% Phase 2
Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12403 Talfirastide 99.91% 是
HY-P0216 A 779 Antagonist 98.59% 否
HY-15778 AVE 0991 Agonist 99.29% 否
HY-15477 YS-49 99.92% 否
HY-P1236 Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse Inhibitor 99.46% 否
HY-N0515 Ophiopogonin D 99.54% 否
HY-151483 TK-129 Inhibitor ≥98.0% 否
HY-15778A AVE 0991 sodium salt Agonist 98.75% 否
HY-N7665 Prosaikogenin G 96.12% 否
HY-12403A Talfirastide acetate 99.87% 是
HY-P1415A Norleual TFA 99.32% 否
HY-147243 Ansornitinib Inhibitor 98.04% 否
HY-N2666 5α-Hydroxycostic acid Inhibitor 95.03% 否
HY-135795 1-Cyclohexyl-3-dodecyl urea Inhibitor ≥98.0% 否
HY-P1236A Atrial Natriuretic Peptide (ANP) (1-28), rat, mouse TFA Inhibitor / 否
HY-15477A YS-49 monohydrate 99.56% 否
HY-102093A ZD 7155 / 否
HY-103247 EMD 66684 Antagonist / 否
HY-121313 Embusartan Antagonist / 否
HY-129412 A-74273 Inhibitor / 否
HY-131162 Chymase / 否
HY-142694 DCN1-UBC12-IN-2 Inhibitor / 否
HY-162729 LSD1-IN-34 Inhibitor / 否
HY-163859 LSD1-IN-33 Inhibitor / 否
HY-169026 DCN1-IN-2 Inhibitor / 否
HY-B0202S2 Irbesartan-d6-1 / 否
HY-P1415 Norleual / 否
HY-RS00684 ANG Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W717329 EC33 Inhibitor / 否
HY-13948BS Angiotensin II human-13C6,15N TFA 98.11% 否
HY-B0202AS Irbesartan-d7 hydrochloride / 否
HY-B0202S3 Irbesartan-d7 / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ANG RGD RGD:1594539
Mus musculus ANG MGD MGI:88022
Canis familiaris ANG NCBI NCBI:102153970
Macaca fascicularis ANG NCBI NCBI:102118768
Canis lupus familiaris ANG NCBI
Macaca mulatta ANG NCBI
Others ANG NCBI
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