1. Gene
  2. Mapkapk2 - MAPK activated protein kinase 2 Gene

Mapkapk2 - MAPK activated protein kinase 2 Gene

中文名称:MAPK 活化蛋白激酶 2

种属: Rattus norvegicus

基因 ID: 289014 | 基因类型: protein coding

关于 Mapkapk2

Primary_assembly 13: 42,513,762-42,560,457 reverse strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 238 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in Heart (RPKM 849.3), Muscle (RPKM 59.4) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动钙调蛋白结合活性;有丝分裂原活化蛋白激酶结合活性;和蛋白丝氨酸/苏氨酸激酶活性。预计参与多个过程,包括蛋白质磷酸化;基因表达的调节;和对脂多糖的反应。预计作用于内耳发育的上游或内耳发育; p38MAPK 级联;和基因表达的正调控。预计位于中心体和核质中。预计在细胞质和细胞核中有活性。与人 MAPKAPK2(MAPK 活化蛋白激酶 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable Calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein phosphorylation; regulation of gene expression; and response to lipopolysaccharide. Predicted to act upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk2 基因产物(1)

mRNA Protein Name
NM_178102.2 NP_835203.1 MAP kinase-activated protein kinase 2

Mapkapk2 蛋白结构

STKc_MAPKAPK2

STKc_MAPKAPK2: cd14170 (46 - 348)

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  • 386 a.a.
蛋白主名 其他名称

MAP kinase-activated protein kinase 2

mitogen-activated protein kinase-activated protein kinase 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mapkapk2 NCBI NCBI:9261