2. Gene
  3. Ctsk - cathepsin K Gene

Ctsk - cathepsin K Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组织蛋白酶 K

种属: Rattus norvegicus

基因 ID: 29175 | 基因类型: protein coding

关于 Ctsk

Primary_assembly 2: 183,058,569-183,069,550 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 240 orthologues, 27 paralogues and is associated with 16 phenotypes. Biased expression in Uterus (RPKM 264.), Testes (RPKM 141.3) and 9 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能，包括胶原蛋白结合活性；纤连蛋白结合活性；和蛋白多糖结合活性。参与骨吸收和膜内骨化。位于细胞外空间和溶酶体中。颅内动脉瘤和中耳炎的生物标志物。该基因的人类直系同源物与致密性发育不良有关。与人类 CTSK（组织蛋白酶 K）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including collagen binding activity; fibronectin binding activity; and proteoglycan binding activity. Involved in bone resorption and intramembranous ossification. Located in extracellular space and lysosome. Biomarker of intracranial aneurysm and otitis media. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (Cathepsin K). [provided by Alliance of Genome Resources, Apr 2022]

Ctsk 基因产物(1)

mRNA Protein Name
NM_031560.2 NP_113748.1 cathepsin K precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bone resorption IMP
IMP: 通过突变表型推断
10430032 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
23110133 RGD
involved in cellular response to zinc ion starvation IEP
IEP: 通过表达模式推断
21893222 RGD
involved in intramembranous ossification IEP
IEP: 通过表达模式推断
16193234 RGD
involved in mononuclear cell differentiation IEP
IEP: 通过表达模式推断
23110133 RGD
involved in proteolysis IDA
IDA: 通过直接分析推断
21893222 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
22576626 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
20818503 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
20818503 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
16261450 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ctsk 蛋白结构

Inhibitor_I29

Inhibitor_I29: smart00848 (25 - 84)

Peptidase_C1

Peptidase_C1: pfam00112 (114 - 326)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
蛋白主名 其他名称

cathepsin K

重组 Ctsk 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72158 Cathepsin K Protein, Rat (His) O35186 (V115-M329) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-143714 Cathepsin K inhibitor 2 Inhibitor / 否
HY-155960 SH491 / 否
HY-RS03337 CTSK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03338 Ctsk Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03339 Ctsk Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ctsk NCBI NCBI:1513
Mus musculus Ctsk NCBI NCBI:13038
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