2. Gene
  3. Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：erb-b2 受体酪氨酸激酶3

种属: Rattus norvegicus

同用名: nuc-ErbB3

基因 ID: 29496 | 基因类型: protein coding

关于 Erbb3

Primary_assembly 7: 996,225-1,015,525 reverse strand.mRatBN7.2:CM026980.1

This gene has 5 transcripts (splice variants), 280 orthologues, 54 paralogues and is associated with 44 phenotypes. Biased expression in Kidney (RPKM 239.), Liver (RPKM 25.8) and 7 other tissues.

功能概要

该基因编码的蛋白可启动神经调节蛋白结合活性和神经调节蛋白受体活性。参与多个过程，包括动物器官发育；细胞对胰岛素刺激的反应；积极调节葡萄糖输入。位于细胞核和突触后膜。慢性阻塞性肺病和正中神经病变的生物标志物。该基因的人类直系同源物与致死性先天性挛缩综合征 2 相关；肺腺癌；肺非小细胞癌；和神经元肠发育不良 A 型。与人 ERBB3（erb-b2 受体酪氨酸激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including animal organ development; cellular response to Insulin stimulus; and positive regulation of glucose import. Located in nucleus and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Erbb3 基因产物(1)

mRNA Protein Name
NM_017218.3 NP_058914.2 receptor tyrosine-protein kinase erbB-3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables neuregulin binding IMP
IMP: 通过突变表型推断
14711829 RGD
enables neuregulin receptor activity IMP
IMP: 通过突变表型推断
14711829 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in axonogenesis IEP
IEP: 通过表达模式推断
9030624 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
9389501 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
30813222 RGD
involved in circadian rhythm IEP
IEP: 通过表达模式推断
12454858 RGD
involved in epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
14711829 RGD
involved in mammary gland involution IEP
IEP: 通过表达模式推断
10653587 RGD
involved in positive regulation of D-glucose import IMP
IMP: 通过突变表型推断
14711829 RGD
involved in positive regulation of membrane permeability IMP
IMP: 通过突变表型推断
30813222 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18184445 RGD
involved in skeletal muscle tissue development IEP
IEP: 通过表达模式推断
8846777 RGD
involved in tongue development IEP
IEP: 通过表达模式推断
10908606 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in neuronal cell body IDA
IDA: 通过直接分析推断
16859650 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
7589796 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Erbb3 蛋白结构

Recep_L_domain

Recep_L_domain: pfam01030 (55 - 166)

Furin-like

Furin-like: pfam00757 (181 - 328)

Recep_L_domain

Recep_L_domain: pfam01030 (352 - 473)

GF_recep_IV

GF_recep_IV: pfam14843 (498 - 629)

TM_ErbB3

TM_ErbB3: cd12095 (637 - 673)

PKc_like

PKc_like: cl21453 (698 - 976)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1339 a.a.
蛋白主名 其他名称

receptor tyrosine-protein kinase erbB-3

avian erythroblastosis oncogene B 3

c-erbB-3

c-erbB3

proto-oncogene-like protein c-ErbB-3

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

重组 Erbb3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74892 HER3 Protein, Rat (HEK293, Fc) G3V6N1 (S20-H641) ≥95%

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-13050 Sapitinib Inhibitor 99.93% Phase 2
抗体抑制剂 (6)
目录号 产品名 作用方式
纯度 Phase
HY-P99275 Patritumab Inhibitor 98.95% Phase 3
HY-P99268 Seribantumab ≥95.0% Phase 2
HY-P99866 Duligotuzumab 97.93% Phase 2
HY-P99672 Istiratumab Inhibitor / Phase 2
HY-P99304 Lumretuzumab Inhibitor ≥99.0% Phase 1
HY-P99461 Barecetamab Inhibitor 97.96% Phase 1
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100848 TX1-85-1 Inhibitor 98.04% 否
HY-18609 PD158780 Inhibitor 99.56% 否
HY-W006886 Fmoc-(R)-2-(7-octenyl)Ala-OH / 否
HY-118998 TX2-121-1 Inhibitor / 否
HY-13050A Sapitinib fumarate Inhibitor / 否
HY-RS04469 ERBB3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04470 Erbb3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04471 Erbb3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-164548 WK88-1 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Erbb3 NCBI NCBI:2065
Mus musculus Erbb3 NCBI NCBI:13867
Macaca mulatta Erbb3 NCBI NCBI:711407
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