Erbb3 - erb-b2 receptor tyrosine kinase 3 Gene

中文名称：erb-b2 受体酪氨酸激酶3

种属: Mus musculus

同用名: Her3; Erbb-3; Erbb3r

关于 Erbb3

功能概要

预计该基因编码的蛋白具有多种功能，包括 ErbB-3 类受体结合活性；神经调节蛋白结合活性；和跨膜信号受体活性。作用于多个过程的上游或内部，包括神经系统发育；钙调神经磷酸酶-NFAT 信号级联的正调控；和心肌组织发育的正调节。位于顶端质膜和侧质膜。以多种结构表达，包括消化系统；心;神经系统;生殖系统;和感觉器官上皮。该基因的人类直系同源物与致死性先天性挛缩综合征 2 相关；肺腺癌；肺非小细胞癌；和神经元肠发育不良 A 型。与人 ERBB3（erb-b2 受体酪氨酸激酶 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cardiac muscle tissue development. Located in apical plasma membrane and lateral plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; reproductive system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]