2. Gene
  3. ADAM10 - ADAM metallopeptidase domain 10 Gene

ADAM10 - ADAM metallopeptidase domain 10 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶结构域 10

种属: Rattus norvegicus

同用名: MADM

基因 ID: 29650 | 基因类型: protein coding

关于 ADAM10

Primary_assembly 8: 71,345,837-71,477,889 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 371 orthologues, 29 paralogues and is associated with 20 phenotypes. Biased expression in Spleen (RPKM 367.5), Thymus (RPKM 291.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动金属内肽酶活性。涉及多个过程，包括淀粉样蛋白-β 的形成；树突棘形态发生的调节；和对抗肿瘤药物的反应。位于多个细胞成分中，包括树突棘；突触小泡；和跨高尔基网络。活跃于谷氨酸能突触和突触后。阿尔茨海默病的生物标志物；心肌病;白内障;癫痫持续状态；和胸主动脉瘤。该基因的人类直系同源物与阿尔茨海默病 18 和 Kitamura 的网状肢端色素沉着有关。与人类 ADAM10（ADAM 金属肽酶结构域 10）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables metalloendopeptidase activity. Involved in several processes, including amyloid-beta formation; regulation of dendritic spine morphogenesis; and response to antineoplastic agent. Located in several cellular components, including dendritic spine; synaptic vesicle; and trans-Golgi network. Is active in glutamatergic synapse and postsynapse. Biomarker of Alzheimer's disease; cardiomyopathy; cataract; status epilepticus; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10). [provided by Alliance of Genome Resources, Apr 2022]

ADAM10 基因产物(1)

mRNA Protein Name
NM_019254.1 NP_062127.1 disintegrin and metalloproteinase domain-containing protein 10 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metalloendopeptidase activity IDA
IDA: 通过直接分析推断
10423016 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta formation IMP
IMP: 通过突变表型推断
17301176 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
21503882 RGD
involved in regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
22328515 RGD
involved in response to antineoplastic agent IEP
IEP: 通过表达模式推断
21503882 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
25053185 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
21503882 RGD
located in dendrite IDA
IDA: 通过直接分析推断
25429624 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
17301176 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
17301176 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
25429624 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
17301176 RGD
located in postsynapse IDA
IDA: 通过直接分析推断
22328515 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
17301176 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
26296617 RGD
located in trans-Golgi network IDA
IDA: 通过直接分析推断
10423016 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADAM10 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: cl03265 (45 - 155)

ZnMc_TACE_like

ZnMc_TACE_like: cd04270 (220 - 459)

DISIN

DISIN: smart00050 (466 - 545)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 10

ADAM 10

RGD1566370

a disintegrin and metallopeptidase domain 10

a disintegrin and metalloprotease domain 10

kuzbanian protein homolog

mammalian disintegrin-metalloprotease

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-10293 Aderbasib Inhibitor 99.44% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-115670 GW280264X Inhibitor 98.28% 否
HY-110397 KP-457 Inhibitor 99.18% 否
HY-120852 JG26 Inhibitor 98.01% 否
HY-108675 PPNDS tetrasodium Inhibitor 96.39% 否
HY-P3722A Mca-PLAQAV-Dpa-RSSSR-NH2 TFA 99.21% 否
HY-P3722 Mca-PLAQAV-Dpa-RSSSR-NH2 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ADAM10 NCBI NCBI:102
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