2. Gene
  3. SNX10 - sorting nexin 10 Gene

SNX10 - sorting nexin 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：排序 nexin 10

种属: Homo sapiens

同用名: OPTB8

基因 ID: 29887 | 基因类型: protein coding

关于 SNX10

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,291,862-26,374,383 (from NCBI)

This gene has 27 transcripts (splice variants), 278 orthologues, 15 paralogues and is associated with 2 phenotypes. Broad expression in brain (RPKM 20.5), appendix (RPKM 13.4) and 19 other tissues.

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域，它是一个磷酸肌醇结合结构域，并参与细胞内运输。这种蛋白质不像某些家族成员那样包含卷曲螺旋区域。该基因可能在调节内体稳态中发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

SNX10 基因产物(8)

mRNA Protein Name
NM_001199835.1 NP_001186764.1 sorting nexin-10 isoform 1
NM_001199837.3 NP_001186766.1 sorting nexin-10 isoform 2
NM_001199838.2 NP_001186767.1 sorting nexin-10 isoform 3
NM_001318198.1 NP_001305127.1 sorting nexin-10 isoform 4
NM_001318199.3 NP_001305128.1 sorting nexin-10 isoform 1
NM_001362753.1 NP_001349682.1 sorting nexin-10 isoform 4
NM_001362754.1 NP_001349683.1 sorting nexin-10 isoform 4
NM_013322.3 NP_037454.2 sorting nexin-10 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 1-phosphatidylinositol binding IMP
IMP: 通过突变表型推断
17012226 GOA
enables ATPase binding IPI
IPI: 通过物理相互作用推断
21844891 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cilium assembly IMP
IMP: 通过突变表型推断
21844891 GOA
involved in endosome organization IMP
IMP: 通过突变表型推断
17012226 GOA
involved in protein localization to centrosome IMP
IMP: 通过突变表型推断
21844891 GOA
involved in protein localization to cilium IMP
IMP: 通过突变表型推断
21844891 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with centrosome IDA
IDA: 通过直接分析推断
21844891 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
22174188 GOA
located in extrinsic component of endosome membrane IDA
IDA: 通过直接分析推断
17012226 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22174188 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNX10 蛋白结构

PX

PX: PX domain (12 - 123)

  • 0
  • 100
  • 201 a.a.
蛋白主名 其他名称

sorting nexin-10

SNX10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SNX10 Q9Y5X0 PRKCA Homo sapiens P17252
Validated Y2H
32814053
种属内
SNX10 Q9Y5X0 PRKCA Homo sapiens P17252
Y2H Array
32814053
种属内
SNX10 Q9Y5X0 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
种属内
SNX10 Q9Y5X0 YIF1A Homo sapiens O95070
Y2H Array
32296183
种属内
SNX10 Q9Y5X0 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
种属内
SNX10 Q9Y5X0 YWHAG Homo sapiens P61981
Validated Y2H
32814053
种属内
SNX10 Q9Y5X0 YWHAG Homo sapiens P61981
Y2H Array
32814053
种属内
SNX10 Q9Y5X0 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
种属内
SNX10 Q9Y5X0 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
种属内
SNX10 Q9Y5X0 KAT5 Homo sapiens Q92993
Y2H Array
32814053
种属内
SNX10 Q9Y5X0 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
种属内
SNX10 Q9Y5X0 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
种属内
SNX10 Q9Y5X0 RABAC1 Homo sapiens Q9UI14
Y2H Array
32296183
种属内
SNX10 Q9Y5X0 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
种属内
SNX10 Q9Y5X0 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
种属内
SNX10 Q9Y5X0 ARL6IP1 Homo sapiens Q15041
Validated Y2H
25416956
种属内
SNX10 Q9Y5X0 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
种属内
SNX10 Q9Y5X0 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属内
SNX10 Q9Y5X0 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Osteopetrosis, Autosomal Recessive 8

Autosomal Recessive Osteopetrosis 8

OPTB8

Osteopetrosis, Autosomal Recessive, Type 8
Autosomal Recessive Malignant Osteopetrosis

Infantile Malignant Osteopetrosis
Osteopetrosis

Marble Bone Disease

Albers-Schonberg Disease

Osteopetroses

Marble Bones

Osteopetrosis And Related Disorders

Congenital Osteopetrosis

Marble Bone

Albers-Schoenberg Disease

Albers-Schonberg Osteopetrosis

Osteosclerosis Fragilis

Ivory Bones
Osteopetrosis, Autosomal Recessive 2

OPTB2

Autosomal Recessive Osteopetrosis 2

Osteopetrosis, Mild Autosomal Recessive Form

Osteoclast-Poor Osteopetrosis

Osteopetrosis, Osteoclast-Poor

Mild Autosomal Recessive Form Osteopetrosis

Osteopetrosis Autosomal Recessive 2

Autosomal Recessive Osteopetrosis Type 2

Osteopetrosis Osteoclast-Poor

Osteopetrosis, Autosomal Recessive, Type 2
Pycnodysostosis

Pyknodysostosis

PKND

Pycd

Toulouse-Lautrec Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-160477 DC-SX029 Inhibitor 98.07% 否
HY-RS13523 SNX10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SNX10 VGNC VGNC:77705
Bos taurus SNX10 VGNC VGNC:35091
Mus musculus SNX10 MGD MGI:1919232
Felis catus SNX10 VGNC VGNC:102706
Rattus norvegicus SNX10 RGD RGD:1305782
Canis familiaris SNX10 VGNC VGNC:46620
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