PKN3 - protein kinase N3 Gene

中文名称：蛋白激酶 N3

种属: Homo sapiens

同用名: UTDP4-1

基因 ID: 29941 | 基因类型: protein coding

关于 PKN3

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,702,503-128,720,916 (from NCBI)

This gene has 3 transcripts (splice variants), 291 orthologues and 9 paralogues. Ubiquitous expression in fat (RPKM 3.9), lung (RPKM 3.1) and 25 other tissues.

功能概要

预测启用蛋白质丝氨酸/苏氨酸激酶活性。参与上皮细胞迁移。预测位于高尔基体和细胞质中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein serine/threonine kinase activity. Involved in epithelial cell migration. Predicted to be located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

PKN3 基因产物(2)

mRNA	Protein	Name
NM_001317926.2	NP_001304855.1	serine/threonine-protein kinase N3 isoform 2
NM_013355.5	NP_037487.2	serine/threonine-protein kinase N3 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11432776	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in epithelial cell migration	IDA IDA: 通过直接分析推断	21754995	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PKN3 蛋白结构

HR1

Pkinase

Pkinase_C

0
200
400
600
800
889 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase N3

protein kinase PKN-beta

PKN3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PKN3	Q6P5Z2	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	PKN3	Q6P5Z2	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	PKN3	Q6P5Z2	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	PKN3	Q6P5Z2	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	PKN3	Q6P5Z2	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	PKN3	Q6P5Z2	ARHGAP26	Homo sapiens	Q9UNA1	Pull Down	32707033
Intra	PKN3	Q6P5Z2	ARHGAP26	Homo sapiens	Q9UNA1	Anti Tag CoIP	11432776
Intra	PKN3	Q6P5Z2	ARHGAP26	Homo sapiens	Q9UNA1	Y2H	11432776
Intra	PKN3	Q6P5Z2	ARHGAP10	Homo sapiens	A1A4S6	Pull Down	32707033
Intra	PKN3	Q6P5Z2	ARHGAP10	Homo sapiens	A1A4S6	Y2H	11432776
Intra	PKN3	Q6P5Z2	ARHGAP10	Homo sapiens	A1A4S6	Anti Tag CoIP	11432776
Intra	PKN3	Q6P5Z2	ARHGAP10	Homo sapiens	A1A4S6	Pull Down	11432776
Intra	PKN3	Q6P5Z2	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	PKN3	Q6P5Z2	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	PKN3	Q6P5Z2	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	PKN3	Q6P5Z2	PNMA1	Homo sapiens	Q8ND90	Y2H Array	32296183
Intra	PKN3	Q6P5Z2	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	32296183
Intra	PKN3	Q6P5Z2	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	32296183
Intra	PKN3	Q6P5Z2	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	PKN3	Q6P5Z2	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	PKN3	Q6P5Z2	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	PKN3	Q6P5Z2	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy	Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To
NAION	Non-Arteritic Anterior Ischemic Optic Neuropathy
Ischemic Optic Neuropathy	Aion
Optic Neuropathy, Ischemic	Naion, Susceptibility To
Optic Neuropathy, Anterior Ischemic	Optic Neuropathy, Anterior Ischemic, Susceptibility To
Non-Arteritic Anterior Ischaemic Optic Neuropathy	Nonarteritic Anterior Ischaemic Optic Neuropathy
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To	Ion - [Ischemic Optic Neuropathy]
Neuropathic Ischaemia Of N.Opticus	Ischaemic Neuropathy Of Optic Nerve

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour	Malignant Gastrointestinal Neuroendocrine Tumor
Malignant Gastrointestinal Neuroendocrine Tumour	Digestive System Neuroendocrine Neoplasm
Digestive System Neuroendocrine Tumor

Pachyonychia Congenita 1

Pachyonychia Congenita	Jadassohn-Lewandowsky Syndrome
Pachyonychia Congenita Syndrome	PC1
Pachyonychia Congenita, Jadassohn-Lewandowsky Type	Congenital Pachyonychia
Pachyonychia Congenita, Type 1	Pachyonychia Congenita, Jadassohn-Lewandowsky Type, Formerly
Jadassohn-Lewandowsky Syndrome, Formerly	Jackson-Lawler Type Pachyonychia Congenita
Pachyonychia Congenita Type 1	Jackson-Lawler Syndrome
Jadassohn-Lewandowski Syndrome	Pc
Pachyonychia Congenita Jackson-Lawler Type	Pachyonychia Congenita Jadassohn-Lewandowsky Type
Pachyonychia Congenita Jackson Lawler Type	Pc-1
Pachyonychia Congenita, Jadassohn Lewandowsky Type	Pachyonychia Congenita, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-148065	FMF-06-098-1		/	否
HY-153482	ATU027		/	否
HY-153482A	ATU027 sodium	Inhibitor	/	否
HY-RS10608	PKN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PKN3	RGD	RGD:1305921
Felis catus	PKN3	VGNC	VGNC:64195
Bos taurus	PKN3	VGNC	VGNC:32947
Canis familiaris	PKN3	VGNC	VGNC:44613
Macaca mulatta	PKN3	VGNC	VGNC:75824
Mus musculus	PKN3	MGD	MGI:2388285

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