2. Gene
  3. Lrrk2 - leucine-rich repeat kinase 2 Gene

Lrrk2 - leucine-rich repeat kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：富含亮氨酸重复激酶 2

种属: Rattus norvegicus

基因 ID: 300160 | 基因类型: protein coding

关于 Lrrk2

Primary_assembly 7: 122,826,696-122,987,703 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Biased expression in Lung (RPKM 24.9), Spleen (RPKM 172.7) and 8 other tissues.

功能概要

预计该基因编码的蛋白可启动多项功能，包括 GTP 绑定活动；细胞骨架蛋白结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与多个过程，包括神经系统发育；大分子代谢过程的正向调控；和小胶质细胞活化的正调节。位于多个细胞成分中，包括轴突；树突;和周核体。用于研究神经退行性疾病。糖尿病神经病变的生物标志物。该基因的人类直系同源物与克罗恩病有关；帕金森病；帕金森病 8；帕金森症；和癌症。与人类 LRRK2（富含亮氨酸重复激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and positive regulation of microglial cell activation. Located in several cellular components, including axon; dendrite; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 基因产物(1)

mRNA Protein Name
NM_001191789.2 NP_001178718.2 leucine-rich repeat serine/threonine-protein kinase 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
19879924 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
17114044 RGD
involved in neuron projection arborization IMP
IMP: 通过突变表型推断
17114044 RGD
involved in positive regulation of microglial cell activation IMP
IMP: 通过突变表型推断
22302802 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: 通过突变表型推断
22302802 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
18445495 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
22302802 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
20403420 RGD
involved in striatum development IEP
IEP: 通过表达模式推断
18272292 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
17114044 RGD
located in dendrite IDA
IDA: 通过直接分析推断
17114044 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
18445495 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
17114044 RGD
is active in presynaptic cytosol IDA
IDA: 通过直接分析推断
18445495 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Lrrk2 蛋白结构

LRR_RI

LRR_RI: sd00033 (983 - 1010)

PRK15370

PRK15370: cl33128 (1009 - 1257)

LRR_RI

LRR_RI: sd00033 (1011 - 1034)

LRR_RI

LRR_RI: sd00033 (1035 - 1057)

LRR_RI

LRR_RI: sd00033 (1058 - 1082)

LRR_RI

LRR_RI: sd00033 (1083 - 1106)

LRR_RI

LRR_RI: sd00033 (1107 - 1128)

LRR_RI

LRR_RI: sd00033 (1129 - 1172)

LRR_RI

LRR_RI: sd00033 (1173 - 1195)

LRR_RI

LRR_RI: sd00033 (1196 - 1219)

LRR_RI

LRR_RI: sd00033 (1220 - 1244)

RocCOR

RocCOR: cd09914 (1332 - 1505)

COR

COR: cl24610 (1525 - 1738)

STKc_LRRK2

STKc_LRRK2: cd14068 (1882 - 2133)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2526 a.a.
蛋白主名 其他名称

leucine-rich repeat serine/threonine-protein kinase 2

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-112809 GSK2646264 Inhibitor 98.39% Phase 1
Pre-clinical Phase
生物活性分子 (43)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100411 MLi-2 Inhibitor 99.80% 否
HY-13687 IKK 16 Inhibitor 99.88% 否
HY-10875 LRRK2-IN-1 Inhibitor 99.42% 否
HY-12477 PF-06447475 Inhibitor 99.94% 否
HY-15796 GNE0877 Inhibitor 99.81% 否
HY-148030 XL01126 Inhibitor 99.81% 否
HY-18163 GNE-7915 Inhibitor 99.82% 否
HY-13237 GSK2578215A Inhibitor 99.78% 否
HY-120085 PFE-360 Inhibitor 99.48% 否
HY-13488 HG-10-102-01 Inhibitor 99.55% 否
HY-13687A IKK 16 hydrochloride Inhibitor 99.95% 否
HY-15800A CZC-25146 Inhibitor 99.10% 否
HY-40294 Indazole Inhibitor 99.72% 否
HY-B0792 CZC-54252 Inhibitor 99.38% 否
HY-112855 PF-06454589 Inhibitor 99.91% 否
HY-12282 GNE-9605 Inhibitor 99.72% 否
HY-16936 JH-II-127 Inhibitor ≥98.0% 否
HY-142647 EB-42486 Inhibitor 99.62% 否
HY-163064 CC-3240 Inhibitor 98.23% 否
HY-111493 LRRK2 inhibitor 1 Inhibitor 99.93% 否
HY-152107 LRRK2-IN-7 Inhibitor 98.04% 否
HY-156429 MK-1468 Inhibitor / 否
HY-18163A GNE-7915 tosylate Inhibitor 99.69% 否
HY-145317 LRRK2-IN-2 Inhibitor / 否
HY-161571 LRRK2-IN-13 Inhibitor / 否
HY-158365 LRRK2-IN-14 Inhibitor / 否
HY-151444 LRRK2-IN-6 Inhibitor / 否
HY-168041 LRRK2-IN-15 Inhibitor / 否
HY-156167 LRRK2-IN-10 Inhibitor / 否
HY-155150 JH-XII-03-02 Inhibitor 99.41% 否
HY-153058 LRRK2-IN-8 Inhibitor / 否
HY-151441 LRRK2-IN-5 Inhibitor / 否
HY-148353 PF-06455943 Inhibitor / 否
HY-152107A (R,R)-LRRK2-IN-7 Inhibitor / 否
HY-161570 LRRK2-IN-12 Inhibitor / 否
HY-144074 LRRK2-IN-4 Inhibitor / 否
HY-145318 LRRK2-IN-3 Inhibitor / 否
HY-134562 PF-06371900 Inhibitor / 否
HY-162699 LY2023-001 Inhibitor / 否
HY-153103 LRRK2/NUAK1/TYK2-IN-1 Inhibitor / 否
HY-B0792A CZC-54252 hydrochloride Inhibitor 98.44% 否
HY-15800 CZC-25146 hydrochloride Inhibitor / 否
HY-P10636 Nictide / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lrrk2 NCBI NCBI:120892
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