1. Gene
  2. Atm - ATM serine/threonine kinase Gene

Atm - ATM serine/threonine kinase Gene

中文名称:ATM 丝氨酸/苏氨酸激酶

种属: Rattus norvegicus

基因 ID: 300711 | 基因类型: protein coding

关于 Atm

Primary_assembly 8: 53,831,093-53,932,437 reverse strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 226 orthologues, 5 paralogues and is associated with 113 phenotypes. Biased expression in Spleen (RPKM 259.9), Thymus (RPKM 189.4) and 9 other tissues.

功能概要

预测该基因编码的蛋白具有相同的蛋白质结合活性;磷酸转移酶活性,醇基作为受体;和蛋白质 N 末端结合活性。参与多个过程,包括神经元凋亡过程的正调控;氮化合物代谢过程的正向调控;和小胶质细胞活化的调节。位于细胞质和细胞核中。用于研究共济失调性毛细血管扩张症;细胞增殖疾病;不孕症;白血病;和淋巴瘤。癌前肿瘤和癫痫持续状态的生物标志物。该基因的人类直系同源物与多种疾病有关,包括结直肠癌;子宫内膜癌;肺癌(多发性);神经退行性疾病(多种);和老年性白内障。与人类 ATM(ATM 丝氨酸/苏氨酸激酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable identical protein binding activity; phosphotransferase activity, alcohol group as acceptor; and protein N-terminus binding activity. Involved in several processes, including positive regulation of neuron apoptotic process; positive regulation of nitrogen compound metabolic process; and regulation of microglial cell activation. Located in cytoplasm and nucleus. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atm 基因产物(1)

mRNA Protein Name
NM_001106821.1 NP_001100291.1 serine-protein kinase ATM
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
12915485 RGD
involved in DNA damage response IMP
IMP: 通过突变表型推断
19151707 RGD
involved in cellular response to ionizing radiation IMP
IMP: 通过突变表型推断
28007901 RGD
involved in positive regulation of DNA catabolic process IMP
IMP: 通过突变表型推断
27895165 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
20502937 RGD
involved in regulation of microglial cell activation IMP
IMP: 通过突变表型推断
28007901 RGD
involved in response to hypoxia IDA
IDA: 通过直接分析推断
16651613 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Atm 蛋白结构

TAN

TAN: pfam11640 (7 - 164)

FAT

FAT: pfam02259 (2136 - 2528)

PIKKc_ATM

PIKKc_ATM: cd05171 (2722 - 3001)

FATC

FATC: pfam02260 (3065 - 3094)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 3096 a.a.
蛋白主名 其他名称

serine-protein kinase ATM

Ataxia telangiectasia gene mutated in human beings

ataxia telangiectasia mutated homolog

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atm NCBI NCBI:472