ANXA1 - annexin A1 Gene

中文名称：膜联蛋白 A1

种属: Homo sapiens

同用名: ANX1; LPC1

基因 ID: 301 | 基因类型: protein coding

关于 ANXA1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:73,151,865-73,170,393 (from NCBI)

This gene has 8 transcripts (splice variants), 306 orthologues and 12 paralogues. Biased expression in esophagus (RPKM 2850.3), bone marrow (RPKM 574.5) and 4 other tissues.

功能概要

该基因编码一种结合磷脂的膜定位蛋白。这种蛋白质抑制磷脂酶 A2 并具有抗炎活性。已在多种肿瘤中检测到该基因的功能缺失或表达缺失。[RefSeq 提供，2014 年 12 月]

This gene encodes a membrane-localized protein that binds Phospholipids. This protein inhibits Phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]

ANXA1 基因产物(1)

mRNA	Protein	Name
NM_000700.3	NP_000691.1	annexin A1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	EXP EXP: 通过实验结果推断	11078886	GOA
enables calcium-dependent phospholipid binding	IDA IDA: 通过直接分析推断	2138016	GOA
enables calcium-dependent protein binding	IPI IPI: 通过物理相互作用推断	15226301	GOA
enables lipid binding	EXP EXP: 通过实验结果推断	8756690	GOA
enables phospholipase A2 inhibitor activity	IDA IDA: 通过直接分析推断	2936963	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20029029	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA IDA: 通过直接分析推断	25664854	GOA
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP IMP: 通过突变表型推断	15187149	GOA
involved in actin cytoskeleton organization	IDA IDA: 通过直接分析推断	15187149	GOA
involved in cellular response to glucocorticoid stimulus	IDA IDA: 通过直接分析推断	2936963	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: 通过直接分析推断	22773844	GOA
involved in granulocyte chemotaxis	IDA IDA: 通过直接分析推断	15187149	GOA
involved in keratinocyte differentiation	IDA IDA: 通过直接分析推断	10908733	GOA
involved in monocyte chemotaxis	IDA IDA: 通过直接分析推断	15187149	GOA
involved in negative regulation of T-helper 2 cell differentiation	IDA IDA: 通过直接分析推断	17008549	GOA
involved in negative regulation of exocytosis	IMP IMP: 通过突变表型推断	19625660	GOA
involved in negative regulation of interleukin-8 production	IMP IMP: 通过突变表型推断	22056994	GOA
involved in neutrophil activation	IDA IDA: 通过直接分析推断	22879591	GOA
involved in neutrophil clearance	IMP IMP: 通过突变表型推断	21957127	GOA
involved in neutrophil homeostasis	IMP IMP: 通过突变表型推断	21957127	GOA
involved in peptide cross-linking	IDA IDA: 通过直接分析推断	10908733	GOA
involved in positive regulation of T cell proliferation	IDA IDA: 通过直接分析推断	17008549	GOA
involved in positive regulation of T-helper 1 cell differentiation	IDA IDA: 通过直接分析推断	17008549	GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis	IDA IDA: 通过直接分析推断	22773844	GOA
involved in positive regulation of interleukin-2 production	IDA IDA: 通过直接分析推断	17008549	GOA
involved in positive regulation of vesicle fusion	IDA IDA: 通过直接分析推断	2138016	GOA
involved in positive regulation of wound healing	IDA IDA: 通过直接分析推断	25664854	GOA
involved in regulation of cell shape	IDA IDA: 通过直接分析推断	15187149	GOA
involved in regulation of hormone secretion	IMP IMP: 通过突变表型推断	19625660	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with actin filament	IDA IDA: 通过直接分析推断	22773844	GOA
located in cell surface	IDA IDA: 通过直接分析推断	22056994	GOA
located in cornified envelope	IDA IDA: 通过直接分析推断	10908733	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10772777	GOA
located in endosome	IDA IDA: 通过直接分析推断	18767904	GOA
located in extracellular exosome	IDA IDA: 通过直接分析推断	25664854	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	17008549	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10772777	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10772777	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANXA1 蛋白结构

Annexin

0
100
200
300
346 a.a.

蛋白主名

其他名称

annexin A1

annexin I (lipocortin I)

ANXA1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ANXA1	P04083	EVA1B	Homo sapiens	Q9NVM1	Y2H Pooling	32814053
种属内	ANXA1	P04083	EVA1B	Homo sapiens	Q9NVM1	Validated Y2H	32814053
种属内	ANXA1	P04083	EVA1B	Homo sapiens	Q9NVM1	Y2H Array	32814053
种属内	ANXA1	P04083	LNPK	Homo sapiens	Q9C0E8-2	Validated Y2H	32296183
种属内	ANXA1	P04083	LNPK	Homo sapiens	Q9C0E8-2	Y2H Array	32296183
种属内	ANXA1	P04083	LNPK	Homo sapiens	Q9C0E8-2	Y2H Prey Pooling	32296183
种属内	ANXA1	P04083	LEG1	Homo sapiens	Q6P5S2	Validated Y2H	32814053
种属内	ANXA1	P04083	LEG1	Homo sapiens	Q6P5S2	Y2H Pooling	32814053
种属内	ANXA1	P04083	LEG1	Homo sapiens	Q6P5S2	Y2H Array	32814053
种属内	ANXA1	P04083	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Array	32814053
种属内	ANXA1	P04083	ZHX1-C8orf76	Homo sapiens	Q96EF9	Validated Y2H	32814053
种属内	ANXA1	P04083	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Pooling	32814053
种属内	ANXA1	P04083	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
种属内	ANXA1	P04083	RIPK1	Homo sapiens	Q13546	Confocal	21383699
种属内	ANXA1	P04083	RIPK1	Homo sapiens	Q13546	GMS	21383699
种属内	ANXA1	P04083	IKBKG	Homo sapiens	Q9Y6K9	Anti Bait CoIP	21383699
种属内	ANXA1	P04083	IKBKG	Homo sapiens	Q9Y6K9	GMS	21383699
种属内	ANXA1	P04083	IKBKG	Homo sapiens	Q9Y6K9	Confocal	21383699

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ANXA1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7512	Annexin A1/ANXA1 Protein, Human	P04083 (A2-N346)	≥95%

ANXA1 抗体

目录号	产品名	应用	反应物种
HY-P80544	Annexin A1 Antibody (YA832)	WB	Human, Mouse, Rat, Monkey

关联疾病

疾病名称

别名

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Brain Edema

Cerebral Edema	Intracranial Swelling
Wet Brain

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Hairy Cell Leukemia

Hcl-V	Hairy Cell Leukemia Variant
Hairy Cell Leukaemia Variant	Hcl
Leukemic Reticuloendotheliosis	Leukemic Reticuloendotheliosis Variant
Prolymphocytic Variant Of Hcl	Prolymphocytic Variant Of Hairy Cell Leukemia
Leukemia Hairy Cell	Leukemia, Hairy Cell
Leukaemic Reticuloendotheliosis	Lre - [Leukemic Reticuloendotheliosis]
Hairy-Cell Leukaemia, Nos	Hcl - [Hairy Cell Leukaemia]
Hairy-Cell Leukaemia Without Mention Of Remission

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Spleen Cancer

Spleen Neoplasm	Splenic Neoplasm
Splenic Neoplasms	Malignant Splenic Tumor
Malignant Tumour Of Spleen	Tumor Of Spleen
Malignant Neoplasm Of Spleen

Splenic Marginal Zone Lymphoma

Smzl	Splenic Marginal Zone B-Cell Lymphoma

Fallopian Tube Clear Cell Adenocarcinoma

Clear Cell Carcinoma Of The Fallopian Tube

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Mucocele Of Appendix

Appendicele Mucocele	Appendicular Mucocele
Appendiceal Mucocele

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Myopathy

Muscular Diseases

Myopathies

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1098	Ac2-26	Inhibitor	99.14%	否
HY-P1098A	Ac2-26 TFA	Inhibitor	99.67%	否
HY-RS00757	ANXA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-P10275	Tat-NTS peptide	Inhibitor	/	否
HY-P10412	A11	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ANXA1	VGNC	VGNC:69944
Bos taurus	ANXA1	VGNC	VGNC:50196
Mus musculus	ANXA1	MGD	MGI:96819
Rattus norvegicus	ANXA1	RGD	RGD:2118
Felis catus	ANXA1	VGNC	VGNC:67681
Canis familiaris	ANXA1	VGNC	VGNC:37937
Macaca fascicularis	ANXA1	NCBI	NCBI:102144835
Canis lupus familiaris	ANXA1	NCBI
Others	ANXA1	NCBI

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