HAGH - hydroxyacylglutathione hydrolase Gene

中文名称：羟酰谷胱甘肽水解酶

种属: Homo sapiens

同用名: GLO2; GLX2; GLXII; HAGH1

基因 ID: 3029 | 基因类型: protein coding

关于 HAGH

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,807,629-1,827,194 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 47.0), liver (RPKM 45.0) and 25 other tissues.

功能概要

由该基因编码的酶被归类为硫酯酶，负责将 S-乳酰谷胱甘肽水解为还原型谷胱甘肽和 D-乳酸。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2013 年 10 月]

The Enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

HAGH 基因产物(5)

mRNA	Protein	Name
NM_001040427.2	NP_001035517.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 2
NM_001286249.2	NP_001273178.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 3 precursor
NM_001363912.1	NP_001350841.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 4 precursor
NM_001363914.1	NP_001350843.1	hydroxyacylglutathione hydrolase, mitochondrial isoform 5
NM_005326.6	NP_005317.2	hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables hydroxyacylglutathione hydrolase activity	IDA IDA: 通过直接分析推断	8550579	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in glutathione biosynthetic process	IDA IDA: 通过直接分析推断	8550579	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	15117945	GOA
located in mitochondrial matrix	IDA IDA: 通过直接分析推断	15117945	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HAGH 蛋白结构

Lactamase_B

0
100
200
308 a.a.

蛋白主名

其他名称

hydroxyacylglutathione hydrolase, mitochondrial

glyoxalase II

HAGH 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HAGH	Q16775	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
种属内	HAGH	Q16775	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HAGH 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71690	GLO2/Glyoxalase II Protein, Human (GST)	Q16775-1 (K50-D308)	≥95%

关联疾病

疾病名称

别名

Hydroxyacyl Glutathione Hydrolase Deficiency

Glyoxalase Ii Deficiency

Triosephosphate Isomerase Deficiency

TPID	Triose Phosphate-Isomerase Deficiency
Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency	Tpi Deficiency
Triose Phosphate Isomerase Deficiency	Deficiency Of Phosphotriose Isomerase
Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Encephalopathy, Ethylmalonic

Ethylmalonic Encephalopathy	EE
Epema Syndrome	Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Ethe1 Deficiency	Eme
Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05992	HAGH Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HAGH	VGNC	VGNC:41585
Mus musculus	HAGH	MGD	MGI:95745
Bos taurus	HAGH	VGNC	VGNC:29742
Felis catus	HAGH	VGNC	VGNC:67533
Rattus norvegicus	HAGH	RGD	RGD:2779
Macaca mulatta	HAGH	VGNC	VGNC:73343
Others	HAGH	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HAGH - hydroxyacylglutathione hydrolase Gene

关于 HAGH

功能概要

HAGH 基因产物(5)

HAGH 蛋白结构

HAGH 蛋白互作信息

重组 HAGH 蛋白

关联疾病

直系同源

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HAGH - hydroxyacylglutathione hydrolase Gene

关于 HAGH

功能概要

HAGH 基因产物(5)

HAGH 蛋白结构

HAGH 蛋白互作信息

重组 HAGH 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z