2. Gene
  3. Kat2a - lysine acetyltransferase 2A Gene

Kat2a - lysine acetyltransferase 2A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：赖氨酸乙酰转移酶2A

种属: Rattus norvegicus

同用名: Gcn5; Gcn5l2

基因 ID: 303539 | 基因类型: protein coding

关于 Kat2a

Primary_assembly 10: 85,632,216-85,640,166 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 209 orthologues, 11 paralogues and is associated with 4 phenotypes. Biased expression in Brain (RPKM 66.2), Adrenal (RPKM 57.9) and 9 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性和蛋白磷酸酶结合活性。参与多个过程，包括α-微管蛋白乙酰化；线粒体的细胞内分布；和心肌细胞分化的正调节。位于染色质和细胞核中。与人 KAT2A（赖氨酸乙酰转移酶 2A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity and protein Phosphatase binding activity. Involved in several processes, including alpha-tubulin acetylation; intracellular distribution of mitochondria; and positive regulation of cardiac muscle cell differentiation. Located in chromatin and nucleus. Orthologous to human KAT2A (lysine acetyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Kat2a 基因产物(1)

mRNA Protein Name
NM_001107050.1 NP_001100520.1 histone acetyltransferase KAT2A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
21697636 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17334388 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
15496412 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in alpha-tubulin acetylation IMP
IMP: 通过突变表型推断
20691906 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: 通过表达模式推断
15496412 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
20130956 RGD
involved in intracellular distribution of mitochondria IMP
IMP: 通过突变表型推断
19542216 RGD
involved in positive regulation of cardiac muscle cell differentiation IMP
IMP: 通过突变表型推断
20835911 RGD
involved in positive regulation of cell projection organization IMP
IMP: 通过突变表型推断
20691906 RGD
involved in protein modification process IMP
IMP: 通过突变表型推断
20835911 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
21697636 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
24614236 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
20130956 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Kat2a 蛋白结构

PCAF_N

PCAF_N: pfam06466 (80 - 329)

COG5076

COG5076: cl34891 (487 - 827)

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (727 - 826)

  • 0
  • 200
  • 400
  • 600
  • 833 a.a.
蛋白主名 其他名称

histone acetyltransferase KAT2A

GCN5 general control of amino acid synthesis-like 2

K(lysine) acetyltransferase 2A

general control of amino acid synthesis 5-like 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07074 KAT2A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07075 Kat2a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07076 Kat2a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kat2a NCBI NCBI:2648
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