2. Gene
  3. HGFAC - HGF activator Gene

HGFAC - HGF activator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：HGF 激活因子

种属: Homo sapiens

同用名: HGFA

基因 ID: 3083 | 基因类型: protein coding

关于 HGFAC

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:3,441,005-3,449,486 (from NCBI)

This gene has 4 transcripts (splice variants), 232 orthologues and 16 paralogues. Restricted expression toward liver (RPKM 27.9).

功能概要

该基因编码肽酶 S1 蛋白家族的一个成员。编码的蛋白质首先被合成为无活性的单链前体，然后通过内切蛋白水解加工被激活为异二聚体形式。它作为丝氨酸蛋白酶将肝细胞生长因子转化为活性形式。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

HGFAC 基因产物(2)

mRNA Protein Name
NM_001297439.2 NP_001284368.1 hepatocyte growth factor activator isoform 1 preproprotein
NM_001528.4 NP_001519.1 hepatocyte growth factor activator isoform 2 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15713485 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HGFAC 蛋白结构

fn2

fn2: Fibronectin type II domain (108 - 148)

EGF

EGF: EGF-like domain (164 - 195)

fn1

fn1: Fibronectin type I domain (202 - 237)

EGF

EGF: EGF-like domain (245 - 276)

Kringle

Kringle: Kringle domain (286 - 367)

Trypsin

Trypsin: Trypsin (408 - 641)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
蛋白主名 其他名称

hepatocyte growth factor activator

HGFAC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HGFAC Q04756 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
种属内
HGFAC Q04756 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
种属内
HGFAC Q04756 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
种属内
HGFAC Q04756 VSIG1 Homo sapiens Q86XK7
Y2H Prey Pooling
32296183
种属内
HGFAC Q04756 VSIG1 Homo sapiens Q86XK7
Validated Y2H
32296183
种属内
HGFAC Q04756 VSIG1 Homo sapiens Q86XK7
Y2H Array
32296183
种属内
HGFAC Q04756 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
种属内
HGFAC Q04756 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
种属内
HGFAC Q04756 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
种属内
HGFAC Q04756 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
种属内
HGFAC Q04756 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
种属内
HGFAC Q04756 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
种属内
HGFAC Q04756 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
种属内
HGFAC Q04756 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
种属内
HGFAC Q04756 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HGFAC 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76380 HGFA/HGF Activator Protein, Human (HEK293, His) Q04756/NP_001519.1 (Q36-S655) ≥95%

关联疾病

疾病名称 别名
Deafness, Autosomal Recessive 97

DFNB97

Autosomal Recessive Nonsyndromic Deafness 97

Autosomal Recessive Deafness 97

Deafness, Autosomal Recessive, 97

Deafness, Autosomal Recessive, Type 97
Malignant Peripheral Nerve Sheath Tumor

Mpnst

Malignant Neurilemmoma

Neurofibrosarcoma

Malignant Neurofibroma

Malignant Schwannoma

Neurogenic Sarcoma

Schwannoma, Malignant

Malignant Neoplasm Of The Peripheral Nerve Sheath

Malignant Peripheral Nerve Sheath Tumors
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06153 HGFAC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HGFAC VGNC VGNC:73374
Mus musculus HGFAC MGD MGI:1859281
Bos taurus HGFAC VGNC VGNC:53764
Felis catus HGFAC VGNC VGNC:67565
Rattus norvegicus HGFAC RGD RGD:70909
Canis familiaris HGFAC VGNC VGNC:41675
Macaca fascicularis HGFAC NCBI NCBI:102119847
Others HGFAC NCBI
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