2. Gene
  3. TNKS2 - tankyrase 2 Gene

TNKS2 - tankyrase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：端锚聚合酶2

种属: Rattus norvegicus

基因 ID: 309512 | 基因类型: protein coding

关于 TNKS2

Primary_assembly 1: 234,567,858-234,621,079 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 169 orthologues and 2 paralogues. Biased expression in Muscle (RPKM 716.3), Brain (RPKM 372.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质 N 末端结合活性。预计参与多个过程，包括蛋白质ADP-核糖基化；蛋白质定位于染色体、端粒区域；和端粒维护的调节。预计在生长调节的上游或调节范围内起作用。预计位于核包膜内；周围物质；和细胞质的核周区。预计在细胞质和细胞核中有活性。与人 TNKS2（端锚聚合酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein N-terminus binding activity. Predicted to be involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Predicted to act upstream of or within regulation of growth. Predicted to be located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNKS2 (tankyrase 2). [provided by Alliance of Genome Resources, Apr 2022]

TNKS2 基因产物(1)

mRNA Protein Name
NM_001107607.2 NP_001101077.2 poly [ADP-ribose] polymerase tankyrase-2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27441654 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNKS2 蛋白结构

PTZ00322

PTZ00322: cl31426 (26 - 112)

ANK

ANK: sd00045 (59 - 87)

PHA02876

PHA02876: cl31517 (72 - 457)

ANK

ANK: sd00045 (89 - 120)

ANK

ANK: sd00045 (122 - 153)

ANK

ANK: sd00045 (212 - 240)

ANK

ANK: sd00045 (242 - 273)

ANK

ANK: sd00045 (275 - 306)

ANK

ANK: sd00045 (364 - 396)

ANK

ANK: sd00045 (398 - 429)

ANK

ANK: sd00045 (432 - 520)

PHA03095

PHA03095: cl33707 (493 - 801)

ANK

ANK: sd00045 (527 - 555)

ANK

ANK: sd00045 (557 - 588)

ANK

ANK: sd00045 (590 - 621)

ANK

ANK: sd00045 (643 - 673)

ANK

ANK: sd00045 (680 - 708)

ANK

ANK: sd00045 (710 - 741)

ANK

ANK: sd00045 (743 - 774)

SAM_tankyrase1,2

SAM_tankyrase1,2: cd09524 (870 - 935)

tankyrase_like

tankyrase_like: cd01438 (937 - 1159)

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  • 1166 a.a.
蛋白主名 其他名称

poly [ADP-ribose] polymerase tankyrase-2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

tankyrase-2-like

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-12418 Stenoparib Inhibitor ≥98.0% Phase 2
Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15147 XAV-939 Inhibitor 99.91% 否
HY-12438 G007-LK Inhibitor 99.24% 否
HY-13990 NVP-TNKS656 99.66% 否
HY-16910 WIKI4 Inhibitor 99.93% 否
HY-12975 AZ6102 Inhibitor 99.65% 否
HY-13968 JW 55 Inhibitor 98.95% 否
HY-19351 MN-64 Inhibitor 99.61% 否
HY-U00422 K-756 Inhibitor 99.25% 否
HY-145267 OM-153 Inhibitor 99.59% 否
HY-148063 DB0614 98.80% 否
HY-123851 MSC2504877 Inhibitor 98.50% 否
HY-15811 XMD8-87 Inhibitor 98.15% 否
HY-101243 XMD16-5 Inhibitor 98.59% 否
HY-148061 DB1113 99.28% 否
HY-143338 ART-IN-1 Inhibitor 98.91% 否
HY-121719 TIQ-A Inhibitor 99.65% 否
HY-126248 Tankyrase-IN-2 Inhibitor 99.06% 否
HY-147886 PARP1-IN-11 Inhibitor 98.58% 否
HY-148065 FMF-06-098-1 / 否
HY-100847 AZ0108 Inhibitor / 否
HY-12601 TNKS 22 Inhibitor / 否
HY-145111 TNK2-IN-1 Inhibitor / 否
HY-145266 OM-1700 Inhibitor / 否
HY-146336 PARP1/2/TNKS1/2-IN-1 / 否
HY-153259 TNKS1/2-IN-2 Inhibitor / 否
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% 否
HY-23338 TNKS-2-IN-1 Inhibitor 95.77% 否
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-153332 Tankyrase-IN-5 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens TNKS2 NCBI NCBI:80351
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