2. Gene
  3. Tlr7 - toll-like receptor 7 Gene

Tlr7 - toll-like receptor 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Toll 样受体 7

种属: Rattus norvegicus

同用名: RGD1563357

基因 ID: 317468 | 基因类型: protein coding

关于 Tlr7

Primary_assembly X: 27,027,425-27,054,754 forward strand.mRatBN7.2:CM026994.1

This gene has 3 transcripts (splice variants), 197 orthologues, 26 paralogues and is associated with 16 phenotypes. Biased expression in Spleen (RPKM 25.2), Thymus (RPKM 42.9) and 7 other tissues.

功能概要

预测该基因编码的蛋白可启动 RNA 结合活性和模式识别受体活性。预计参与多个过程，包括细胞内信号转导；细胞因子产生的正调节；和对病毒的反应。预测作用于蛋白质磷酸化调节的上游或调节之内。预测定位于细胞质囊泡；内质网；和溶酶体。预计是受体复合体的一部分。预计在质膜上有活性。围产期坏死性小肠结肠炎的生物标志物。该基因的人类直系同源物与 COVID-19 和 X 连锁免疫缺陷 74 相关。与人类 TLR7（toll 样受体 7）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable RNA binding activity and pattern recognition receptor activity. Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of cytokine production; and response to virus. Predicted to act upstream of or within regulation of protein phosphorylation. Predicted to be located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Tlr7 基因产物(1)

mRNA Protein Name
NM_001097582.1 NP_001091051.1 toll-like receptor 7

Tlr7 蛋白结构

LRR_RI

LRR_RI: sd00033 (65 - 86)

LRR_8

LRR_8: pfam13855 (92 - 156)

LRR_RI

LRR_RI: sd00033 (108 - 145)

LRR_RI

LRR_RI: sd00033 (146 - 190)

LRR_RI

LRR_RI: sd00033 (191 - 222)

PLN00113

PLN00113: cl33413 (207 - 751)

LRR_RI

LRR_RI: sd00033 (223 - 243)

LRR_RI

LRR_RI: sd00033 (244 - 267)

LRR_RI

LRR_RI: sd00033 (268 - 308)

LRR_RI

LRR_RI: sd00033 (309 - 332)

LRR_RI

LRR_RI: sd00033 (333 - 358)

LRR_RI

LRR_RI: sd00033 (369 - 388)

LRR_RI

LRR_RI: sd00033 (389 - 415)

LRR_RI

LRR_RI: sd00033 (416 - 439)

LRR_RI

LRR_RI: sd00033 (514 - 536)

LRR_RI

LRR_RI: sd00033 (537 - 561)

LRR_RI

LRR_RI: sd00033 (562 - 585)

LRR_RI

LRR_RI: sd00033 (586 - 615)

LRR_RI

LRR_RI: sd00033 (616 - 638)

LRR_RI

LRR_RI: sd00033 (639 - 669)

LRR_RI

LRR_RI: sd00033 (670 - 694)

LRR_RI

LRR_RI: sd00033 (695 - 718)

LRR_RI

LRR_RI: sd00033 (719 - 742)

LRR_8

LRR_8: cl38440 (742 - 785)

LRR_RI

LRR_RI: sd00033 (767 - 785)

TIR

TIR: smart00255 (908 - 1053)

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  • 1068 a.a.
蛋白主名 其他名称

toll-like receptor 7

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0180 Imiquimod Agonist 99.96% 是
HY-B1370 Hydroxychloroquine sulfate Inhibitor 99.99% 是
HY-B0180A Imiquimod hydrochloride Agonist 99.77% 是
HY-B0180B Imiquimod maleate Agonist 99.25% 是
HY-B1370A (S)-Hydroxychloroquine Inhibitor / 否
HY-B1370B (R)-Hydroxychloroquine Inhibitor / 否
Clinical Phase
生物活性分子 (10)
目录号 产品名 作用方式
纯度 Phase
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-134581 Enpatoran Inhibitor 99.77% Phase 2
HY-134581A Enpatoran hydrochloride Inhibitor 99.33% Phase 2
HY-118250 GSK2245035 Agonist 99.85% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-100176 PF-4878691 Agonist 99.89% Phase 2
HY-111269 AZD8848 Agonist 99.14% Phase 2
HY-13655A Isatoribine Agonist / Phase 2
HY-109104 Telratolimod Agonist 98.98% Phase 1
HY-111786 LHC-165 Agonist ≥98.0% Phase 1
Pre-clinical Phase
生物活性分子 (65)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0201 Atractylenolide I Antagonist 99.94% 否
HY-124603 AT791 Inhibitor 98.77% 否
HY-128799 CL097 Agonist 99.89% 否
HY-103698A TLR7/8 agonist 1 dihydrochloride Agonist 99.70% 否
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% 否
HY-103697A Gardiquimod diTFA Agonist ≥99.0% 否
HY-108472 Loxoribine Agonist 99.64% 是
HY-103697 Gardiquimod Agonist 99.91% 否
HY-103698 TLR7/8 agonist 1 Agonist 97.33% 否
HY-12756A E6446 dihydrochloride Antagonist 99.96% 否
HY-135905 CL264 Inhibitor 98.63% 否
HY-110120 DSR-6434 Agonist 99.55% 否
HY-130797 TLR7/8 agonist 3 Agonist 99.96% 否
HY-150736 ODN 20844 Inhibitor / 否
HY-117602 TLR7 agonist 3 Agonist 99.90% 否
HY-131945 CU-115 Antagonist 99.55% 否
HY-139017 TLR7/8 agonist 4 Agonist 99.04% 否
HY-115400 1V209 Agonist 99.67% 否
HY-160229 ssRNA40 sodium Activator 93.25% 否
HY-10018 Toll-like receptor modulator Modulator 99.36% 否
HY-12756 E6446 Antagonist ≥98.0% 否
HY-153071 TLR7 agonist 6 Agonist 98.08% 否
HY-13740S Resiquimod-d5 Agonist 99.84% 否
HY-111358 TLR7 agonist 1 Agonist 98.95% 否
HY-110207 SM-324405 Agonist 98.52% 否
HY-128799A CL097 hydrochloride Agonist 99.51% 否
HY-150158 TMX-201 ≥95.0% 否
HY-157793 SMU-L11 Agonist 99.64% 否
HY-111582 BBIQ Agonist 99.85% 否
HY-160227A ORN 06 sodium Activator 90.78% 否
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% 否
HY-145961 TLR7 agonist 4 Agonist 98.87% 否
HY-150744 ODN 24888 Inhibitor / 否
HY-156174 E104 Inhibitor / 否
HY-153543 TLR7/8 agonist 8 Agonist / 否
HY-159102 PVP-037.2 Agonist / 否
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% 否
HY-138139A AXC-715 hydrochloride Agonist 99.46% 否
HY-139575 Guretolimod Agonist / 否
HY-147215 UC-1V150 Agonist / 否
HY-141454 TLR8 agonist 2 Agonist / 否
HY-141454A TLR8 agonist 2 hydrochloride Agonist / 否
HY-139017A TLR7/8 agonist 4 TFA Agonist / 否
HY-163398 TLR7-IN-1 Inhibitor / 否
HY-168157 TLR7 agonist 26 Agonist / 否
HY-152726 TLR7 agonist 9 Agonist / 否
HY-153070 TLR7 agonist 5 Agonist / 否
HY-162115 TLR7 agonist 17 Agonist / 否
HY-163670 TLR7 agonist 21 Inhibitor / 否
HY-156175 TLR7 agonist 14 Agonist / 否
HY-160227 ORN 06 Activator / 否
HY-158694 TLR7 agonist 20 Agonist / 否
HY-162845 TLR7/8 agonist 11 Agonist / 否
HY-168159 TLR7 agonist 27 Agonist / 否
HY-169057 BI1543673 Inhibitor / 否
HY-153073 TLR7 agonist 8 Agonist / 否
HY-153072 TLR7 agonist 7 Agonist / 否
HY-169017 MTT5 Agonist / 否
HY-162725 TLR7 agonist 24 Agonist / 否
HY-B1370R Hydroxychloroquine sulfate (Standard) Inhibitor / 否
HY-121496 3M-011 Agonist / 否
HY-159914 AYK004-B1 Agonist / 否
HY-159919 UM-3006 Agonist / 否
HY-159916 AYK004 Agonist / 否
HY-111582G BBIQ (GMP) Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tlr7 NCBI NCBI:51284
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