1. Gene
  2. TLR7 - toll like receptor 7 Gene

TLR7 - toll like receptor 7 Gene

中文名称:toll 样受体 7

种属: Homo sapiens

同用名: IMD74; SLEB17; TLR7-like

基因 ID: 51284 | 基因类型: protein coding

关于 TLR7

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,867,072-12,890,361 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues, 22 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 3.3), appendix (RPKM 3.0) and 23 other tissues.

功能概要

该基因编码的蛋白质是 Toll 样受体 (TLR) 家族的成员,该家族在病原体识别和先天免疫激活中起着重要作用。 TLR 从果蝇到人类高度保守,并具有结构和功能相似性。人类 TLR 家族包括 11 个成员。它们识别在传染原上表达的病原体相关分子模式 (PAMP) ,并介导产生有效免疫力所必需的细胞因子。对于外来微生物结构成分的识别,各种 TLRs 也表现出不同的表达模式;例如,通过这种方式,TLR-3、-7 和-8 在识别单链 RNA 病毒中必不可少。 TLR7 检测单链 RNA 寡核苷酸,其中含有来自 RNA 病毒的富含鸟苷和尿苷的序列,这种识别发生在浆细胞样树突状细胞和 B 细胞的核内体中。该基因主要在肺、胎盘和脾脏中表达,在系统发育上具有相关性,并且与 X 染色体上的另一个家族成员 TLR8 非常接近。[RefSeq 提供,2020 年 8 月]

The protein encoded by this gene is a member of the Toll-like Receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The human TLR family comprises 11 members. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. For the recognition of structural components in foreign Microorganisms, the various TLRs exhibit different patterns of expression as well; in this way for example, TLR-3, -7, and -8 are essential in the recognition of single-stranded RNA viruses. TLR7 senses single-stranded RNA Oligonucleotides containing guanosine- and uridine-rich sequences from RNA viruses, a recognition occuring in the endosomes of plasmacytoid dendritic cells and B cells. This gene is predominantly expressed in lung, placenta, and spleen, and is phylogenetically related and lies in close proximity to another family member, TLR8, on chromosome X. [provided by RefSeq, Aug 2020]

TLR7 基因产物(2)

mRNA Protein Name
NG_001066.3
NM_016562.4 NP_057646.1 toll-like receptor 7 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
16111635 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
33432245 GOA
enables single-stranded RNA binding IMP
IMP: 通过突变表型推断
35477763 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in I-kappaB phosphorylation IDA
IDA: 通过直接分析推断
19740627 GOA
involved in canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
35477763 GOA
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
involved in defense response to virus IEP
IEP: 通过表达模式推断
32634389 GOA
involved in defense response to virus IMP
IMP: 通过突变表型推断
16188996 GOA
involved in innate immune response IMP
IMP: 通过突变表型推断
35477763 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
12032557 GOA
involved in positive regulation of chemokine production IDA
IDA: 通过直接分析推断
19740627 GOA
involved in positive regulation of interferon-alpha production IDA
IDA: 通过直接分析推断
16286015 GOA
involved in positive regulation of interferon-beta production IDA
IDA: 通过直接分析推断
16286015 GOA
involved in positive regulation of interleukin-8 production IDA
IDA: 通过直接分析推断
19740627 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
16188996 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
19740627 GOA
involved in positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
16286015 GOA
involved in response to cGMP IMP
IMP: 通过突变表型推断
35477763 GOA
involved in toll-like receptor 7 signaling pathway IDA
IDA: 通过直接分析推断
12032557 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19740627 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19740627 GOA
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TLR7 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (275 - 324)

LRR_8

LRR_8: Leucine rich repeat (496 - 554)

LRR_1

LRR_1: Leucine Rich Repeat (651 - 672)

LRR_8

LRR_8: Leucine rich repeat (675 - 735)

LRR_1

LRR_1: Leucine Rich Repeat (748 - 770)

TIR

TIR: TIR domain (893 - 1027)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1049 a.a.
蛋白主名 其他名称

toll-like receptor 7

toll-like receptor 7-like

关联疾病

疾病名称 别名
Micronodular Basal Cell Carcinoma

Skin Micronodular Basal Cell Carcinoma

Basal Cell Carcinoma, Micronodular

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ehf

Ebola Fever

Ebola

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Actinic Keratosis

Solar Keratosis

Actinic Keratosis

Senile Hyperkeratosis

Sk - Solar Keratosis

Keratosis, Actinic

Seborrheic Keratosis

Ak - [Actinic Keratosis]

Sk - [Solar Keratosis]

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Parasitic Protozoa Infectious Disease

Protozoan Infections

Mastigophora Infectious Disease

Sarcomastigophora Infectious Disease

Systemic Lupus Erythematosus 17

SLEB17

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Encephalopathy With Basal Ganglia Calcification

Aicardi-Goutières Syndrome

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1

Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Pre-Malignant Neoplasm
Common Wart

Verruca Vulgaris

Viral Warts Nos

Filiform Warts

Digitate Warts

Autoimmune Disease Of Skin And Connective Tissue
Immune-Complex Glomerulonephritis

Immune Complex Glomerulonephritis

Skin Carcinoma

Skin Cancer

Carcinoma Of Skin

Ca - Skin Cancer

Cancer Of Skin

Malignant Neoplasm Of Skin

Melanoma And Non-Melanoma Skin Cancer

Skin Cancers

Cancer, Skin

Anaerobic Pneumonia

Pneumonia Due To Anaerobes

West Nile Encephalitis

West-Nile Encephalitis

West Nile Fever

West Nile Fever Encephalitis

West Nile Fever With Encephalitis

West-Nile Fever

Encephalitis, West Nile Fever

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Autoimmune Disease Of Exocrine System
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Immunodeficiency 74, Covid19-Related, X-Linked

Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

IMD74

Tlr7 Deficiency

Severe Covid-19
Respiratory Failure

Acute Respiratory Failure

Chronic Respiratory Failure

Respiratory Insufficiency

Acute-On-Chronic Respiratory Failure

Acute And Chronic Respiratory Failure

Respiratory Insufficiency/Failure

Chronic Respiratory Disease

Respiratory Disease

Pulmonary Valve Insufficiency

Chronic Disease Of Respiratory System

Respiration Disorders

Respiratory Tract Diseases

Lung Failure Nos

Pulmonary Failure

Arf - [Acute Respiratory Failure]

Acute Respiratory Insufficiency

Acute Pulmonary Insufficiency

Acute Respiration Failure

Chronic Respiration Failure

Primary Bacterial Infectious Disease
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Lyme Disease

Lyme Borreliosis

Lyme Neuroborreliosis

Borreliosis

Borrelia Burgdorferi Infection

Neuroborreliosis

Bannwarth Syndrome

Bannworth'S Syndrome

Neurological Lyme Disease

B. Burgdorferi Infection

Borreliosis, Lyme

Infection By Borrelia Burgdorferi

Infection Due To Borrelia Burgdorferi Sensu Lato

Lym

Borrelia Infections

Measles

Rubeola

Morbilli

Measles Nos

Koplik Spots

Superficial Basal Cell Carcinoma

Multifocal Superficial Basal Cell Carcinoma

Multicentric Basal Cell Carcinoma

Superficial Multicentric Basal-Cell Carcinoma

Herpangina

Vesicular Pharyngitis

Bronchiolitis
Genital Herpes

Herpes Genitalis

Genital Herpes Simplex

Venereal Herpes

Virus-Genital Herpes

Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Integumentary System Disease
Lymphadenitis

Acute Lymphadenitis

Chronic Lymphadenitis

Chronic Adenitis

Acute Adenitis

Adenitis

Inflammation Of Lymph Node

Adenitis Nos

Inflammation Of Gland

Lymphatic Gland Inflammation

Lymph Gland Inflammation

Polyadenitis

Chronic Adenitis Of Any Lymph Node Except Mesenteric

Chronic Lymphadenitis Except Mesenteric

Chronic Non-Specific Lymphadenitis

Skin Disease

Skin Diseases

Abnormality Of The Skin

Skin Diseases, Genetic

Genodermatosis

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

T Cell Deficiency

T Cell Immunodeficiency

T Lymphocyte Deficiency

T Lymphocyte Immunodeficiency

T-Lymphocyte Deficiency

Borst-Jadassohn Intraepidermal Carcinoma

Intraepidermal Epithelioma Of Jadassohn

Bowen'S Disease, Clonal

Autoimmune Disease Of Musculoskeletal System
Heart Block, Congenital

Congenital Heart Block

Heart Block Congenital

Congenital Atrioventricular Block

Mouth Disease

Mouth Diseases

Mouth Disorders

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1

Chromoblastomycosis

Chromomycosis

Mossy Foot Disease

Verrucous Dermatitis

Fonseca Disease

Pedroso Disease

Drechslera Hawaiiensis

Drechslera Infection

Coronavirus Infectious Disease
Subcutaneous Mycosis

Subcutaneous Fungal Disease

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

X-Linked Immunodeficiency 74

Immunodeficiency 74, Covid-19-Related, X-Linked

Imd74

Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

Tlr7 Deficiency

X-Linked Immunodeficiency 74,Covid-19-Related

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Viral Infectious Disease

Arbovirus Infections

Viral Disease

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Anogenital Venereal Wart

Genital Warts

Condylomata Acuminata

Anogenital Warts

Condyloma Acuminatum

Anogenital Human Papilloma Virus Infectious Disease

Genital Wart Virus Infectious Disease

Venereal Wart

Venereal Warts

Verrucae Anogenitales

Verrucae Genitales

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TLR7 MGD MGI:2176882
Bos taurus TLR7 VGNC VGNC:52836
Rattus norvegicus TLR7 RGD RGD:1563357
Canis familiaris TLR7 VGNC VGNC:54607
Macaca mulatta TLR7 VGNC VGNC:78390