2. Immunology/Inflammation Apoptosis Anti-infection
  3. Toll-like Receptor (TLR) Apoptosis TNF Receptor HCV Interleukin Related
  4. PF-4878691

PF-4878691  (Synonyms: 3M-852A)

目录号: HY-100176 纯度: 99.64%
COA 产品使用指南 技术支持

PF-4878691 (3M-852A) 是一种有口服活性的 TLR7 激动剂。PF-4878691 具有固有免疫应答活性，对 HCV 具有抗病毒作用，可用于肿瘤的研究。

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PF-4878691 Chemical Structure

PF-4878691 Chemical Structure

CAS No. : 532959-63-0

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规格 价格 是否有货 数量
1 mg ￥950
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5 mg ￥2450
In-stock
10 mg ￥3900
In-stock
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Customer Review

PF-4878691 相关抗体

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].

IC50 & Target

TLR7

 

IL-6

 

IL-8

 

IL-1β

 

IL-2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
2657 nM
Compound: 852A
Agonist activity at human TLR7 expressed in HEK293 cells by NFkappaB SEAP reporter gene assay
Agonist activity at human TLR7 expressed in HEK293 cells by NFkappaB SEAP reporter gene assay
[PMID: 23265901]
体外研究
(In Vitro)

PF-4878691 (10 μM, 4 h) 诱导复杂的转录网络，负责激活浆细胞样树突状细胞的固有抗病毒免疫应答，优化对 RNA 病毒的应答，增加共刺激能力，并增加浆细胞样树突状细胞的存活率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PF-4878691 相关抗体:
体内研究
(In Vivo)

PF-4878691 (10-150 mg, Oral gavage, single dose) 诱导 BALB/c 小鼠和 C57bl/6 j 小鼠的药理学作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice , C57bl/6 J mice[3]
Dosage: 30 mg/kg, 60 mg/kg, 90 mg/kg, 150 mg/kg
Administration: Oral gavage (p.o.)
Result: Induced dose and time dependant lymphopenia and 2,5,oligoadenylate synthetase (2,5,OAS).
Caused cardiovascular changes.
Significantly increased TLR7 receptor RNA.
分子量

361.46

Formula

C17H23N5O2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料

纯度: 99.89%

COA (197 KB) HNMR (158 KB) LCMS (345 KB)

产品使用指南 (1538 KB)
参考文献

PF-4878691 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-4878691532959-63-03M-852APF4878691PF 4878691Toll-like Receptor (TLR)ApoptosisTNF ReceptorHCVInterleukin RelatedTumor Necrosis Factor ReceptorTNFRHepatitis C virusILplasmacytoid dendritic cellsagonisthealthy subjectscancerantiviralInhibitorinhibitorinhibit

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