2. Immunology/Inflammation Apoptosis Anti-infection
  3. Toll-like Receptor (TLR) Apoptosis TNF Receptor HCV Interleukin Related
  4. PF-4878691

PF-4878691  (Synonyms: 3M-852A)

目录号: HY-100176 纯度: 99.64%
COA 产品使用指南

摩尔计算器

PF-4878691 (3M-852A) 是一种有口服活性的 TLR7 激动剂。PF-4878691 具有固有免疫应答活性，对 HCV 具有抗病毒作用，可用于肿瘤的研究。

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PF-4878691 Chemical Structure

PF-4878691 Chemical Structure

CAS No. : 532959-63-0

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规格 价格 是否有货 数量
1 mg ￥950
In-stock
5 mg ￥2450
In-stock
10 mg ￥3900
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

PF-4878691 相关抗体

Top Publications Citing Use of Products

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].

IC50 & Target

TLR7

 

IL-6

 

IL-8

 

IL-1β

 

IL-2

 

体外研究
(In Vitro)

PF-4878691 (10 μM, 4 h) 诱导复杂的转录网络，负责激活浆细胞样树突状细胞的固有抗病毒免疫应答，优化对 RNA 病毒的应答，增加共刺激能力，并增加浆细胞样树突状细胞的存活率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PF-4878691 相关抗体:
体内研究
(In Vivo)

PF-4878691 (10-150 mg, Oral gavage, single dose) 诱导 BALB/c 小鼠和 C57bl/6 j 小鼠的药理学作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice , C57bl/6 J mice[3]
Dosage: 30 mg/kg, 60 mg/kg, 90 mg/kg, 150 mg/kg
Administration: Oral gavage (p.o.)
Result: Induced dose and time dependant lymphopenia and 2,5,oligoadenylate synthetase (2,5,OAS).
Caused cardiovascular changes.
Significantly increased TLR7 receptor RNA.
分子量

361.46

Formula

C17H23N5O2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料

纯度: 99.89%

COA (197 KB) HNMR (158 KB) LCMS (345 KB)

产品使用指南 (1538 KB)
参考文献

PF-4878691 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-4878691532959-63-03M-852APF4878691PF 4878691Toll-like Receptor (TLR)ApoptosisTNF ReceptorHCVInterleukin RelatedTumor Necrosis Factor ReceptorTNFRHepatitis C virusILplasmacytoid dendritic cellsagonisthealthy subjectscancerantiviralInhibitorinhibitorinhibit

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