NUDT2 - nudix hydrolase 2 Gene

中文名称：nudix 水解酶 2

种属: Homo sapiens

同用名: APAH1; IDDPN

关于 NUDT2

功能概要

该基因编码核苷酸焦磷酸酶 MutT 家族的一个成员，该家族是更大的 NUDIX 水解酶家族的一个子集。该基因产物具有在某些核苷酸焦磷酸酶中发现的 MutT 序列基序的修饰。该酶不对称水解 Ap4A 以产生 AMP 和 ATP，并负责维持二核苷酸 Ap4A 的细胞内水平，其功能尚未确定。该基因可能是一个候选的抑癌基因。已在该位点观察到选择性剪接，并已鉴定出全部编码相同蛋白质的四种转录物变体。[RefSeq 提供，2011 年 9 月]

This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The Enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]