APLP1 - amyloid beta precursor like protein 1 Gene

中文名称：淀粉样蛋白前体样蛋白 1

种属: Homo sapiens

同用名: APLP

关于 APLP1

功能概要

该基因编码高度保守的淀粉样蛋白前体蛋白基因家族的成员。编码的蛋白质是一种膜相关糖蛋白，它被分泌酶以类似于淀粉样蛋白 β A4 前体蛋白裂解的方式裂解。这种裂解释放出可作为转录激活因子的细胞内细胞质片段。编码的蛋白质也可能在皮质发育过程中的突触成熟中发挥作用。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]