2. Gene
  3. ARL16 - ADP ribosylation factor like GTPase 16 Gene

ARL16 - ADP ribosylation factor like GTPase 16 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ADP 核糖基化因子样 GTPase 16

种属: Homo sapiens

基因 ID: 339231 | 基因类型: protein coding

关于 ARL16

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,681,165-81,683,797 (from NCBI)

This gene has 13 transcripts (splice variants), 147 orthologues and 30 paralogues. Ubiquitous expression in kidney (RPKM 11.1), thyroid (RPKM 10.4) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 ARL (ADP-核糖基化因子样) 蛋白质家族，在结构上与 ADP-核糖基化因子 (ARF) 相关。这种蛋白质已被证明在细胞抗病毒反应中具有抑制作用。该基因产物与 DEXD/H-box 解旋酶 58 (DDX58) 基因产物的 C 末端结构域相互作用。发现这种相互作用会抑制 DDX58 基因产物与 RNA 之间的关联，从而负向调节 DDX58 基因产物的活性。[RefSeq 提供，2016 年 7 月]

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular Antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product. [provided by RefSeq, Jul 2016]

ARL16 基因产物(3)

mRNA Protein Name
NM_001040025.3 NP_001035114.2 ADP-ribosylation factor-like protein 16 isoform 1
NM_001329608.2 NP_001316537.1 ADP-ribosylation factor-like protein 16 isoform 2
NM_001329609.2 NP_001316538.1 ADP-ribosylation factor-like protein 16 isoform 3
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21233210 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
21233210 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARL16 蛋白结构

Arf

Arf: ADP-ribosylation factor family (21 - 191)

  • 0
  • 100
  • 197 a.a.
蛋白主名 其他名称

ADP-ribosylation factor-like protein 16

ARL16 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ARL16 Q0P5N6 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra ARL16 Q0P5N6 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra ARL16 Q0P5N6 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra ARL16 Q0P5N6 GLYR1 Homo sapiens Q49A26-4
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 GLYR1 Homo sapiens Q49A26-4
Validated Y2H
32296183
Intra ARL16 Q0P5N6 GLYR1 Homo sapiens Q49A26-4
Y2H Array
32296183
Intra ARL16 Q0P5N6 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra ARL16 Q0P5N6 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 APP Homo sapiens P05067-2
Y2H Pooling
32814053
Intra ARL16 Q0P5N6 APP Homo sapiens P05067-2
Validated Y2H
32814053
Intra ARL16 Q0P5N6 APP Homo sapiens P05067-2
Y2H Array
32814053
Intra ARL16 Q0P5N6 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra ARL16 Q0P5N6 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra ARL16 Q0P5N6 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra ARL16 Q0P5N6 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra ARL16 Q0P5N6 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra ARL16 Q0P5N6 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra ARL16 Q0P5N6 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra ARL16 Q0P5N6 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra ARL16 Q0P5N6 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra ARL16 Q0P5N6 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra ARL16 Q0P5N6 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra ARL16 Q0P5N6 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra ARL16 Q0P5N6 AMPH Homo sapiens P49418
Y2H Array
31515488
Intra ARL16 Q0P5N6 AMPH Homo sapiens P49418
Y2H Prey Pooling
25416956
Intra ARL16 Q0P5N6 AMPH Homo sapiens P49418
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 AMPH Homo sapiens P49418
Y2H Array
32296183
Intra ARL16 Q0P5N6 PDE6D Homo sapiens O43924
Y2H Prey Pooling
25416956
Intra ARL16 Q0P5N6 PDE6D Homo sapiens O43924
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 PDE6D Homo sapiens O43924
Y2H Array
25416956
Intra ARL16 Q0P5N6 PDE6D Homo sapiens O43924
Y2H Array
32296183
Intra ARL16 Q0P5N6 PDE6D Homo sapiens O43924
MAPPIT
32296183
Intra ARL16 Q0P5N6 DEUP1 Homo sapiens Q05D60
Y2H Array
32296183
Intra ARL16 Q0P5N6 DEUP1 Homo sapiens Q05D60
Y2H Prey Pooling
32296183
Intra ARL16 Q0P5N6 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra ARL16 Q0P5N6 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra ARL16 Q0P5N6 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood
Accommodative Esotropia

Esotropia With Accommodative Compensation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00984 ARL16 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ARL16 VGNC VGNC:99118
Bos taurus ARL16 VGNC VGNC:26141
Mus musculus ARL16 MGD MGI:1917567
Rattus norvegicus ARL16 RGD RGD:1590059
Felis catus ARL16 VGNC VGNC:59924
Canis familiaris ARL16 VGNC VGNC:38109
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