1. Gene
  2. ID1 - inhibitor of DNA binding 1 Gene

ID1 - inhibitor of DNA binding 1 Gene

中文名称:DNA 结合抑制因子 1

种属: Homo sapiens

同用名: ID; bHLHb24

基因 ID: 3397 | 基因类型: protein coding

关于 ID1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,605,289-31,606,510 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in lung (RPKM 56.6), colon (RPKM 54.0) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种螺旋-环-螺旋 (HLH) 蛋白质,可与基本 HLH 转录因子家族的成员形成异二聚体。编码的蛋白没有 DNA 结合活性,因此可以抑制与之相互作用的碱性 HLH 蛋白的 DNA 结合和转录激活能力。这种蛋白质可能在细胞生长、衰老和分化中发挥作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ID1 基因产物(2)

mRNA Protein Name
NM_002165.4 NP_002156.2 DNA-binding protein inhibitor ID-1 isoform a
NM_181353.3 NP_851998.1 DNA-binding protein inhibitor ID-1 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15694377 GOA
enables transcription regulator inhibitor activity IDA
IDA: 通过直接分析推断
7665172 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
7665172 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15138269 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7665172 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ID1 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (68 - 106)

  • 0
  • 100
  • 155 a.a.
蛋白主名 其他名称

DNA-binding protein inhibitor ID-1

class B basic helix-loop-helix protein 24

ID1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ID1 P41134 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
种属内
ID1 P41134 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
种属内
ID1 P41134 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
种属内
ID1 P41134 TCF3 Homo sapiens P15923-3
Y2H Array
32296183
种属内
ID1 P41134 TCF3 Homo sapiens P15923-3
Y2H Prey Pooling
32296183
种属内
ID1 P41134 ASCL3 Homo sapiens Q9NQ33
Y2H Prey Pooling
32296183
种属内
ID1 P41134 ASCL3 Homo sapiens Q9NQ33
Validated Y2H
32296183
种属内
ID1 P41134 ASCL3 Homo sapiens Q9NQ33
Y2H Array
32296183
种属内
ID1 P41134 CASK Homo sapiens O14936
Anti Bait CoIP
15694377
种属内
ID1 P41134 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
种属内
ID1 P41134 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
种属内
ID1 P41134 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
种属内
ID1 P41134 MYF5 Homo sapiens P13349
Y2H Array
32296183
种属内
ID1 P41134 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
种属内
ID1 P41134 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
种属内
ID1 P41134 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
种属内
ID1 P41134 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
ID1 P41134 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
ID1 P41134 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
ID1 P41134 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属内
ID1 P41134 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
ID1 P41134 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
ID1 P41134 MYOG Homo sapiens P15173
Y2H Array
32296183
种属内
ID1 P41134 MYOG Homo sapiens P15173
Y2H Prey Pooling
32296183
种属内
ID1 P41134 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
ID1 P41134 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
ID1 P41134 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
ID1 P41134 CAV1 Homo sapiens Q03135
Y2H
17855368
种属内
ID1 P41134 CAV1 Homo sapiens Q03135
Anti Bait CoIP
17855368
种属内
ID1 P41134 CAV1 Homo sapiens Q03135
IF
17855368
种属内
ID1 P41134 TCF12 Homo sapiens Q99081
Y2H Array
20211142
种属内
ID1 P41134 TCF12 Homo sapiens Q99081
Anti Tag CoIP
26496610
种属间: 跨种属相互作用 种属内: 同种属相互作用

ID1 抗体

目录号 产品名 应用 反应物种
HY-P83100 ID1 Antibody (YA2845) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Mouth Disease

Mouth Diseases

Mouth Disorders

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hemangioma

Hemangiomas

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva

Progressive Myositis Ossificans

FOP

Progressive Ossifying Myositis

Myositis Ossificans

Stone Man Syndrome

Man Of Stone

Myositis Ossificans Progressive

Diffuse Progressive Ossifying Polymyositis

Fibrodysplasia Ossificans Congenita

Myositis Ossificans Progressiva, Site Unspecified

Münchmeyer Disease

Fop - [Fibrodysplasia Ossificans Progressiva]

Progressive Myositis Ossificans Calcification

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease

Hht

Osler-Weber-Rendu Disease

Telangiectasia, Hereditary Hemorrhagic

Osler Hemorrhagic Telangiectasia Syndrome

Orw Disease

Osler Weber Rendu Syndrome

Osler-Rendu-Weber Disease

Osler-Weber-Rendu Syndrome

Rendu-Osler Disease

Telangiectasia Hereditary Hemorrhagic

Telangiectasia Hemorrhagic, Hereditary

Hht - [Hereditary Haemorrhagic Telangiectasia]

Osler Haemorrhagic Telangiectasia Syndrome

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ID1 VGNC VGNC:73556
Mus musculus ID1 MGD MGI:96396
Rattus norvegicus ID1 RGD RGD:2858
Bos taurus ID1 VGNC VGNC:30031
Felis catus ID1 VGNC VGNC:67692
Others ID1 NCBI