ID1 - inhibitor of DNA binding 1 Gene

中文名称：DNA 结合抑制因子 1

种属: Homo sapiens

同用名: ID; bHLHb24

基因 ID: 3397 | 基因类型: protein coding

关于 ID1

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,605,289-31,606,510 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in lung (RPKM 56.6), colon (RPKM 54.0) and 24 other tissues.

功能概要

该基因编码的蛋白质是一种螺旋-环-螺旋 (HLH) 蛋白质，可与基本 HLH 转录因子家族的成员形成异二聚体。编码的蛋白没有 DNA 结合活性，因此可以抑制与之相互作用的碱性 HLH 蛋白的 DNA 结合和转录激活能力。这种蛋白质可能在细胞生长、衰老和分化中发挥作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ID1 基因产物(2)

mRNA	Protein	Name
NM_002165.4	NP_002156.2	DNA-binding protein inhibitor ID-1 isoform a
NM_181353.3	NP_851998.1	DNA-binding protein inhibitor ID-1 isoform b

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15694377	GOA
enables transcription regulator inhibitor activity	IDA IDA: 通过直接分析推断	7665172	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	7665172	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	15138269	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	7665172	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ID1 蛋白结构

HLH

0
100
155 a.a.

蛋白主名

其他名称

DNA-binding protein inhibitor ID-1

class B basic helix-loop-helix protein 24

ID1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	ID1	P41134	TCF3	Homo sapiens	P15923-3	Y2H Array	32296183
Intra	ID1	P41134	TCF3	Homo sapiens	P15923-3	Y2H Prey Pooling	32296183
Intra	ID1	P41134	ASCL3	Homo sapiens	Q9NQ33	Y2H Prey Pooling	32296183
Intra	ID1	P41134	ASCL3	Homo sapiens	Q9NQ33	Validated Y2H	32296183
Intra	ID1	P41134	ASCL3	Homo sapiens	Q9NQ33	Y2H Array	32296183
Intra	ID1	P41134	CASK	Homo sapiens	O14936	Anti Bait CoIP	15694377
Intra	ID1	P41134	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	ID1	P41134	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	ID1	P41134	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	ID1	P41134	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	ID1	P41134	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	ID1	P41134	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	ID1	P41134	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	ID1	P41134	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	ID1	P41134	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	ID1	P41134	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	ID1	P41134	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	ID1	P41134	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	ID1	P41134	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	ID1	P41134	MYOG	Homo sapiens	P15173	Y2H Array	32296183
Intra	ID1	P41134	MYOG	Homo sapiens	P15173	Y2H Prey Pooling	32296183
Intra	ID1	P41134	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ID1	P41134	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ID1	P41134	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ID1	P41134	CAV1	Homo sapiens	Q03135	Y2H	17855368
Intra	ID1	P41134	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	17855368
Intra	ID1	P41134	CAV1	Homo sapiens	Q03135	IF	17855368
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081	Y2H Array	20211142
Intra	ID1	P41134	TCF12	Homo sapiens	Q99081	Anti Tag CoIP	26496610

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mouth Disease

Mouth Diseases

Mouth Disorders

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Hemangioma

Hemangiomas

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva	Progressive Myositis Ossificans
FOP	Progressive Ossifying Myositis
Myositis Ossificans	Stone Man Syndrome
Man Of Stone	Myositis Ossificans Progressive
Diffuse Progressive Ossifying Polymyositis	Fibrodysplasia Ossificans Congenita
Myositis Ossificans Progressiva, Site Unspecified	Münchmeyer Disease
Fop - [Fibrodysplasia Ossificans Progressiva]	Progressive Myositis Ossificans Calcification

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Hereditary Hemorrhagic Telangiectasia

Rendu-Osler-Weber Disease	Hht
Osler-Weber-Rendu Disease	Telangiectasia, Hereditary Hemorrhagic
Osler Hemorrhagic Telangiectasia Syndrome	Orw Disease
Osler Weber Rendu Syndrome	Osler-Rendu-Weber Disease
Osler-Weber-Rendu Syndrome	Rendu-Osler Disease
Telangiectasia Hereditary Hemorrhagic	Telangiectasia Hemorrhagic, Hereditary
Hht - [Hereditary Haemorrhagic Telangiectasia]	Osler Haemorrhagic Telangiectasia Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-124697	BMP signaling agonist sb4	Agonist	99.98%	否
HY-129241	AGX51	Antagonist	99.33%	否
HY-80012	SJB3-019A	Inhibitor	99.68%	否
HY-110245	DMH2	Inducer	99.6%	否
HY-RS06522	ID1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ID1	VGNC	VGNC:73556
Mus musculus	ID1	MGD	MGI:96396
Rattus norvegicus	ID1	RGD	RGD:2858
Bos taurus	ID1	VGNC	VGNC:30031
Felis catus	ID1	VGNC	VGNC:67692
Others	ID1	NCBI

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