1. Gene
  2. SH3RF3 - SH3 domain containing ring finger 3 Gene

SH3RF3 - SH3 domain containing ring finger 3 Gene

中文名称:含 SH3 结构域的无名指 3

种属: Homo sapiens

同用名: POSH2; SH3MD4

基因 ID: 344558 | 基因类型: protein coding

关于 SH3RF3

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:109,129,205-109,504,634 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 1.9), gall bladder (RPKM 1.8) and 25 other tissues.

功能概要

启用泛素蛋白连接酶活性。参与 JNK 级联和蛋白质自身泛素化的正调控。 [由基因组资源联盟提供,2022 年 4 月]

Enables ubiquitin protein Ligase activity. Involved in positive regulation of JNK cascade and protein autoubiquitination. [provided by Alliance of Genome Resources, Apr 2022]

SH3RF3 基因产物(1)

mRNA Protein Name
NM_001099289.3 NP_001092759.1 E3 ubiquitin-protein ligase SH3RF3 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16374509 GOA
enables ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
20696164 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
20696164 GOA
involved in protein autoubiquitination IMP
IMP: 通过突变表型推断
20696164 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SH3RF3 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (57 - 97)

SH3_9

SH3_9: Variant SH3 domain (201 - 249)

SH3_9

SH3_9: Variant SH3 domain (263 - 315)

SH3_9

SH3_9: Variant SH3 domain (471 - 521)

SH3_9

SH3_9: Variant SH3 domain (831 - 880)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 882 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase SH3RF3

SH3 domain-containing RING finger protein 3

SH3RF3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SH3RF3 Q8TEJ3 PAK2 Homo sapiens Q13177
Phage Display
16374509
种属内
SH3RF3 Q8TEJ3 PAK2 Homo sapiens Q13177
Filter Binding
16374509
种属内
SH3RF3 Q8TEJ3 RAC1 Homo sapiens P63000
Solid Phase Assay
20696164
种属内
SH3RF3 Q8TEJ3 RAC1 Homo sapiens P63000
Anti Tag CoIP
20696164
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 17

RP17

Retinitis Pigmentosa-17

Retinitis Pigmentosa, Type 17

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SH3RF3 VGNC VGNC:46134
Macaca mulatta SH3RF3 VGNC VGNC:77302
Felis catus SH3RF3 VGNC VGNC:65115
Rattus norvegicus SH3RF3 RGD RGD:1589772
Bos taurus SH3RF3 VGNC VGNC:34581
Mus musculus SH3RF3 MGD MGI:2444637
Others SH3RF3 NCBI