2. Gene
  3. Ehmt2 - euchromatic histone lysine methyltransferase 2 Gene

Ehmt2 - euchromatic histone lysine methyltransferase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：常染色体组蛋白赖氨酸甲基转移酶 2

种属: Rattus norvegicus

同用名: G9a; Bat8; Ng36

基因 ID: 361798 | 基因类型: protein coding

关于 Ehmt2

Primary_assembly 20: 3,919,624-3,941,547 reverse strand.mRatBN7.2:CM026993.1

This gene has 3 transcripts (splice variants), 210 orthologues, 23 paralogues and is associated with 16 phenotypes. Biased expression in Adrenal (RPKM 211.8), Kidney (RPKM 174.5) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 C2H2 锌指结构域结合活性；组蛋白-赖氨酸 N-甲基转移酶活性；和 p53 结合活性。涉及多个过程，包括长期记忆；组蛋白甲基化的调节；和对杀菌剂的反应。位于核内。该基因的人类直系同源物与特发性肺纤维化有关。与人类 EHMT2（常染色质组蛋白赖氨酸甲基转移酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including C2H2 zinc finger domain binding activity; histone-lysine N-methyltransferase activity; and p53 binding activity. Involved in several processes, including long-term memory; regulation of histone methylation; and response to fungicide. Located in nucleus. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt2 基因产物(1)

mRNA Protein Name
NM_212463.1 NP_997628.1 histone-lysine N-methyltransferase EHMT2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
22880885 RGD
involved in long-term memory IMP
IMP: 通过突变表型推断
22514307 RGD
involved in regulation of protein modification process IMP
IMP: 通过突变表型推断
22514307 RGD
involved in response to alcohol IEP
IEP: 通过表达模式推断
26509893 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
23413810 RGD
involved in response to fungicide IEP
IEP: 通过表达模式推断
22496781 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
19001366 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
22880885 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ehmt2 蛋白结构

PHA03247

PHA03247: cl33720 (4 - 257)

EHMT_ZBD

EHMT_ZBD: cd20905 (472 - 601)

Ank_2

Ank_2: pfam12796 (716 - 803)

ANK

ANK: sd00045 (748 - 777)

Ank_2

Ank_2: pfam12796 (784 - 877)

ANK

ANK: sd00045 (812 - 844)

ANK

ANK: sd00045 (847 - 877)

Ank_2

Ank_2: pfam12796 (851 - 943)

ANK

ANK: sd00045 (879 - 910)

ANK

ANK: sd00045 (912 - 943)

SET_EHMT2

SET_EHMT2: cd10533 (1010 - 1248)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1273 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase EHMT2

HLA-B associated transcript 8, rat orthologue

euchromatic histone-lysine N-methyltransferase 2

histone-lysine N-methyltransferase, H3 lysine-9 specific 3

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16705 BRD4770 Inhibitor 99.69% 否
HY-111904 EHMT2-IN-2 Inhibitor ≥99.0% 否
HY-15647 BRD9539 Inhibitor 99.74% 否
HY-111778 EHMT2-IN-1 Inhibitor 99.85% 否
HY-161759 MS152 Inhibitor 99.36% 否
HY-133031 CSV0C018875 Inhibitor / 否
HY-133031A CSV0C018875 hydrochloride Inhibitor / 否
HY-44062 G9a-IN-1 Inhibitor 98.12% 否
HY-RS04230 EHMT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04231 Ehmt2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04232 Ehmt2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ehmt2 NCBI NCBI:10919
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