1. Gene
  2. ARF1 - ADP ribosylation factor 1 Gene

ARF1 - ADP ribosylation factor 1 Gene

中文名称:ADP 核糖基化因子 1

种属: Homo sapiens

同用名: PVNH8

基因 ID: 375 | 基因类型: protein coding

关于 ARF1

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,082,708-228,099,212 (from NCBI)

This gene has 12 transcripts (splice variants), 219 orthologues, 30 paralogues and is associated with 3 phenotypes. Ubiquitous expression in placenta (RPKM 152.3), thyroid (RPKM 137.5) and 25 other tissues.

功能概要

ADP-核糖基化因子 1 (ARF1) 是人类 ARF 基因家族的成员。该家族成员编码小的鸟嘌呤核苷酸结合蛋白,可刺激霍乱毒素的 ADP-核糖基转移酶活性,并作为磷脂酶 D 的激活剂在囊泡运输中发挥作用。该基因产物包括 6 种 ARF 蛋白和 11 种 ARF 样蛋白,构成 Ras 超家族的家族。 ARF 蛋白分为 I 类 (ARF1、ARF2 和 ARF3) 、II 类 (ARF4 和 ARF5) 和 III 类 (ARF6) ,每一类的成员共享一个共同的基因组织。 ARF1 蛋白定位于高尔基体,在高尔基体内部运输中起着核心作用。已为该基因发现了编码相同蛋白质的多个可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of Phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the Ras superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ARF1 基因产物(4)

mRNA Protein Name
NM_001024226.2 NP_001019397.1 ADP-ribosylation factor 1
NM_001024227.1 NP_001019398.1 ADP-ribosylation factor 1
NM_001024228.2 NP_001019399.1 ADP-ribosylation factor 1
NM_001658.4 NP_001649.1 ADP-ribosylation factor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10198630 GOA
enables protein domain specific binding IMP
IMP: 通过突变表型推断
12668765 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to virus IMP
IMP: 通过突变表型推断
28389568 GOA
involved in intracellular copper ion homeostasis IMP
IMP: 通过突变表型推断
21034850 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell leading edge IDA
IDA: 通过直接分析推断
22573891 GOA
part of protein-containing complex IMP
IMP: 通过突变表型推断
12668765 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ARF1 蛋白结构

Arf

Arf: ADP-ribosylation factor family (7 - 176)

  • 0
  • 100
  • 181 a.a.
蛋白主名 其他名称

ADP-ribosylation factor 1

ARF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARF1 P84077 SPAG9 Homo sapiens O60271
SPR
19644450
种属内
ARF1 P84077 IQGAP1 Homo sapiens P46940 36396045
种属内
ARF1 P84077 CYTH2 Homo sapiens Q99418 17563369
种属内
ARF1 P84077 CYTH2 Homo sapiens Q99418 14654833
种属内
ARF1 P84077 ARFIP2 Homo sapiens P53365
SLC
31467278
种属内
ARF1 P84077 ARFIP2 Homo sapiens P53365 35271311
种属内
ARF1 P84077 ARFIP2 Homo sapiens P53365 31467278
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ARF1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72089 ARF1 Protein, Human (His-GST, Myc) P84077 (G2-K181) ≥95%

关联疾病

疾病名称 别名
Periventricular Nodular Heterotopia 8

PVNH8

Periventricular Nodular Heterotopia

Periventricular Heterotopia

Pvnh

Familial Nodular Heterotopia

Heterotopia, Periventricular

Periventricular Heterotopia, X-Linked

Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera

Legionnaire Disease

Legionnaires' Disease

Legionnaires Disease

Legionnaire Disease, Susceptibility To

Legionella

Legionella Pneumonia

Infection By Legionella Pneumophilia

Legionnaire'S Disease

Legionellosis

Legionaire Disease, Susceptibility To

Legionnaires Pneumonia

Nonparalytic Poliomyelitis

Acute Nonparalytic Poliomyelitis

Non-Paralytic Aseptic Meningitis

Legionellosis

Legionella Infection

Pontiac Fever

Legionnaires' Disease

Infection By Legionella Pneumophilia

Legionella Pneumophila Infection

Tangier Disease

Analphalipoproteinemia

High Density Lipoprotein Deficiency, Tangier Type

TGD

High Density Lipoprotein Deficiency, Type 1

Hdldt1

Familial High Density Lipoprotein Deficiency

A-Alphalipoprotein Neuropathy

Alpha High Density Lipoprotein Deficiency Disease

Cholesterol Thesaurismosis

Familial High Density Lipoprotein Deficiency Disease

Hdl Lipoprotein Deficiency Disease

Tangier Disease Neuropathy

Familial Alpha-Lipoprotein Deficiency

Familial High-Density Lipoprotein Deficiency 1

Primary Hypoalphalipoproteinemia 1

Analphalipo-Proteinemia

Familial Hypoalphalipo-Proteinemia

Familial Hypoalphalipoproteinemia

Lipoprotein Deficiency Disease, Hdl, Familial

Tangier Hereditary Neuropathy

Atp-Binding Cassette Transporter A1 Deficiency

Hdld1

High Density Lipoprotein Deficiency 1

Tangier Disease, Variant

Hypoalphalipoproteinemia, Familial

Familial Hdl Deficiency

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ARF1 MGD MGI:99431
Felis catus ARF1 VGNC VGNC:102161
Rattus norvegicus ARF1 RGD RGD:621270
Bos taurus ARF1 VGNC VGNC:50209
Others ARF1 NCBI
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