KCNK1 - potassium two pore domain channel subfamily K member 1 Gene

中文名称：钾二孔域通道亚家族 K 成员 1

种属: Homo sapiens

同用名: DPK; HOHO; K2P1; KCNO1; TWIK1; K2p1.1; TWIK-1

基因 ID: 3775 | 基因类型: protein coding

关于 KCNK1

Cytogenetic location: 1q42.2 Genomic coordinates (GRCh38): 1:233,614,106-233,672,514 (from NCBI)

This gene has 6 transcripts (splice variants), 234 orthologues and 14 paralogues. Broad expression in brain (RPKM 19.7), stomach (RPKM 14.9) and 18 other tissues.

功能概要

该基因编码含有两个成孔 P 结构域的钾通道蛋白超家族成员之一。该基因的产物尚未显示为功能通道，但是，它可能需要其他非成孔蛋白才能发挥作用。[RefSeq 提供，2008 年 7 月]

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require Other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]

KCNK1 基因产物(1)

mRNA	Protein	Name
NM_002245.4	NP_002236.1	potassium channel subfamily K member 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	20498050	GOA
enables potassium channel activity	IDA IDA: 通过直接分析推断	22282804	GOA
enables potassium ion leak channel activity	IDA IDA: 通过直接分析推断	21653227	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	20498050	GOA
enables sodium channel activity	IDA IDA: 通过直接分析推断	21653227	GOA
NOT enables voltage-gated potassium channel activity	IDA IDA: 通过直接分析推断	21653227	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in potassium ion transmembrane transport	IDA IDA: 通过直接分析推断	21653227	GOA
involved in regulation of resting membrane potential	IMP IMP: 通过突变表型推断	21653227	GOA
involved in sodium ion transmembrane transport	IDA IDA: 通过直接分析推断	21653227	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	22282804	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	21653227	GOA
part of potassium channel complex	IDA IDA: 通过直接分析推断	22282804	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNK1 蛋白结构

Ion_trans_2

0
100
200
300
336 a.a.

蛋白主名

其他名称

potassium channel subfamily K member 1

inward rectifying potassium channel protein TWIK-1

KCNK1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	KCNK1	O00180	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
种属内	KCNK1	O00180	STOM	Homo sapiens	P27105	Validated Y2H	32296183
种属内	KCNK1	O00180	STOM	Homo sapiens	P27105	Y2H Array	32296183
种属内	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
种属内	KCNK1	O00180	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	KCNK1	O00180	CDIPT	Homo sapiens	O14735	Y2H Array	32296183
种属内	KCNK1	O00180	CDIPT	Homo sapiens	O14735	Validated Y2H	32296183
种属内	KCNK1	O00180	KCNK1	Homo sapiens	O00180	FRET	20498050
种属内	KCNK1	O00180	386682	Homo sapiens	EBI-10171679	Validated Y2H	25416956
种属内	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
种属内	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
种属内	KCNK1	O00180	386682	Homo sapiens	EBI-10171679	Y2H Array	25416956
种属内	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
种属内	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
种属内	KCNK1	O00180	KCNK1	Homo sapiens	O00180	X-Ray Diffraction	22282804
种属内	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
种属内	KCNK1	O00180	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
种属内	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
种属内	KCNK1	O00180	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
种属内	KCNK1	O00180	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
种属内	KCNK1	O00180	SUMO1	Homo sapiens	P63165	Pull Down	20498050
种属内	KCNK1	O00180	SUMO1	Homo sapiens	P63165	FRET	20498050
种属内	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
种属内	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
种属内	KCNK1	O00180	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Myasthenic Syndrome, Congenital, 8

Congenital Myasthenic Syndrome 8	CMS8
Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects	Cmsppd
Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects	Congenital Myasthenic Syndrome Due To Agrin Deficiency
Myasthenic Syndrome, Congenital, Due To Agrin Deficiency	Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects
Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects

Hypokalemia

Potassium Deficiency	Potassium Deficiency Disorder
Hypopotassemia	Potassium
Potassium [K] Deficiency	Hypokalaemic Syndrome
Hypopotassaemia	Hypopotassaemia Syndrome
Hypokalaemic	Potassium Depletion

Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome	BIBARS
Mental Retardation With Hypotonia And Facial Dysmorphism	Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome
Kcnk9 Imprinting Syndrome

Myasthenic Syndrome, Congenital, 10

Congenital Myasthenic Syndrome 10	CMS10
Lgm	Myasthenia, Limb-Girdle, Familial
Myasthenia, Limb-Girdle, Familial, Formerly	Lgm, Formerly
Congenital Myasthenic Syndrome Type Ib, Formerly	Cms1b, Formerly
Cms Ib, Formerly	Myasthenic Myopathy, Formerly
Familial Limb-Girdle Myasthenia	Cms1b
Cms Ib	Congenital Myasthenic Syndrome Type 1b
Congenital Myasthenic Syndrome Type Ib	Myasthenic Myopathy
Myasthenic Syndrome, Congenital, Type 10	Congenital Myasthenic Syndrome Ib
Myopathy In Myasthenia Gravis

Progressive Familial Heart Block

Hereditary Bundle Branch Defect	Hereditary Bundle Branch System Defect
Familial Lenegre Disease	Familial Lev Disease
Familial Lev-Lenegre Disease	Familial Pccd
Familial Progressive Heart Block	Pfhb
Bundle Branch Block	Hbbd
Lenegre Lev Disease	Lev Syndrome
Lev'S Disease	Lev-Lenègre Disease
Pccd	Progressive Cardiac Conduction Defect
Bundle-Branch Block

Brain Glioblastoma Multiforme

Brain Glioblastoma	Glioblastoma Multiforme Of Brain
Glioblastoma Nos

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07152	KCNK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	KCNK1	MGD	MGI:109322
Bos taurus	KCNK1	VGNC	VGNC:30465
Rattus norvegicus	KCNK1	RGD	RGD:621447
Macaca mulatta	KCNK1	VGNC	VGNC:73993
Canis familiaris	KCNK1	VGNC	VGNC:51902

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KCNK1 - potassium two pore domain channel subfamily K member 1 Gene

关于 KCNK1

功能概要

KCNK1 基因产物(1)

KCNK1 蛋白结构

KCNK1 蛋白互作信息

关联疾病

直系同源

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KCNK1 - potassium two pore domain channel subfamily K member 1 Gene

关于 KCNK1

功能概要

KCNK1 基因产物(1)

KCNK1 蛋白结构

KCNK1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

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