1. Gene
  2. KNG1 - kininogen 1 Gene

KNG1 - kininogen 1 Gene

中文名称:激肽原 1

种属: Homo sapiens

同用名: BK; HK; BDK; KNG; HAE6; HMWK

基因 ID: 3827 | 基因类型: protein coding

关于 KNG1

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,717,359-186,744,410 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward liver (RPKM 432.8).

功能概要

该基因使用选择性剪接产生两种不同的蛋白质——高分子量激肽原 (HMWK) 和低分子量激肽原 (LMWK) 。 HMWK 对于血液凝固和激肽释放酶-激肽系统的组装至关重要。此外,缓激肽是一种引起多种生理效应的肽,从 HMWK 中释放出来。缓激肽还用作具有抗菌和抗真菌活性的抗菌肽。与 HMWK 不同,LMWK 不参与血液凝固。感染严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 会减少或耗尽血管紧张素转换酶 2 (ACE2) ,从而导致 des-Arg (9) -缓激肽水平升高,这是缓激肽的一种生物活性代谢产物与肺损伤和炎症有关。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供,2020 年 9 月]

This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with Antibacterial and Antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting Enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]

KNG1 基因产物(3)

mRNA Protein Name
NM_000893.4 NP_000884.1 kininogen-1 isoform 2 precursor
NM_001102416.3 NP_001095886.1 kininogen-1 isoform 1 precursor
NM_001166451.2 NP_001159923.1 kininogen-1 isoform 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
3488317 GOA
enables hormone activity IDA
IDA: 通过直接分析推断
1314587 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8710908 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
11290596 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12074933 GOA
involved in killing of cells of another organism IDA
IDA: 通过直接分析推断
12074933 GOA
involved in negative regulation of blood coagulation IDA
IDA: 通过直接分析推断
11970955 GOA
involved in negative regulation of cell adhesion IDA
IDA: 通过直接分析推断
11970955 GOA
involved in negative regulation of proteolysis IDA
IDA: 通过直接分析推断
3488317 GOA
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
16014619 GOA
involved in vasodilation IDA
IDA: 通过直接分析推断
4322742 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
3488317 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KNG1 蛋白结构

Cystatin

Cystatin: Cystatin domain (24 - 114)

Cystatin

Cystatin: Cystatin domain (144 - 236)

Cystatin

Cystatin: Cystatin domain (266 - 360)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 644 a.a.
蛋白主名 其他名称

kininogen-1

alpha-2-thiol proteinase inhibitor

重组 KNG1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70956 Kininogen-1 Protein, Human (409a.a, HEK293, His) P01042-2 (Q19-S427) ≥95%
HY-P73266 Kininogen-1 Protein, Human (626a.a, HEK293, His) NP_001095886.1 (Q19-S644) ≥95%

关联疾病

疾病名称 别名
Angioedema, Hereditary, 6

HAE6

Angioedema, Hereditary, Type 6

High Molecular Weight Kininogen Deficiency

HMWK DEFICIENCY

Fitzgerald Trait

Congenital High-Molecular-Weight Kininogen Deficiency

Flaujeac Factor Deficiency

Kininogen Deficiency, High Molecular Weight

Kininogen Deficiency

Hmwk

High-Molecular-Weight Kininogen Deficiency, Congenital

Hereditary Angioedema With Normal C1inh Not Related To F12 Or Plg Variant
Angioedema

Angioneurotic Oedema

Quincke'S Edema

Angioneurotic Edema

Giant Urticaria

Brain Edema

Cerebral Edema

Intracranial Swelling

Wet Brain

Hereditary Angioedema

Hereditary Angioneurotic Edema

Hereditary Angioedema Type 1

Hane

Angioedema, Hereditary

Hae

Angioedemas, Hereditary

Deficiency Of C1 Esterase Inhibitor

C1 Esterase Inhibitor Deficiency

C1 Inhibitor Deficiency

Familial Angioneurotic Edema

Hereditary Bradykinine-Induced Angioedema

Hereditary Non Histamine-Induced Angioedema

Hae 1

Hae-I

Hereditary Angioneurotic Edema Type 1

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Hereditary Angioneurotic Oedema

Familial Angioedema

Hae - [Hereditary Angioneurotic Oedema]

Bannister Disease, Hereditary

Quincke Disease Or Oedema

Hereditary Quincke Oedema

Allergic Rhinitis

Hay Fever

Allergic Rhinitis, Susceptibility To

ALRH

Atopic Rhinitis

Seasonal Allergic Rhinitis

Non-Seasonal Allergic Rhinitis

Perenial Allergic Rhinitis

Pollenosis

Rhinitis Allergic Seasonal

Rhinitis, Allergic, Perennial

Allergic Rhinitis, Cause Unspecified

Pollinosis

Pollen Allergy

Allergy Nos Due To Pollen

Summer Catarrh

Other Seasonal Allergic Rhinitis

Impotence

Erectile Dysfunction

Sexual Impotence

Erectile Dysfunction Adverse Event

C1 Inhibitor Deficiency

Quincke Edema

Angioedemas, Hereditary

Angioedema

Acquired Angioedema

Acquired C1 Inhibitor Deficiency

Angioedema, Acquired

Aae

Acquired Angioneurotic Edema

Acquired Bradykinine-Induced Angioedema

Acquired Non Histamine-Induced Angioedema

Acquired Angioneurotic Oedema

Aae - [Acquired Angioneurotic Oedema]

Angina Pectoris

Prinzmetal'S Variant Angina

Angina

Prinzmetal Angina

Variant Angina

Angina Inversa

Prinzmetal'S Angina

Coronary Artery Vasospasm

Angina Pectoris, Variant

Variant Angina Pectoris

Vasospastic Angina

Angor Pectoris

Anginal Syndrome

Ischaemic Chest Pain

Angina Pectoris Syndrome

Angina Syndrome

Cardiac Angina Syndrome

Ap - [Angina Pectoris]

Angina Nos

Ap - [Angina Pectoris] Syndrome

Ischaemic Heart Disease With Angina

Heart Angina

Chest Angina

Angina Attack

Anginal Cardiopathy

Coronary Pain Nos

Rhinitis

Runny Nose

Congestive Heart Failure

Congestive Heart Disease

Heart Failure

Cardiac Failure Congestive

Chf

Weak Heart

Heart Failure Congestive

Ccf - [Congestive Cardiac Failure]

Chf - [Congestive Heart Failure]

Congestive Cardiac Diseases

Congested Heart Failure

Congestive Cardiac Failure

Cardiac Anasarca

Cardiac Oedema

Cardiac Stasis

Cardiovascular Oedema

Cardiac Hydrops

Congestive Failure

Heart Congestion

Heart Fluid

Oedematous Heart

Vascular Disease

Vascular Diseases

Aneurysm

Spinal Cord Ischemia

Vascular Anomaly

Spinal Cord Vascular Diseases

Vascular Tissue Disease

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Renal Hypertension

Hypertension Renal

Hypertension, Renal

Ischemia

Acute Coronary Syndrome

Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Retinitis Pigmentosa 87 With Choroidal Involvement

RP87

Retinitis Pigmentosa 87

Retinitis Pigmentosa, Type 87, Choroidal Involvement

Cystitis

Infective Cystitis

Urocystitis

Pyocystitis

Pulmonary Edema
Alveolar Periostitis

Dry Socket

Alveolitis Of Jaw

Dry Tooth Socket

Alveolar Pyorrhea

Alveolar Osteitis

Alveolitis Sicca Dolorosa

Alveolodental Periostitis

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Myofascial Pain Syndrome

Myofascial Pain Syndromes

Myofascial Pain Dysfunction Syndrome

Fibromyalgia

Whiplash
Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera

Cholinergic Urticaria
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Angioedema, Hereditary, 3

Angioedema, Hereditary, Type Iii

Hereditary Angioedema Type Iii

Hereditary Angioedema Type 3

HAE3

Estrogen-Related Hae

Estrogen-Sensitive Hae

Angioneurotic Edema, Hereditary, With Normal C1 Inhibitor Concentration And Function

Hae With Normal C1 Inhibitor Concentration And Function

Hereditary Angioedema With Normal C1 Inhibitor Activity

F12-Related Hereditary Angioedema With Normal C1inh

F12-Related Hae With Normal C1 Inhibitor

Hae 3

Hae-Iii

Hereditary Angioneurotic Edema Type 3

Inherited Estrogen-Associated Angioedema

Inherited Estrogen-Associated Angioneurotic Edema

Inherited Estrogen-Dependent Angioedema

Inherited Estrogen-Dependent Angioneurotic Edema

Angioneurotic Edema Hereditary With Normal C1 Inhibitor Concentration And Function

Hereditary Angioedema With Normal C1 Esterase Inhibitor Activity

Rocuronium Allergy

Esmeron Allergy

Zemuron Allergy

Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Properdin Deficiency, X-Linked

Properdin Deficiency

PFD

CFPD

Properdin P Factor Deficiency

Complement Factor Properdin Deficiency

X-Linked Properdin Deficiency

Properdin Deficiency, Type I

Properdin Deficiency, Type 1

Properdin Deficiency Disease

Renovascular Hypertension

Hypertension, Renovascular

Hypertension Renovascular

Allergic Disease

Hypersensitivity

Allergic Hypersensitivity Disease

Allergic Condition

Allergic Reaction

Allergic Disposition

Toxic Myocarditis
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Varicose Veins

Varices

Varix

Venous Ectasia

Venous Varices

Varicosity

Pyruvate Kinase Deficiency Of Red Cells

Pyruvate Kinase Deficiency

Pk Deficiency

Pyruvate Kinase Deficiency Of Erythrocyte

Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency

Pyruvate Kinase Deficiency Of Erythrocytes

Pkd

PKRD

Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency

Hnsha

Pyruvate Kinase-Deficient Hemolytic Anemia

Red Cell Pyruvate Kinase Deficiency

Deficiency Of Pyruvate Kinase

Anemia, Hemolytic, Congenital Nonspherocytic

Chronic Inducible Urticaria
Pulpitis

Pulp Stones

Pulpitis Nos

Complex Regional Pain Syndrome

Complex Regional Pain Syndromes

Reflex Sympathetic Dystrophy

Crps

Congenital Nonspherocytic Hemolytic Anemia

Hereditary Non-Spherocytic Hemolytic Anemia

Hereditary Nonspherocytic Hemolytic Anemia

Anemia, Hemolytic, Congenital Nonspherocytic

Congenital Nonspherocytic Hemolytic Anaemia

Hereditary Nonspherocytic Hemolytic Anaemia

Hnsha

Angioedema, Hereditary, 1

Hereditary Angioedema Type I

Hereditary Angioneurotic Edema

Hane

C1 Esterase Inhibitor Deficiency

Angioedema, Hereditary, 1 And 2

HAE1

Angioneurotic Edema, Hereditary

Angioedema, Hereditary, Type I

Hereditary Angioedema Type 2

Hae 2

Hae-Ii

Hereditary Angioneurotic Edema Type 2

Angioedema, Hereditary

HAE

Angioedema, Hereditary, Types I And Ii

Hereditary Angioedema, Type Ii

Angioedema, Hereditary, Type 1

Angioedemas, Hereditary

Hereditary C1 Esterase Inhibitor Deficiency - Dysfunctional Factor

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Factor Xii Deficiency

Hageman Factor Deficiency

Haf Deficiency

Factor Xii Deficiency Disease

F12 Deficiency

Deficiency, Hageman

Coagulation Factor 12 Deficiency

Factor 12 Deficiency

Congenital Factor Xii Deficiency

Congenital Hageman Factor Deficiency

FA12D

Factor Xii

Deficiency, Factor Xii

Physical Urticaria

Symptomatic Dermographism

Causalgia

Complex Regional Pain Syndrome, Type Ii

Complex Regional Pain Syndrome Type 2

Thiopental Allergy

Penthiobarbital Allergy

Pentothiobarbital Allergy

Dermatographia

Dermatographic Urticaria

Dermographism

Symptomatic Dermographism

Urticaria Factitia

Factitious Urticaria

Dermatographism

Zebrafish Allergy

Danio Rerio Allergy

Atherosclerosis Susceptibility

Atherosclerosis

Atherosclerosis, Susceptibility To

ATHS

Atherogenic Lipoprotein Phenotype

Alp

Arteriosclerosis

Myocardial Stunning
Coronary Artery Vasospasm

Coronary Vasospasm

Coronary Artery Spasm

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Acute Kidney Failure

Acute Renal Failure

Acute Kidney Injury

Renal Failure Acute

Kidney Failure, Acute

Pre-Renal Acute Kidney Injury

Nontraumatic Acute Kidney Injury

Aki - [Acute Kidney Injury]

Arf - [Acute Kidney Failure]

Acute Kidney Disease

Acute Kidney Impairment

Acute Ischaemic Renal Failure

Acute Hypoxic Kidney Failure

Acute Kidney Shutdown

Acute Renal Oedema

Acute Renal Impairment

Acute Kidney Collapse

Acute Necrotising Kidney

Acute Renal Suppression

Laryngeal Small Cell Carcinoma

Small Cell Carcinoma Of Larynx

Allergic Urticaria
Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To

Pain Agnosia

Analgesia

Complement Deficiency

Complement Deficiency Disease

Hereditary Complement Deficiency Diseases

Pleurisy
Epiglottitis

Acute Epiglottitis

Acute Epiglottitis And Supraglottitis

Acute Epiglottiditis

Epiglottiditis

Epiglottitis Nos

Vasomotor Rhinitis

Rhinitis, Vasomotor

Rhinitis Vasomotor

Vmr - [Vasomotor Rhinitis]

Malignant Secondary Hypertension
Pericoronitis

Operculitis

Agnosia

Dyspraxia

Primary Visual Agnosia

Dyspraxia Syndrome

Monomodal Visual Amnesia

Visual Amnesia

Agnosia, Primary Visual

Apraxias

Alexia

Trigeminal Nerve Disease

Trigeminal Nerve Diseases

Disorders Of 5th Cranial Nerve

Disorders Of The Fifth Cranial Nerve

Interstitial Cystitis

Bladder Pain Syndrome

Painful Bladder Syndrome

Ulcerative Cystitis

Ic/Bps

Ic/Pbs

Interstitial Cystitis/Bladder Pain Syndrome

Interstitial Cystitis/Painful Bladder Syndrome

Cystitis, Interstitial

Chronic Interstitial Cystitis

Pelvic Congestion Syndrome

Trigonitis

Bursitis

Bursitis, Not Otherwise Specified

Inflammation Of Bursa

Carotid Artery Occlusion

Occlusion And Stenosis Of Carotid Artery

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency

Rosenthal Syndrome

Pta Deficiency

Hemophilia C

Rosenthal Factor Deficiency

F11 Deficiency

Congenital Factor Xi Deficiency

Hereditary Factor Xi Deficiency Disease

Haemophilia C

Factor Xi Deficiency, Autosomal Dominant

Rosenthal'S Disease

Factor 11 Deficiency

Factor Xi

Factor Xi Deficiency, Autosomal Recessive

Factor Xi Deficiency, Congenital

FA11D

Thromboplastin Antecedent Deficiency

Pta - [Plasma Thromboplastin Antecedent] Deficiency

Congenital Factor Xi Deficiency Disease

Rosenthal Disease

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor

Psychosomatic Disorder

Psychophysiologic Disorders

Acute Salpingo-Oophoritis

Acute Salpingitis And Oophoritis

Occlusion Precerebral Artery

Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries

Occlusion And Stenosis Of Precerebral Artery

Uvulitis

Acute Uvulitis

Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction

Autonomic Nervous System Disorders

Autonomic Nervous System Disorder

Autonomic Nervous System Diseases

Abnormality Of The Autonomic Nervous System

Oxirane Allergy

Ethylene Oxide Allergy

Eto Allergy

Hypertrophy Of Tongue Papillae

Tongue Papillary Hypertrophy

Hypertrophy Of Foliate Papillae

Paine Syndrome

Pain Disorder

Pain

Microcephaly With Spastic Diplegia

Pain Syndrome

Retinitis Pigmentosa 46

RP46

Retinitis Pigmentosa, Autosomal Recessive, Idh3b-Related

Retinitis Pigmentosa Autosomal Recessive Idh3b-Related

Retinitis Pigmentosa, Type 46

Interval Angle-Closure Glaucoma

Intermittent Angle-Closure Glaucoma

Angle-Closure Glaucoma, Subacute

Prodromal Angle Closure Glaucoma

Integumentary System Disease
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Diabetes Mellitus

Diabetes

Ventricular Fibrillation, Paroxysmal Familial, 1

Paroxysmal Familial Ventricular Fibrillation

Ivf

Ventricular Fibrillation, Idiopathic

Ventricular Fibrillation

VF1

Vf

Ventricular Fibrillation, Familial, 1

Paroxysmal Ventricular Fibrillation

Idiopathic Ventricular Fibrillation

Ventricular Fibrillation, Paroxysmal Familial, Type 1

Ventricular Fibrillation, Paroxysmal Familial

Familial Paroxysmal Ventricular Fibrillation 1

Susceptibility To Ventricular Fibrillation During Myocardial Infarction

Ventricular Fibrillation Adverse Event

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Night Blindness, Congenital Stationary, Type 1h

Congenital Stationary Night Blindness 1h

CSNB1H

Congenital Stationary Night Blindness Type 1h

Night Blindness, Congenital Stationary, 1h

Combined Oxidative Phosphorylation Deficiency 33

COXPD33

Akinetopsia
Phenytoin Allergy

Dilantin Allergy

Endobronchial Lipoma
Respiratory Failure

Acute Respiratory Failure

Chronic Respiratory Failure

Respiratory Insufficiency

Acute-On-Chronic Respiratory Failure

Respiratory Disease

Acute And Chronic Respiratory Failure

Respiratory Insufficiency/Failure

Chronic Respiratory Disease

Pulmonary Valve Insufficiency

Chronic Disease Of Respiratory System

Respiration Disorders

Respiratory Tract Diseases

Lung Failure Nos

Pulmonary Failure

Arf - [Acute Respiratory Failure]

Acute Respiratory Insufficiency

Acute Pulmonary Insufficiency

Acute Respiration Failure

Chronic Respiration Failure

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus KNG1 VGNC VGNC:102765
Canis familiaris KNG1 VGNC VGNC:53466
Rattus norvegicus KNG1 RGD RGD:2980
Bos taurus KNG1 VGNC VGNC:53586
Macaca mulatta KNG1 VGNC VGNC:74198
Mus musculus KNG1 NCBI NCBI:16644
Others KNG1 NCBI