LDHB - lactate dehydrogenase B Gene

中文名称：乳酸脱氢酶 B

种属: Homo sapiens

同用名: LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281

基因 ID: 3945 | 基因类型: protein coding

关于 LDHB

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,635,342-21,657,842 (from NCBI)

This gene has 11 transcripts (splice variants), 279 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 475.5), heart (RPKM 454.7) and 21 other tissues.

功能概要

该基因编码乳酸脱氢酶的 B 亚基，该酶在糖酵解后过程中催化丙酮酸和乳酸的相互转化，同时伴随 NADH 和 NAD+ 的相互转化。已发现该基因的可变剪接转录物变体。最近的研究表明，通过终止密码子通读机制使用替代的框内翻译终止密码子产生 C 末端扩展的同种型，并且这种同种型位于过氧化物酶体中。该基因的突变与乳酸脱氢酶 B 缺乏症有关。已在 X、5 和 13 号染色体上鉴定出假基因。[RefSeq 提供，2016 年 2 月]

This gene encodes the B subunit of Lactate Dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with Lactate Dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]

LDHB 基因产物(6)

mRNA	Protein	Name
NM_001174097.3	NP_001167568.1	L-lactate dehydrogenase B chain isoform LDHB
NM_001315537.2	NP_001302466.1	L-lactate dehydrogenase B chain isoform LDHBx
NM_001414233.1	NP_001401162.1	L-lactate dehydrogenase B chain isoform 3
NM_001414234.1	NP_001401163.1	L-lactate dehydrogenase B chain isoform 4
NM_001414235.1	NP_001401164.1	L-lactate dehydrogenase B chain isoform 5
NM_002300.8	NP_002291.1	L-lactate dehydrogenase B chain isoform LDHB

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables L-lactate dehydrogenase activity	IDA IDA: 通过直接分析推断	27618187	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in lactate metabolic process	IDA IDA: 通过直接分析推断	15117937	GOA
involved in pyruvate metabolic process	IDA IDA: 通过直接分析推断	15117937	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane raft	IDA IDA: 通过直接分析推断	25204797	GOA
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	27618187	GOA
part of oxidoreductase complex	IPI IPI: 通过物理相互作用推断	15117937	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LDHB 蛋白结构

Ldh_1_N

Ldh_1_C

0
100
200
300
334 a.a.

蛋白主名

其他名称

L-lactate dehydrogenase B chain

LDH heart subunit

LDHB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Array	25416956
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Array	32296183
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Prey Pooling	32296183
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Validated Y2H	25910212
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Bait-Prey Pool	25910212
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Array	25910212
种属内	LDHB	P07195	LDHC	Homo sapiens	P07864	Anti Tag CoIP	33961781
种属内	LDHB	P07195	LDHC	Homo sapiens	P07864	Anti Tag CoIP	28514442
种属内	LDHB	P07195	LDHC	Homo sapiens	P07864	Anti Tag CoIP	35271311
种属内	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Prey Pooling	32296183
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338	Anti Tag CoIP	33961781
种属内	LDHB	P07195	LDHB	Homo sapiens	P07195	Validated Y2H	32296183
种属内	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	25416956
种属内	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	25502805
种属内	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	32296183
种属内	LDHB	P07195	LDHA	Homo sapiens	P00338	Anti Tag CoIP	35271311
种属内	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	31515488
种属内	LDHB	P07195	HTT	Homo sapiens	P42858	Validated Y2H	32814053
种属内	LDHB	P07195	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
种属内	LDHB	P07195	HTT	Homo sapiens	P42858	Y2H Array	32814053
种属内	LDHB	P07195	PEX5	Homo sapiens	P50542	Validated Y2H	25416956
种属内	LDHB	P07195	PEX5	Homo sapiens	P50542	Y2H Array	25416956
种属内	LDHB	P07195	TERF1	Homo sapiens	P54274	BiFC	21044950
种属内	LDHB	P07195	TERF1	Homo sapiens	P54274	Pull Down	21044950
种属内	LDHB	P07195	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
种属内	LDHB	P07195	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LDHB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70265	LDHB Protein, Human (His)	P07195 (M1-L334)	≥95%

LDHB 抗体

目录号	产品名	应用	反应物种
HY-P82325	Lactate Dehydrogenase B Antibody (YA2070)	WB, IHC-P, ICC/IF, IP, FC	Human

关联疾病

疾病名称

别名

Lactate Dehydrogenase B Deficiency

LDHBD	Glycogen Storage Disease Due To Lactate Dehydrogenase H-Subunit Deficiency
Lactate Dehydrogenase-B Deficiency	Ldh Deficiency B
Lactate Dehydrogenase Deficiency Type B	Gsd Due To Lactate Dehydrogenase H-Subunit Deficiency
Glycogenosis Due To Lactate Dehydrogenase H-Subunit Deficiency	Ldh-H Subunit Deficiency

Maxillary Sinus Cancer

Malignant Neoplasm Of Antrum	Malignant Tumor Of The Maxillary Sinus
Maxillary Sinus Carcinoma	Cancer Of Maxillary Sinus
Maxillary Sinus Neoplasms

Maxillary Sinus Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Maxillofacial Sinus

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa 8, Formerly	Rp8, Formerly
Retinitis Pigmentosa 21, Formerly	Rp21, Formerly
Usher Syndrome

Alzheimer Disease 13

AD13	Alzheimer Disease-13
Alzheimer'S Disease 13	Alzheimer'S Disease 13, Late Onset

Parkinson Disease 17

PARK17	Parkinson'S Disease 17
Autosomal Dominant Parkinson Disease 17	Parkinson Disease, Type 17

Paranasal Sinus Cancer

Paranasal Sinus Adenoid Cystic Carcinoma	Paranasal Sinus Mucoepidermoid Carcinoma
Paranasal Sinus Squamous Cell Carcinoma	Paranasal Sinus Neoplasms
Adenoid Cystic Carcinoma Of Accessory Sinus	Adenoid Cystic Carcinoma Of Paranasal Sinus
Epidermoid Carcinoma Of The Paranasal Sinus	Mucoepidermoid Carcinoma Of Accessory Sinus
Paranasal Sinus Adenocarcinoma	Squamous Cell Carcinoma Of Paranasal Sinus
Paranasal Sinus Neoplasm	Adenocarcinoma Of Accessory Sinus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-100742A	(R)-GNE-140	Inhibitor	99.73%	否
HY-W040118	Galloflavin	Inhibitor	99.36%	否
HY-147216	AXKO-0046	Inhibitor	99.77%	否
HY-111108	LDH-IN-1	Inhibitor	99.84%	否
HY-147216A	AXKO-0046 dihydrochloride	Inhibitor	99.68%	否
HY-RS07572	LDHB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-152261	MS6105		99.2%	否
HY-162629	LDHA-IN-7	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	LDHB	VGNC	VGNC:30824
Mus musculus	LDHB	MGD	MGI:96763
Rattus norvegicus	LDHB	RGD	RGD:2997
Others	LDHB	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

LDHB - lactate dehydrogenase B Gene

关于 LDHB

功能概要

LDHB 基因产物(6)

LDHB 蛋白结构

LDHB 蛋白互作信息

重组 LDHB 蛋白

LDHB 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

LDHB - lactate dehydrogenase B Gene

关于 LDHB

功能概要

LDHB 基因产物(6)

LDHB 蛋白结构

LDHB 蛋白互作信息

重组 LDHB 蛋白

LDHB 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z