ASIC1 - acid sensing ion channel subunit 1 Gene

中文名称：酸感应离子通道亚基 1

种属: Homo sapiens

同用名: ASIC; ACCN2; BNaC2

基因 ID: 41 | 基因类型: protein coding

关于 ASIC1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,057,596-50,083,622 (from NCBI)

This gene has 9 transcripts (splice variants), 230 orthologues and 8 paralogues. Biased expression in brain (RPKM 17.4), prostate (RPKM 1.9) and 3 other tissues.

功能概要

该基因编码酸敏感离子通道 (ASIC) 蛋白家族的成员，该蛋白属于退化蛋白/上皮钠通道 (DEG/ENaC) 超家族的一部分。 ASIC 家族的成员对阿米洛利敏感并在神经传递中发挥作用。编码的蛋白质在学习、疼痛传导、触觉以及记忆和恐惧的发展中发挥作用。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial Sodium Channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

ASIC1 基因产物(10)

mRNA	Protein	Name
NM_001095.4	NP_001086.2	acid-sensing ion channel 1 isoform b
NM_001256830.2	NP_001243759.1	acid-sensing ion channel 1 isoform c
NM_001412756.1	NP_001399685.1	acid-sensing ion channel 1 isoform d
NM_001412757.1	NP_001399686.1	acid-sensing ion channel 1 isoform b
NM_001412758.1	NP_001399687.1	acid-sensing ion channel 1 isoform e
NM_001412759.1	NP_001399688.1	acid-sensing ion channel 1 isoform f
NM_001412760.1	NP_001399689.1	acid-sensing ion channel 1 isoform f
NM_001412761.1	NP_001399690.1	acid-sensing ion channel 1 isoform g
NM_001412762.1	NP_001399691.1	acid-sensing ion channel 1 isoform g
NM_020039.4	NP_064423.2	acid-sensing ion channel 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
NOT enables pH-gated monoatomic ion channel activity	IDA IDA: 通过直接分析推断	21036899	GOA
enables pH-gated monoatomic ion channel activity	IDA IDA: 通过直接分析推断	21036899	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11802773	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to pH	IDA IDA: 通过直接分析推断	22760635	GOA
involved in sensory perception of sour taste	IMP IMP: 通过突变表型推断	19812697	GOA
involved in sodium ion transmembrane transport	IDA IDA: 通过直接分析推断	22760635	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	32996060	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	32996060	GOA
is active in plasma membrane	IDA IDA: 通过直接分析推断	21036899	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	22760635	GOA
is active in postsynaptic density membrane	IDA IDA: 通过直接分析推断	32996060	GOA
is active in postsynaptic density membrane	IMP IMP: 通过突变表型推断	32996060	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASIC1 蛋白结构

ASC

0
100
200
300
400
500
528 a.a.

蛋白主名

其他名称

acid-sensing ion channel 1

Cation channel, amiloride-sensitive, neuronal, 2

ASIC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ASIC1	P78348	MGST2	Homo sapiens	Q99735	Y2H Array	32296183
种属内	ASIC1	P78348	MGST2	Homo sapiens	Q99735	Y2H Prey Pooling	32296183
种属内	ASIC1	P78348	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
种属内	ASIC1	P78348	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
种属内	ASIC1	P78348	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
种属内	ASIC1	P78348	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
种属内	ASIC1	P78348	PICK1	Homo sapiens	Q9NRD5	Y2H	11802773

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Pseudohypoaldosteronism, Type I, Autosomal Recessive

Autosomal Recessive Pseudohypoaldosteronism Type 1	PHA1B
Pseudohypoaldosteronism Type 1	Pseudohypoaldosteronism, Type I
Generalized Pha1	Generalized Pseudohypoaldosteronism Type 1
Pseudohypoaldosteronism Type 1 Autosomal Recessive	Pha1
Pseudohypoaldosteronism	Pha I, Autosomal Recessive
Autosomal Recessive Pha 1	Pseudohypoaldosteronism Type 1, Recessive
Pseudohypoaldosteronism Type I	Autosomal Recessive Pha1
Pha Type 1	Pseudohypoaldosteronism 1, Autosomal Recessive
Multisystem Pseudohypoaldosteronism	Pha Type I, Autosomal Recessive
Pseudohypoaldosteronism Type I, Autosomal Recessive

Frozen Shoulder

Adhesive Capsulitis Of Shoulder	Bursitis
Adhesions-Capsulitis,Shoulder	Pericapsulitis Of Shoulder
Duplay Bursitis	Adhesive Shoulder Peritendinitis
Subscapular Adhesion	Shoulder Adhesion
Adhesive Enthesopathy Of Shoulder Region	Adhesive Peritendinitis
Adhesive Shoulder Tenosynovitis	Duplay Periarthritis
Adhesive Shoulder Tendinitis

Ischemia

Acute Coronary Syndrome

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Liddle Syndrome 1

Liddle Syndrome	Pseudoaldosteronism
Liddle'S Syndrome	LIDLS1
Lidls	Pseudohyperaldosteronism
Pseudoprimary Hyperaldosteronism	Pseudohyperaldosteronism Type 1
Liddles Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P1411	Psalmotoxin 1		≥99.0%	否
HY-131879	NS383		99.83%	否
HY-P5174	MitTx	Activator	≥98.0%	否
HY-P1441A	Mambalgin 1 TFA	Inhibitor	95.72%	否
HY-131261	Ibuprofen alcohol		/	否
HY-155017	6-Iodoamiloride	Inhibitor	/	否
HY-164284	LK-2		/	否
HY-P1411A	Psalmotoxin 1 TFA		99.37%	否
HY-P5172	MitTx-alpha	Agonist	/	否
HY-P5780	π-TRTX-Hm3a	Inhibitor	/	否
HY-P5899	Mambalgin-3	Inhibitor	/	否
HY-RS01089	ASIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ASIC1	VGNC	VGNC:38177
Felis catus	ASIC1	VGNC	VGNC:59971
Rattus norvegicus	ASIC1	RGD	RGD:71062
Bos taurus	ASIC1	VGNC	VGNC:26210
Mus musculus	ASIC1	MGD	MGI:1194915
Macaca mulatta	ASIC1	VGNC	VGNC:70035

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ASIC1 - acid sensing ion channel subunit 1 Gene

关于 ASIC1

功能概要

ASIC1 基因产物(10)

ASIC1 蛋白结构

ASIC1 蛋白互作信息

关联疾病

直系同源

热门区域

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ASIC1 - acid sensing ion channel subunit 1 Gene

关于 ASIC1

功能概要

ASIC1 基因产物(10)

ASIC1 蛋白结构

ASIC1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z