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  3. MAGEA4 - MAGE family member A4 Gene

MAGEA4 - MAGE family member A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAGE 家族成员 A4

种属: Homo sapiens

同用名: CT1.4; MAGE4; MAGE4A; MAGE4B; MAGE-41; MAGE-X2

基因 ID: 4103 | 基因类型: protein coding

关于 MAGEA4

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:151,912,474-151,925,170 (from NCBI)

This gene has 18 transcripts (splice variants), 460 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 13.7).

功能概要

该基因是 MAGEA 基因家族的成员。这个家族的成员编码的蛋白质彼此之间有 50% 到 80% 的序列同一性。 MAGEA 基因的启动子和第一个外显子显示出相当大的变异性，表明该基因家族的存在使得相同的功能能够在不同的转录控制下表达。 MAGEA 基因聚集在染色体位置 Xq28。它们与某些遗传性疾病有关，例如先天性角化不良。已发现该基因的几种编码相同蛋白质的变体。[RefSeq 提供，2020 年 8 月]

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each Other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2020]

MAGEA4 基因产物(11)

mRNA Protein Name
NM_001011548.1 NP_001011548.1 melanoma-associated antigen 4
NM_001011549.1 NP_001011549.1 melanoma-associated antigen 4
NM_001011550.1 NP_001011550.1 melanoma-associated antigen 4
NM_001386196.1 NP_001373125.1 melanoma-associated antigen 4
NM_001386197.1 NP_001373126.1 melanoma-associated antigen 4
NM_001386198.1 NP_001373127.1 melanoma-associated antigen 4
NM_001386199.1 NP_001373128.1 melanoma-associated antigen 4
NM_001386200.1 NP_001373129.1 melanoma-associated antigen 4
NM_001386202.1 NP_001373131.1 melanoma-associated antigen 4
NM_001386203.1 NP_001373132.1 melanoma-associated antigen 4
NM_002362.4 NP_002353.3 melanoma-associated antigen 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12525503 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
22842486 GOA
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
22842486 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAGEA4 蛋白结构

MAGE_N

MAGE_N: Melanoma associated antigen family N terminal (4 - 99)

MAGE

MAGE: MAGE family (118 - 287)

  • 0
  • 100
  • 200
  • 317 a.a.
蛋白主名 其他名称

melanoma-associated antigen 4

MAGE-4 antigen

MAGEA4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAGEA4 P43358 UVSSA Homo sapiens Q2YD98
Validated Y2H
32296183
种属内
MAGEA4 P43358 TRIM69 Homo sapiens Q86WT6-2
Validated Y2H
32296183
种属内
MAGEA4 P43358 HDDC3 Homo sapiens Q8N4P3-2
Validated Y2H
32296183
种属内
MAGEA4 P43358 PUDP Homo sapiens Q08623
Validated Y2H
32296183
种属内
MAGEA4 P43358 UBXN6 Homo sapiens Q9BZV1
Validated Y2H
32296183
种属内
MAGEA4 P43358 RAD18 Homo sapiens Q9NS91
Anti Tag CoIP
33961781
种属内
MAGEA4 P43358 RAD18 Homo sapiens Q9NS91
Validated Y2H
32296183
种属内
MAGEA4 P43358 RAD18 Homo sapiens Q9NS91
Anti Tag CoIP
28514442
种属内
MAGEA4 P43358 AMOT Homo sapiens Q4VCS5
Y2H Array
31515488
种属内
MAGEA4 P43358 AMOT Homo sapiens Q4VCS5
Anti Tag CoIP
33961781
种属内
MAGEA4 P43358 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
种属内
MAGEA4 P43358 TSPYL4 Homo sapiens Q9UJ04
Anti Tag CoIP
33961781
种属内
MAGEA4 P43358 TSPYL4 Homo sapiens Q9UJ04
Validated Y2H
32296183
种属内
MAGEA4 P43358 TSPYL4 Homo sapiens Q9UJ04
Anti Tag CoIP
28514442
种属内
MAGEA4 P43358 ZBTB17 Homo sapiens Q13105
Anti Tag CoIP
14739298
种属内
MAGEA4 P43358 ZNF576 Homo sapiens Q9H609
Validated Y2H
32296183
种属内
MAGEA4 P43358 TSPYL Homo sapiens Q6FI91
Validated Y2H
32296183
种属内
MAGEA4 P43358 UQCRB Homo sapiens P14927
Anti Tag CoIP
33961781
种属内
MAGEA4 P43358 UQCRB Homo sapiens P14927
Y2H Pooling
16189514
种属内
MAGEA4 P43358 UQCRB Homo sapiens P14927
Anti Tag CoIP
28514442
种属内
MAGEA4 P43358 LDLRAP1 Homo sapiens Q5SW96
Validated Y2H
32296183
种属内
MAGEA4 P43358 TRIM69 Homo sapiens Q86WT6
Y2H Array
31515488
种属内
MAGEA4 P43358 TRIM69 Homo sapiens Q86WT6
Y2H Pooling
16189514
种属内
MAGEA4 P43358 TEKT4 Homo sapiens Q8WW24
Y2H Array
31515488
种属内
MAGEA4 P43358 TEKT4 Homo sapiens Q8WW24
Validated Y2H
32296183
种属内
MAGEA4 P43358 TEKT4 Homo sapiens Q8WW24
Y2H Pooling
16189514
种属内
MAGEA4 P43358 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
种属内
MAGEA4 P43358 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MAGEA4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700420 MAGEA4 Protein, Human (HEK293, His) P43358 (M1-V317) ≥95%

关联疾病

疾病名称 别名
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Seminoma

Seminoma, Pure
Squamous Cell Carcinoma

Epidermoid Carcinoma

Squamous Cell Cancer

Carcinoma, Squamous Cell

Squamous Cell Skin Cancer

Malignant Squamous Cell Tumor

Squamous Carcinoma

Squamous Cell Epithelioma

Carcinoma Squamous Cell

Neoplasms, Squamous Cell

Squamous Cell Carcinoma - Category

Malignant Squamous Cell Neoplasm

Squamous Cell Carcinoma Of Skin
Spermatocytoma

Spermatocytic Seminoma
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Testicular Spermatocytic Seminoma

Spermatocytic Seminoma
Testicular Leukemia
Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome
Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm
Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor
Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders
Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma

Liposarcoma, Myxoid

Mrcls

Myxoliposarcoma

MXLIPO

Liposarcoma Myxoid

Liposarcoma
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Sarcoma, Synovial

Synovial Sarcoma

Synovialosarcoma

Synovial Cell Sarcoma

Sarcoma Synovial
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2269 MAIT-203 / 否
HY-RS07969 MAGEA4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Others MAGEA4 NCBI
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