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  3. MCM3 - minichromosome maintenance complex component 3 Gene

MCM3 - minichromosome maintenance complex component 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：微型染色体维护复杂组件 3

种属: Homo sapiens

同用名: HCC5; P1.h; RLFB; P1-MCM3

基因 ID: 4172 | 基因类型: protein coding

关于 MCM3

Cytogenetic location: 6p12.2 Genomic coordinates (GRCh38): 6:52,264,015-52,284,742 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 8 paralogues. Ubiquitous expression in lymph node (RPKM 33.0), appendix (RPKM 23.5) and 24 other tissues.

功能概要

由该基因编码的蛋白质是高度保守的微型染色体维持蛋白 (MCM) 之一，参与真核基因组复制的启动。由 MCM 蛋白形成的六聚体蛋白复合物是复制前复合物 (pre_RC) 的关键组成部分，可能参与复制叉的形成和其他 DNA 复制相关蛋白的募集。这种蛋白质是由 MCM2-7 组成的蛋白质复合物的一个亚基。它已被证明可以直接与 MCM5/CDC46 交互。该蛋白质还与 MCM3AP (一种染色质相关的乙酰转移酶) 相互作用并被乙酰化。这种蛋白质的乙酰化抑制 DNA 复制的启动和细胞周期进程。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2018 年 10 月]

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2018]

MCM3 基因产物(9)

mRNA Protein Name
NM_001270472.3 NP_001257401.2 DNA replication licensing factor MCM3 isoform 2
NM_001366369.2 NP_001353298.1 DNA replication licensing factor MCM3 isoform 3
NM_001366370.2 NP_001353299.1 DNA replication licensing factor MCM3 isoform 4
NM_001366371.2 NP_001353300.1 DNA replication licensing factor MCM3 isoform 5
NM_001366372.2 NP_001353301.1 DNA replication licensing factor MCM3 isoform 6
NM_001366373.2 NP_001353302.1 DNA replication licensing factor MCM3 isoform 7
NM_001366374.2 NP_001353303.1 DNA replication licensing factor MCM3 isoform 8
NM_001366375.2 NP_001353304.1 DNA replication licensing factor MCM3 isoform 9
NM_002388.6 NP_002379.4 DNA replication licensing factor MCM3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12364596 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA unwinding involved in DNA replication IDA
IDA: 通过直接分析推断
22474384 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CMG complex IPI
IPI: 通过物理相互作用推断
22474384 GOA
part of MCM complex IDA
IDA: 通过直接分析推断
17296731 GOA
part of MCM complex IPI
IPI: 通过物理相互作用推断
22540012 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
21383955 GOA
located in nucleus IDA
IDA: 通过直接分析推断
20531406 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20531406 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MCM3 蛋白结构

MCM_N

MCM_N: MCM N-terminal domain (16 - 129)

MCM

MCM: MCM2/3/5 family (282 - 651)

  • 0
  • 200
  • 400
  • 600
  • 808 a.a.
蛋白主名 其他名称

DNA replication licensing factor MCM3

DNA polymerase alpha holoenzyme-associated protein P1

关联疾病

疾病名称 别名
Anaplastic Astrocytoma

Grade Iii Astrocytoma

Astrocytoma, Anaplastic

Grade Iii Astrocytic Tumor
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma
Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome

Ear, Patella, Short Stature Syndrome

Microtia, Absent Patellae, Micrognathia Syndrome

MGORS1

Eps

Ear-Patella-Short Stature Syndrome

Ear Patella Short Stature Syndrome

Microtia Absent Patellae Micrognathia Syndrome

Meier-Gorlin Syndrome, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08235 MCM3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08236 MCM3AP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MCM3 MGD MGI:101845
Canis familiaris MCM3 VGNC VGNC:43082
Felis catus MCM3 VGNC VGNC:68213
Macaca mulatta MCM3 VGNC VGNC:74681
Rattus norvegicus MCM3 RGD RGD:1305168
Bos taurus MCM3 VGNC VGNC:31309
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