1. Gene
  2. MLN - motilin Gene

MLN - motilin Gene

中文名称:促胃动素

种属: Homo sapiens

基因 ID: 4295 | 基因类型: protein coding

关于 MLN

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:33,794,673-33,804,003 (from NCBI)

This gene has 3 transcripts (splice variants) and 92 orthologues. Restricted expression toward duodenum (RPKM 82.5).

功能概要

该基因编码一种小肽激素,该激素由小肠细胞分泌以调节胃肠收缩和运动。分泌蛋白的蛋白水解加工产生成熟肽和称为促胃动素相关肽 (MAP) 的副产物。已为该基因发现编码不同前原蛋白同种型但相同成熟肽的三种转录物变体。[RefSeq 提供,2010 年 5 月]

This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]

MLN 基因产物(3)

mRNA Protein Name
NM_001040109.2 NP_001035198.1 promotilin isoform 2 preproprotein
NM_001184698.2 NP_001171627.1 promotilin isoform 3 preproprotein
NM_002418.3 NP_002409.1 promotilin isoform 1 preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables motilin receptor binding IPI
IPI: 通过物理相互作用推断
10381885 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

MLN 蛋白结构

Motilin_ghrelin

Motilin_ghrelin: Motilin/ghrelin (27 - 53)

Motilin_assoc

Motilin_assoc: Motilin/ghrelin-associated peptide (62 - 113)

  • 0
  • 100
  • 115 a.a.
蛋白主名 其他名称

promotilin

prepromotilin

重组 MLN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70285 Promotilin/MLN Protein, Human (HEK293, His) P12872-1 (F26-K115) ≥95%

关联疾病

疾病名称 别名
Gastroparesis

Gastroparesis Syndrome

Delayed Gastric Emptying

Gastric Atonia

Gastroparalysis

Duodenogastric Reflux
Functional Gastric Disease
Pylorospasm
Dumping Syndrome

Jejunal Syndrome

Dumping

Dumping Syndrome

Postgastrectomy Syndromes

Postgastric Surgery Syndrome

Postgastrectomy Syndrome

Post Cibal Syndrome

Postgastrectomy Dumping Syndrome

Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease

Neurogenic Bowel
Pyloric Stenosis
Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Constipation
Zollinger-Ellison Syndrome

Gastrinoma

Pancreatic Ulcerogenic Tumor Syndrome

Z E Syndrome

Zes

Ze - [Zollinger-Ellison] Syndrome

Hypertrophic Pyloric Stenosis

Congenital Hypertrophic Pyloric Stenosis

Pyloric Stenosis, Hypertrophic

Congenital Or Infantile Stricture Of Pylorus

Achalasia Of The Pylorus

Congenital Hypertrophy Of The Pylorus

Infantile Hypertrophy Of The Pylorus

Infantile Constriction Of The Pylorus

Congenital Stenosis Of The Pylorus

Congenital Constriction Of The Pylorus

Congenital Stricture Of The Pylorus

Infantile Hypertrophic Pyloric Stenosis

Infantile Stenosis Of The Pylorus

Infantile Stricture Of The Pylorus

Congenital Or Infantile Constriction Of Pylorus

Infantile Pyloric Obstruction

Infantile Pyloric Hypertrophy

Pylorus Achalasia

Pyloric Constriction

Infantile Pyloric Stricture

Infantile Pyloric Stenosis

Congenital Spasm Of Pylorus

Congenital Pylorospasm

Congenital Pyloric Stricture

Congenital Pyloric Spasm

Congenital Or Infantile Spasm Of Pylorus

Congenital Or Infantile Obstruction Of Pylorus

Congenital Pyloric Stenosis

Functional Colonic Disease

Colonic Diseases, Functional

Irritable Bowel Syndrome

Irritable Colon

Psychogenic Ibs

Ibs - [Irritable Bowel Syndrome]

Spastic Bowel Syndrome

Gallbladder Disease

Gallbladder Diseases

Gall Bladder

Gall Bladder Diseases

Abnormal Gallbladder Function

Space Motion Sickness
Acute Porphyria

Porphyrias, Hepatic

Hepatic Porphyria

Porphyria Hepatic

Acute Intermittent Porphyria

Duodenal Ulcer

Stress Ulcer

Curling Ulcer

Stress Ulcer Of Stomach

Curling'S Ulcers

Duodenal Ulcer Disease

Duodenal Ulcers

Duodenal Peptic Ulcer

Postgastrectomy Syndrome

Postgastrectomy Syndromes

Postgastric Surgery Syndrome

Rumination Disorder

Rumination Syndrome

Psychogenic Rumination

Rumination Disorders

Paralytic Ileus

Adynamic Ileus

Paralytic Ileus Of Bowel

Ileus Nos

Paralysis Of Bowel

Paralysis Of Intestine

Adynamic Intestinal Obstruction

Paralytic Intestinal Ileus

Colonic Pseudo-Obstruction

Primary Chronic Pseudo-Obstruction Of Colon

Functional Diarrhea

Functional Diarrhoea

Gastrointestinal System Disease

Gastrointestinal Disease

Gastrointestinal Diseases

Alimentary System Disease

Digestive System Disorder

Gastroenteropathy

Gastrointestinal Disorder

Git Disease

Digestive System Diseases

Gastrointestinal Disorders

Digestive System Disease

Digestive System Disorders

Pneumatosis Cystoides Intestinalis
Postcholecystectomy Syndrome

Post Cholecystectomy Syndrome

Gastroenteritis

Cholera Morbus

Infectious Colitis, Enteritis And Gastroenteritis

Enteritis Due To Astrovirus

Rotaviral Gastroenteritis

Viral Gastroenteritis Due To Rotavirus

Esophagitis

Acute Esophagitis

Perianal Hematoma

External Thrombosed Haemorrhoids

Thrombosed External Hemorrhoids

Dyskinesia Of Esophagus

Esophageal Motility Disorders

Dyskinesia Of Oesophagus

Esophageal Dysmotility

Esophageal Motility Disorder

Oesophageal Dysmotility

Oesophageal Motor Disorder

Esophageal Spasm

Blind Loop Syndrome

Bacterial Overgrowth Syndrome

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Volvulus Of Midgut

Volvulus

Intestinal Volvulus

Intestinal Malrotation, Familial

Familial Intestinal Malrotation

Twist Of Intestine, Bowel, Or Colon

Peptic Esophagitis

Reflux Esophagitis

Peptic Reflux Disease

Reflux Oesophagitis

Esophagitis, Peptic

Gastro-Esophageal Reflux Disease With Esophagitis

Hernia, Hiatus

Hiatal Hernia

Hiatus Hernia

Diaphragmatic - Hiatus -Hernia

Hernia, Hiatal

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications

Intestinal Pseudo-Obstruction

Chronic Intestinal Pseudoobstruction

Chronic Intestinal Pseudo-Obstruction

Cipo

Neuronal Intestinal Dysplasia

Hollow Visceral Myopathy

Familial Visceral Neuropathy

Paralytic Ileus

Intestinal Pseudoobstruction

Chronic Idiopathic Intestinal Pseudo-Obstruction

Ciip

Congenital Short Bowel Syndrome

Enteric Neuropathy

Familial Visceral Myopathy

Ipo

Pseudo-Obstruction Of Intestine

Pseudointestinal Obstruction Syndrome

Pseudoobstructive Syndrome

Congenital Idiopathic Intestinal Pseudoobstruction

Visceral Myopathy, Familial

Capillary Malformations, Congenital

Familial Multiple Nevi Flammei

Nevi Flammei, Familial Multiple

CMC

Port-Wine Stain

Capillary Malformations

Cmal

Familial Multiple Port-Wine Stains

Capillary Malformation

Capillary Malformations, Congenital, 1, Somatic, Mosaic

Congenital Capillary Malformations

Port-Wine Stain Familial Multiple

Hereditary Capillary Malformations

Capillary Malformations, Hereditary

Capillary Malformations, Congenital, Type 1, Somatic, Mosaic

Strawberry Nevus Of Skin

Naevus Flammeus

Diabetes Mellitus

Diabetes

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MLN VGNC VGNC:74884
Rattus norvegicus MLN RGD RGD:1642907
Felis catus MLN VGNC VGNC:97180
Canis familiaris MLN VGNC VGNC:54970
Bos taurus MLN VGNC VGNC:31505
Macaca fascicularis MLN NCBI NCBI:102146298
Mus musculus MLN NCBI
Others MLN NCBI