2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. XR11576

XR11576 (MLN576) 是一种具有口服活性的拓扑异构酶 I 和 II 抑制剂。XR11576 显示针对人和鼠肿瘤细胞系的细胞毒性 (IC50: 6-47 nM)。

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XR11576 Chemical Structure

XR11576 Chemical Structure

CAS No. : 346689-77-8

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XR11576 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
COR-L23 IC50
10.1 nM
Compound: XR-11576
Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line
[PMID: 11806724]
NCI-H69 IC50
23 nM
Compound: XR-11576
Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line
[PMID: 11806724]
NCI-H69 IC50
29 nM
Compound: XR-11576
Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4
[PMID: 11806724]
分子量

388.46

Formula

C23H24N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

XR11576 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XR11576346689-77-8MLN576XR 11576XR-11576MLN 576MLN-576TopoisomeraseanticancerMDRlung cancerMC26HT29colon carcinoma,Inhibitorinhibitorinhibit

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目录号：
HY-123143
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