NFKBIB - NFKB inhibitor beta Gene

中文名称：NFKB 抑制因子 β

种属: Homo sapiens

同用名: IKBB; TRIP9

关于 NFKBIB

功能概要

该基因编码的蛋白质属于 NF-kappa-B 抑制剂家族，通过与 NF-kappa-B 复合并将其捕获在细胞质中来抑制 NF-kappa-B。激酶对这些蛋白质上的丝氨酸残基的磷酸化标志着它们通过泛素化途径被破坏，从而允许激活 NF-kappa-B，NF-kappa-B 易位到细胞核以作为转录因子发挥作用。已发现该基因的可变剪接转录本变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]