NQO2 - N-ribosyldihydronicotinamide:quinone reductase 2 Gene

中文名称：N-核糖基二氢烟酰胺：醌还原酶 2

种属: Homo sapiens

同用名: QR2; DHQV; DIA6; NMOR2

基因 ID: 4835 | 基因类型: protein coding

关于 NQO2

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:2,999,894-3,019,755 (from NCBI)

This gene has 9 transcripts (splice variants), 258 orthologues, 1 paralogue and is associated with 1 phenotype. Broad expression in kidney (RPKM 43.3), fat (RPKM 18.6) and 24 other tissues.

功能概要

该基因编码硫氧还蛋白酶家族的一个成员。它是一种细胞溶质和普遍表达的黄素蛋白，可催化醌底物的双电子还原，并使用二氢烟酰胺核苷作为还原辅酶。该基因的突变与神经退行性疾病和几种癌症有关。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of the thioredoxin family of Enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

NQO2 基因产物(4)

mRNA	Protein	Name
NM_000904.6	NP_000895.2	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
NM_001290221.2	NP_001277150.1	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1
NM_001290222.2	NP_001277151.1	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2
NM_001318940.2	NP_001305869.1	ribosyldihydronicotinamide dehydrogenase [quinone] isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables FAD binding	IDA IDA: 通过直接分析推断	18254726	GOA
enables chloride ion binding	IDA IDA: 通过直接分析推断	18254726	GOA
enables dihydronicotinamide riboside quinone reductase activity	IDA IDA: 通过直接分析推断	18254726	GOA
enables electron transfer activity	IDA IDA: 通过直接分析推断	10945627	GOA
enables melatonin binding	IDA IDA: 通过直接分析推断	18254726	GOA
enables oxidoreductase activity	IDA IDA: 通过直接分析推断	10945627	GOA
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	IDA IDA: 通过直接分析推断	10945627	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	18254726	GOA
enables resveratrol binding	IDA IDA: 通过直接分析推断	18254726	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	18254726	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in quinone catabolic process	IDA IDA: 通过直接分析推断	18254726	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytosol	IDA IDA: 通过直接分析推断	10945627	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NQO2 蛋白结构

Flavodoxin_2

0
100
200
231 a.a.

蛋白主名

其他名称

ribosyldihydronicotinamide dehydrogenase [quinone]

NAD(P)H dehydrogenase, quinone 2

NQO2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NQO2	P16083	LRRC7	Homo sapiens	A1L1C6	Y2H Prey Pooling	25416956
种属内	NQO2	P16083	LRRC7	Homo sapiens	A1L1C6	Y2H Array	25416956
种属内	NQO2	P16083	GORASP2	Homo sapiens	Q9H8Y8	Y2H Pooling	16189514
种属内	NQO2	P16083	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
种属内	NQO2	P16083	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	31515488
种属内	NQO2	P16083	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
种属内	NQO2	P16083	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
种属内	NQO2	P16083	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
种属内	NQO2	P16083	SPG21	Homo sapiens	Q9NZD8	Y2H Prey Pooling	32296183
种属内	NQO2	P16083	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
种属内	NQO2	P16083	SPG21	Homo sapiens	Q9NZD8	Y2H Array	32296183
种属内	NQO2	P16083	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

NQO2 抗体

目录号	产品名	应用	反应物种
HY-P82542	NQO2 Antibody (YA2287)	WB, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Familial Adenomatous Polyposis 3

FAP3	Nthl1-Related Attenuated Familial Adenomatous Polyposis
Nthl1-Related Afap	Nthl1-Related Attenuated Fap

Granulocytopenia

Agranulocytosis

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-145820	Tubulin inhibitor 14		/	Phase 3

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-77521	Dabigatran ethyl ester hydrochloride	Inhibitor	/	否
HY-RS09524	NQO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	NQO2	VGNC	VGNC:75500
Bos taurus	NQO2	VGNC	VGNC:32225
Felis catus	NQO2	VGNC	VGNC:68506
Canis familiaris	NQO2	VGNC	VGNC:59138
Mus musculus	NQO2	MGD	MGI:104513
Rattus norvegicus	NQO2	RGD	RGD:1303320

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