PRDX1 - peroxiredoxin 1 Gene

中文名称：过氧化物酶 1

种属: Homo sapiens

同用名: PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A

基因 ID: 5052 | 基因类型: protein coding

关于 PRDX1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,511,051-45,522,890 (from NCBI)

This gene has 6 transcripts (splice variants), 246 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 269.3), kidney (RPKM 192.7) and 24 other tissues.

功能概要

该基因编码抗氧化酶过氧化物酶家族的成员，可减少过氧化氢和烷基氢过氧化物。编码的蛋白质可能在细胞中发挥抗氧化保护作用，并可能有助于 CD8 (+) T 细胞的抗病毒活性。这种蛋白质可能具有增殖作用，并在癌症发展或进展中发挥作用。已经为该基因鉴定了编码相同蛋白质的四种转录物变体。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the Antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in Cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

PRDX1 基因产物(4)

mRNA	Protein	Name
NM_001202431.2	NP_001189360.1	peroxiredoxin-1
NM_002574.4	NP_002565.1	peroxiredoxin-1
NM_181696.3	NP_859047.1	peroxiredoxin-1
NM_181697.3	NP_859048.1	peroxiredoxin-1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables peroxidase activity	IDA IDA: 通过直接分析推断	11986303	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15105503	GOA
enables thioredoxin peroxidase activity	IDA IDA: 通过直接分析推断	18606987	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within hydrogen peroxide catabolic process	IDA IDA: 通过直接分析推断	11986303	GOA
involved in hydrogen peroxide catabolic process	IDA IDA: 通过直接分析推断	18606987	GOA
involved in natural killer cell activation	IDA IDA: 通过直接分析推断	8462106	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	17603937	GOA
located in nucleus	IDA IDA: 通过直接分析推断	17603937	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRDX1 蛋白结构

AhpC-TSA

1-cysPrx_C

0
100
199 a.a.

蛋白主名

其他名称

peroxiredoxin-1

epididymis secretory sperm binding protein

PRDX1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PRDX1	Q06830	DPP9	Homo sapiens	Q86TI2-2	Validated Y2H	32814053
种属内	PRDX1	Q06830	DPP9	Homo sapiens	Q86TI2-2	Y2H Pooling	32814053
种属内	PRDX1	Q06830	DPP9	Homo sapiens	Q86TI2-2	Y2H Array	32814053
种属内	PRDX1	Q06830	PRDX4	Homo sapiens	Q13162	Y2H	21988832
种属内	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Anti Tag CoIP	23386615
种属内	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Y2H	23386615
种属内	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Pull Down	23386615
种属内	PRDX1	Q06830	STK4	Homo sapiens	Q13043	Protein Kinase Assay	23386615
种属内	PRDX1	Q06830	AR	Homo sapiens	P10275	Anti Bait CoIP	17909037
种属内	PRDX1	Q06830	PTEN	Homo sapiens	P60484	Anti Bait CoIP	19369943
种属内	PRDX1	Q06830	PTEN	Homo sapiens	P60484	Anti Tag CoIP	19369943
种属内	PRDX1	Q06830	PTEN	Homo sapiens	P60484	Pull Down	19369943
种属内	PRDX1	Q06830	TERF1	Homo sapiens	P54274	Pull Down	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRDX1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71231	PRDX1 Protein, Human (His)	Q06830 (M1-K199)	≥95%

PRDX1 抗体

目录号	产品名	应用	反应物种
HY-P80782	Peroxiredoxin 1 Antibody (YA692)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Methylmalonic Aciduria And Homocystinuria, Cblc Type

MAHCC	Vitamin B12 Metabolic Defect With Combined Deficiency Of Methylmalonyl-Coa Mutase And Homocysteine:Methyltetrahydrofolate Methyltransferase
Methylmalonic Aciduria And Homocystinuria, Cblc Type, Digenic	Methylmalonic Aciduria And Homocystinuria Type Cblc
Cobalamin C Disease	Methylmalonic Acidemia With Homocystinuria Cblc
Methylmalonic Acidemia And Homocystinuria, Cblc Type	Methylmalonic Aciduria And Homocystinuria, Vitamin B12-Responsive
Cobalamin C Deficiency	Methylmalonic Acidemia With Homocystinuria, Type Cblc
Cblc Defect	Cobalamin C Defect
Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblc	Methylmalonic Aciduria With Homocystinuria, Type Cblc
Methylmalonic Acidemia And Homocystinuria Cblc Type	Methylmalonic Aciduria And Homocystinuria Vitamin B12-Responsive
Aciduria, Methylmalonic, And Homocystinuria, Cblc Type	Methylmalonic Acidemia With Homocystinuria

Anthrax Disease

Anthrax	Ragpicker'S Disease
Black Baine	Malignant Edema
Malignant Pustule	Siberian Plague
Wool Sorter'S Disease	Gas Gangrene
Cutaneous Anthrax	Anthrax Infection
Splenic Fever

Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax

Inhalation Anthrax

Pulmonary Anthrax	Respiratory Anthrax
Inhalational Anthrax	Wool-Sorters' Disease
Woolsorters' Disease	Inhalation Anthrax Disease
Respiratory Anthrax Disease

Gastrointestinal Anthrax

Parkinson Disease 17

PARK17	Parkinson'S Disease 17
Autosomal Dominant Parkinson Disease 17	Parkinson Disease, Type 17

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-149394	PRDX1-IN-1		98.04%	否
HY-122936	Tanshindiol C		98.47%	否
HY-158368	PRDX1-IN-2	Inhibitor	/	否
HY-RS11074	PRDX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	PRDX1	MGD	MGI:99523
Rattus norvegicus	PRDX1	RGD	RGD:620039
Macaca mulatta	PRDX1	VGNC	VGNC:100047
Felis catus	PRDX1	VGNC	VGNC:107605
Bos taurus	PRDX1	VGNC	VGNC:33299
Others	PRDX1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRDX1 - peroxiredoxin 1 Gene

关于 PRDX1

功能概要

PRDX1 基因产物(4)

PRDX1 蛋白结构

PRDX1 蛋白互作信息

重组 PRDX1 蛋白

PRDX1 抗体

关联疾病

直系同源

热门区域

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PRDX1 - peroxiredoxin 1 Gene

关于 PRDX1

功能概要

PRDX1 基因产物(4)

PRDX1 蛋白结构

PRDX1 蛋白互作信息

重组 PRDX1 蛋白

PRDX1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z