2. Gene
  3. PRDX1 - peroxiredoxin 1 Gene

PRDX1 - peroxiredoxin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：过氧化物酶 1

种属: Homo sapiens

同用名: PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A

基因 ID: 5052 | 基因类型: protein coding

关于 PRDX1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:45,511,051-45,522,890 (from NCBI)

This gene has 6 transcripts (splice variants), 246 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 269.3), kidney (RPKM 192.7) and 24 other tissues.

功能概要

该基因编码抗氧化酶过氧化物酶家族的成员，可减少过氧化氢和烷基氢过氧化物。编码的蛋白质可能在细胞中发挥抗氧化保护作用，并可能有助于 CD8 (+) T 细胞的抗病毒活性。这种蛋白质可能具有增殖作用，并在癌症发展或进展中发挥作用。已经为该基因鉴定了编码相同蛋白质的四种转录物变体。[RefSeq 提供，2011 年 1 月]

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the Antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in Cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]

PRDX1 基因产物(4)

mRNA Protein Name
NM_001202431.2 NP_001189360.1 peroxiredoxin-1
NM_002574.4 NP_002565.1 peroxiredoxin-1
NM_181696.3 NP_859047.1 peroxiredoxin-1
NM_181697.3 NP_859048.1 peroxiredoxin-1

PRDX1 蛋白结构

AhpC-TSA

AhpC-TSA: AhpC/TSA family (8 - 141)

1-cysPrx_C

1-cysPrx_C: C-terminal domain of 1-Cys peroxiredoxin (162 - 197)

  • 0
  • 100
  • 199 a.a.
蛋白主名 其他名称

peroxiredoxin-1

epididymis secretory sperm binding protein

重组 PRDX1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71231 PRDX1 Protein, Human (His) Q06830 (M1-K199) ≥95%

关联疾病

疾病名称 别名
Methylmalonic Aciduria And Homocystinuria, Cblc Type

MAHCC

Vitamin B12 Metabolic Defect With Combined Deficiency Of Methylmalonyl-Coa Mutase And Homocysteine:Methyltetrahydrofolate Methyltransferase

Methylmalonic Aciduria And Homocystinuria, Cblc Type, Digenic

Methylmalonic Aciduria And Homocystinuria Type Cblc

Cobalamin C Disease

Methylmalonic Acidemia With Homocystinuria Cblc

Methylmalonic Acidemia And Homocystinuria, Cblc Type

Methylmalonic Aciduria And Homocystinuria, Vitamin B12-Responsive

Cobalamin C Deficiency

Methylmalonic Acidemia With Homocystinuria, Type Cblc

Cblc Defect

Cobalamin C Defect

Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblc

Methylmalonic Aciduria With Homocystinuria, Type Cblc

Methylmalonic Acidemia And Homocystinuria Cblc Type

Methylmalonic Aciduria And Homocystinuria Vitamin B12-Responsive

Aciduria, Methylmalonic, And Homocystinuria, Cblc Type

Methylmalonic Acidemia With Homocystinuria
Anthrax Disease

Anthrax

Ragpicker'S Disease

Black Baine

Malignant Edema

Malignant Pustule

Siberian Plague

Wool Sorter'S Disease

Gas Gangrene

Cutaneous Anthrax

Anthrax Infection

Splenic Fever
Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax
Inhalation Anthrax

Pulmonary Anthrax

Respiratory Anthrax

Inhalational Anthrax

Wool-Sorters' Disease

Woolsorters' Disease

Inhalation Anthrax Disease

Respiratory Anthrax Disease
Gastrointestinal Anthrax
Parkinson Disease 17

PARK17

Parkinson'S Disease 17

Autosomal Dominant Parkinson Disease 17

Parkinson Disease, Type 17
Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149394 PRDX1-IN-1 98.04% 否
HY-122936 Tanshindiol C 98.47% 否
HY-158368 PRDX1-IN-2 Inhibitor / 否
HY-RS11074 PRDX1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRDX1 MGD MGI:99523
Rattus norvegicus PRDX1 RGD RGD:620039
Macaca mulatta PRDX1 VGNC VGNC:100047
Felis catus PRDX1 VGNC VGNC:107605
Bos taurus PRDX1 VGNC VGNC:33299
Others PRDX1 NCBI
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