2. Gene
  3. LAP3 - leucine aminopeptidase 3 Gene

LAP3 - leucine aminopeptidase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：亮氨酸氨肽酶 3

种属: Homo sapiens

同用名: LAP; PEPS; LAPEP; HEL-S-106

基因 ID: 51056 | 基因类型: protein coding

关于 LAP3

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,577,198-17,607,970 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 73.5), lymph node (RPKM 68.4) and 24 other tissues.

功能概要

预测启用肽酶活性。预计参与蛋白水解。位于胞质溶胶中；中体;和核质。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol; midbody; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LAP3 基因产物(1)

mRNA Protein Name
NM_015907.3 NP_056991.2 cytosol aminopeptidase
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LAP3 蛋白结构

Peptidase_M17_N

Peptidase_M17_N: Cytosol aminopeptidase family, N-terminal domain (37 - 169)

Peptidase_M17

Peptidase_M17: Cytosol aminopeptidase family, catalytic domain (196 - 509)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
蛋白主名 其他名称

cytosol aminopeptidase

cysteinylglycine-S-conjugate dipeptidase

LAP3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LAP3 P28838 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
种属内
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
种属内
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
种属内
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
种属内
LAP3 P28838 ZYX Homo sapiens Q15942
Y2H Array
32296183
种属内
LAP3 P28838 ZYX Homo sapiens Q15942
Y2H Prey Pooling
32296183
种属内
LAP3 P28838 ZYX Homo sapiens Q15942
Validated Y2H
32296183
种属内
LAP3 P28838 ZNF76 Homo sapiens P36508
Validated Y2H
32296183
种属内
LAP3 P28838 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
种属内
LAP3 P28838 CBX3 Homo sapiens Q13185
Y2H Array
32296183
种属内
LAP3 P28838 CBX3 Homo sapiens Q13185
Y2H Prey Pooling
32296183
种属内
LAP3 P28838 CBX3 Homo sapiens Q13185
Validated Y2H
32296183
种属内
LAP3 P28838 CBX5 Homo sapiens P45973
Validated Y2H
32296183
种属内
LAP3 P28838 CBX5 Homo sapiens P45973
Y2H Array
32296183
种属内
LAP3 P28838 PIK3R3 Homo sapiens Q92569
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LAP3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74780 LAP3 Protein, Human (HEK293, His) P28838/NP_056991.2 (M1-A519) ≥95%

关联疾病

疾病名称 别名
Bacterial Vaginosis

Vaginosis, Bacterial
Haverhill Fever

Streptobacillosis

Streptobacillary Rat-Bite Fever

Streptobacillary Fever

Rat-Bite Fever Due To Streptobacillus Moniliformis

Erythema Arthriticum Epidemicum

Epidemic Arthritic Erythema
Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome
Syphilitic Meningitis

Syphilitic Aseptic Meningitis

Meningeal Syphilis

Meningitis, Syphilitic
Vaginitis

Infective Vaginitis

Inflammation Of Vagina

Colpitis

Vaginal Inflammation

Vaginitis Nos
Vaginal Disease

Vaginal Diseases
Vaginal Discharge
Specific Language Impairment

Language Impairment, Specific
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-137844 L-Leucine-7-amido-4-methylcoumarin hydrochloride 99.17% 否
HY-108546 L-AP3 Antagonist / 否
HY-RS07520 LAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LAP3 VGNC VGNC:78519
Mus musculus LAP3 MGD MGI:1914238
Bos taurus LAP3 VGNC VGNC:30786
Macaca mulatta LAP3 VGNC VGNC:97784
Canis familiaris LAP3 VGNC VGNC:42582
Rattus norvegicus LAP3 RGD RGD:1307985
Others LAP3 NCBI
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