2. Gene
  3. TMX2 - thioredoxin related transmembrane protein 2 Gene

TMX2 - thioredoxin related transmembrane protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：硫氧还蛋白相关跨膜蛋白 2

种属: Homo sapiens

同用名: PIG26; CGI-31; PDIA12; NEDMCMS; TXNDC14

基因 ID: 51075 | 基因类型: protein coding

关于 TMX2

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,712,593-57,740,973 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 42.0), thyroid (RPKM 36.4) and 25 other tissues.

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有一个 N 端 ER 信号序列、一个具有催化活性的硫氧还蛋白结构域、一个跨膜结构域和一个 C 端 ER 保留序列。这种蛋白质通过两个细胞溶质暴露的半胱氨酸的棕榈酰化在 ER 的线粒体相关膜上富集。[RefSeq 提供，2017 年 1 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This protein is enriched on the mitochondria-associated-membrane of the ER via palmitoylation of two of its cytosolically exposed cysteines. [provided by RefSeq, Jan 2017]

TMX2 基因产物(10)

mRNA Protein Name
NM_001144012.3 NP_001137484.1 thioredoxin-related transmembrane protein 2 isoform 2
NM_001347890.2 NP_001334819.1 thioredoxin-related transmembrane protein 2 isoform 4
NM_001347891.2 NP_001334820.1 thioredoxin-related transmembrane protein 2 isoform 5
NM_001347892.2 NP_001334821.1 thioredoxin-related transmembrane protein 2 isoform 6
NM_001347893.2 NP_001334822.1 thioredoxin-related transmembrane protein 2 isoform 7
NM_001347894.2 NP_001334823.1 thioredoxin-related transmembrane protein 2 isoform 3
NM_001347895.2 NP_001334824.1 thioredoxin-related transmembrane protein 2 isoform 3
NM_001347896.2 NP_001334825.1 thioredoxin-related transmembrane protein 2 isoform 3
NM_001347898.2 NP_001334827.1 thioredoxin-related transmembrane protein 2 isoform 8
NM_015959.4 NP_057043.1 thioredoxin-related transmembrane protein 2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables disulfide oxidoreductase activity IDA
IDA: 通过直接分析推断
31735293 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
31735293 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in brain development IMP
IMP: 通过突变表型推断
31735293 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
31735293 GOA
is active in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: 通过直接分析推断
22045338 GOA
located in mitochondria-associated endoplasmic reticulum membrane contact site IDA
IDA: 通过直接分析推断
31735293 GOA
located in mitochondrion IMP
IMP: 通过突变表型推断
31735293 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMX2 蛋白结构

Thioredoxin

Thioredoxin: Thioredoxin (140 - 230)

  • 0
  • 100
  • 200
  • 296 a.a.
蛋白主名 其他名称

thioredoxin-related transmembrane protein 2

cell proliferation-inducing gene 26 protein

TMX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TMX2 Q9Y320 HSD17B11 Homo sapiens Q8NBQ5
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 HSD17B11 Homo sapiens Q8NBQ5
Y2H Array
32296183
种属内
TMX2 Q9Y320 REEP2 Homo sapiens Q9BRK0
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 REEP2 Homo sapiens Q9BRK0
Y2H Array
32296183
种属内
TMX2 Q9Y320 FAM241B Homo sapiens Q96D05-2
Y2H Array
32296183
种属内
TMX2 Q9Y320 DGAT2L6 Homo sapiens Q6ZPD8
Y2H Array
32296183
种属内
TMX2 Q9Y320 TMEM71 Homo sapiens Q6P5X7-2
Y2H Array
32296183
种属内
TMX2 Q9Y320 TMEM71 Homo sapiens Q6P5X7-2
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 RNF24 Homo sapiens Q9Y225-2
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属内
TMX2 Q9Y320 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
种属内
TMX2 Q9Y320 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
种属内
TMX2 Q9Y320 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
种属内
TMX2 Q9Y320 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
种属内
TMX2 Q9Y320 STATH Homo sapiens P02808
Y2H Array
32296183
种属内
TMX2 Q9Y320 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
种属内
TMX2 Q9Y320 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
种属内
TMX2 Q9Y320 YIPF1 Homo sapiens Q9Y548
Validated Y2H
32296183
种属内
TMX2 Q9Y320 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
种属内
TMX2 Q9Y320 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
种属内
TMX2 Q9Y320 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
种属内
TMX2 Q9Y320 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TMX2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71371 TMX2 Protein, Human (His) Q9Y320-1 (M125-K296) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Microcephaly, Cortical Malformations, And Spasticity

NEDMCMS

Vandervore-Schot Syndrome
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Polymicrogyria

Pmg
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14780 TMX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TMX2 MGD MGI:1914208
Canis familiaris TMX2 VGNC VGNC:52054
Rattus norvegicus TMX2 RGD RGD:1359456
Felis catus TMX2 VGNC VGNC:81104
Bos taurus TMX2 VGNC VGNC:54897
Others TMX2 NCBI
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