2. Gene
  3. ZMYND10 - zinc finger MYND-type containing 10 Gene

ZMYND10 - zinc finger MYND-type containing 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 MYND 型 10

种属: Homo sapiens

同用名: BLU; FLU; CILD22; DNAAF7

基因 ID: 51364 | 基因类型: protein coding

关于 ZMYND10

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,341,112-50,345,732 (from NCBI)

This gene has 9 transcripts (splice variants), 194 orthologues, 2 paralogues and is associated with 3 phenotypes. Restricted expression toward testis (RPKM 91.8).

功能概要

该基因编码一种含有 MYND 型锌指结构域的蛋白质，该结构域可能在动力蛋白马达的组装中发挥作用。该基因的突变可导致原发性纤毛运动障碍。该基因也被认为是肿瘤抑制基因，在癌细胞中经常发生突变、缺失或超甲基化和沉默。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 8 月]

This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in Cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

ZMYND10 基因产物(2)

mRNA Protein Name
NM_001308379.2 NP_001295308.1 zinc finger MYND domain-containing protein 10 isoform 2
NM_015896.4 NP_056980.2 zinc finger MYND domain-containing protein 10 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inner dynein arm assembly IMP
IMP: 通过突变表型推断
23891469 GOA
involved in motile cilium assembly IMP
IMP: 通过突变表型推断
23891469 GOA
involved in outer dynein arm assembly IMP
IMP: 通过突变表型推断
23891469 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZMYND10 蛋白结构

zf-MYND

zf-MYND: MYND finger (394 - 430)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
蛋白主名 其他名称

zinc finger MYND domain-containing protein 10

Ciliary dyskinesia, primary, 22

ZMYND10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZMYND10 O75800 NUTM1 Homo sapiens Q86Y26
Validated Y2H
25416956
Intra ZMYND10 O75800 NUTM1 Homo sapiens Q86Y26
Y2H Prey Pooling
25416956
Intra ZMYND10 O75800 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
Intra ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Y2H Array
32296183
Intra ZMYND10 O75800 SNX11 Homo sapiens Q9Y5W9
Validated Y2H
32296183
Intra ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Validated Y2H
32296183
Intra ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Y2H Array
32296183
Intra ZMYND10 O75800 IFT43 Homo sapiens Q96FT9-2
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Validated Y2H
32296183
Intra ZMYND10 O75800 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra ZMYND10 O75800 CDR1 Homo sapiens P51861
Y2H Array
32296183
Intra ZMYND10 O75800 CDR1 Homo sapiens P51861
Validated Y2H
32296183
Intra ZMYND10 O75800 CDR1 Homo sapiens P51861
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 TBX5 Homo sapiens Q99593
Y2H Array
32296183
Intra ZMYND10 O75800 TBX5 Homo sapiens Q99593
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 TBX5 Homo sapiens Q99593
Validated Y2H
32296183
Intra ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Validated Y2H
32296183
Intra ZMYND10 O75800 EIF3M Homo sapiens Q7L2H7
Y2H Array
32296183
Intra ZMYND10 O75800 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Validated Y2H
32296183
Intra ZMYND10 O75800 WBP1 Homo sapiens Q96G27
Y2H Array
32296183
Intra ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
25416956
Intra ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
25416956
Intra ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Pooling
16189514
Intra ZMYND10 O75800 TSC22D4 Homo sapiens Q9Y3Q8
Pull Down
16189514
Intra ZMYND10 O75800 RBM11 Homo sapiens P57052
Y2H Prey Pooling
32296183
Intra ZMYND10 O75800 RBM11 Homo sapiens P57052
Validated Y2H
32296183
Intra ZMYND10 O75800 RBM11 Homo sapiens P57052
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ciliary Dyskinesia, Primary, 22

Primary Ciliary Dyskinesia 22

CILD22

Primary Ciliary Dyskinesia 22 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 22, With Or Without Situs Inversus

Dyskinesia, Ciliary, Primary, 22
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
Kartagener Syndrome

Kartagener'S Syndrome
Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx

Npc

Nasopharyngeal Cancer

Nasopharyngeal Carcinoma 1

Nasopharynx Carcinoma

Nasopharyngeal Neoplasms

Npca

Carcinoma Of Nasopharynx

Malignant Nasopharyngeal Tumor

Nasopharynx Cancer

Squamous Cell Carcinoma Of The Nasopharynx

Nasopharyngeal Neoplasm

Cancer Of Nasopharynx
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Acute Endometritis
Spondylometaphyseal Dysplasia With Cone-Rod Dystrophy

Spondylometaphyseal Dysplasia-Cone-Rod Dystrophy Syndrome

SMDCRD

Smd-Crd

Dysplasia, Spondylometaphyseal, With Cone-Rod Dystrophy
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16093 ZMYND10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZMYND10 RGD RGD:1303250
Canis familiaris ZMYND10 VGNC VGNC:48650
Felis catus ZMYND10 VGNC VGNC:67263
Mus musculus ZMYND10 MGD MGI:2387863
Bos taurus ZMYND10 VGNC VGNC:37201
Macaca mulatta ZMYND10 VGNC VGNC:79195
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