PDK4 - pyruvate dehydrogenase kinase 4 Gene

中文名称：丙酮酸脱氢酶激酶 4

种属: Homo sapiens

基因 ID: 5166 | 基因类型: protein coding

关于 PDK4

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,583,499-95,596,516 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 4 paralogues. Broad expression in fat (RPKM 319.9), adrenal (RPKM 136.4) and 18 other tissues.

功能概要

该基因是 PDK/BCKDK 蛋白激酶家族的成员，编码具有组氨酸激酶结构域的线粒体蛋白。该蛋白质位于线粒体基质中，通过磷酸化其一个亚基来抑制丙酮酸脱氢酶复合物，从而有助于调节葡萄糖代谢。该基因的表达受糖皮质激素、视黄酸和胰岛素的调节。[RefSeq 提供，2008 年 7 月]

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and Insulin. [provided by RefSeq, Jul 2008]

PDK4 基因产物(1)

mRNA	Protein	Name
NM_002612.4	NP_002603.1	pyruvate dehydrogenase kinase, isozyme 4

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	18658136	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	18658136	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to fatty acid	IMP IMP: 通过突变表型推断	20715114	GOA
involved in cellular response to starvation	IDA IDA: 通过直接分析推断	14966024	GOA
involved in insulin receptor signaling pathway	IMP IMP: 通过突变表型推断	21852536	GOA
involved in negative regulation of anoikis	IMP IMP: 通过突变表型推断	21852536	GOA
involved in reactive oxygen species metabolic process	IMP IMP: 通过突变表型推断	21852536	GOA
involved in regulation of acetyl-CoA biosynthetic process from pyruvate	IMP IMP: 通过突变表型推断	21852536	GOA
involved in regulation of fatty acid biosynthetic process	IMP IMP: 通过突变表型推断	21852536	GOA
involved in regulation of glucose metabolic process	IMP IMP: 通过突变表型推断	21852536	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDK4 蛋白结构

BCDHK_Adom3

HATPase_c

0
100
200
300
411 a.a.

蛋白主名

其他名称

pyruvate dehydrogenase kinase, isozyme 4

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

PDK4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PDK4	Q16654	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
种属内	PDK4	Q16654	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
种属内	PDK4	Q16654	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Rhabdomyosarcoma

Diabetes Mellitus

Diabetes

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-121744	PS10	Inhibitor	99.01%	否
HY-135954A	PDK4-IN-1 hydrochloride		99.51%	否
HY-12492	VER-246608	Inhibitor	99.10%	否
HY-135954	PDK4-IN-1		98.82%	否
HY-114702	M77976	Inhibitor	99.27%	否
HY-139185	PROTAC ERRα Degrader-3	Inhibitor	98.82%	否
HY-156109	PDK-IN-2		/	否
HY-157538	PDK4-IN-2	Inhibitor	/	否
HY-RS10278	PDK4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PDK4	VGNC	VGNC:32706
Felis catus	PDK4	VGNC	VGNC:68777
Macaca mulatta	PDK4	VGNC	VGNC:75935
Mus musculus	PDK4	MGD	MGI:1351481
Rattus norvegicus	PDK4	RGD	RGD:69061
Canis familiaris	PDK4	VGNC	VGNC:44383
Others	PDK4	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PDK4 - pyruvate dehydrogenase kinase 4 Gene

关于 PDK4

功能概要

PDK4 基因产物(1)

PDK4 蛋白结构

PDK4 蛋白互作信息

关联疾病

直系同源

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PDK4 - pyruvate dehydrogenase kinase 4 Gene

关于 PDK4

功能概要

PDK4 基因产物(1)

PDK4 蛋白结构

PDK4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z