STK26 - serine/threonine kinase 26 Gene

中文名称：丝氨酸/苏氨酸激酶 26

种属: Homo sapiens

同用名: MASK; MST4

基因 ID: 51765 | 基因类型: protein coding

关于 STK26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,023,302-132,075,943 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 35 paralogues. Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues.

功能概要

该基因的产物是 GCK III 类激酶家族的成员，是 Ste20 样激酶的一个子集。编码的蛋白质包含一个氨基末端激酶结构域和一个介导同源二聚化的羧基末端调节结构域。蛋白激酶定位于高尔基体，并通过与高尔基体基质蛋白 GM130 结合而被特异性激活。它也在体外被 Caspase-3 切割，并可能在细胞凋亡途径中发挥作用。已经描述了该基因的几种可变剪接的转录本变体，但尚未确定其中一些变体的全长性质。[RefSeq 提供，2008 年 7 月]

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by Caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

STK26 基因产物(3)

mRNA	Protein	Name
NM_001042452.2	NP_001035917.1	serine/threonine-protein kinase 26 isoform 3
NM_001042453.2	NP_001035918.1	serine/threonine-protein kinase 26 isoform 2
NM_016542.4	NP_057626.2	serine/threonine-protein kinase 26 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATP binding	IDA IDA: 通过直接分析推断	11641781	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	11741893	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	11641781	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15037601	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	21561863	GOA
enables protein kinase activity	IDA IDA: 通过直接分析推断	11641781	GOA
enables protein kinase activity	IMP IMP: 通过突变表型推断	22797597	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to oxidative stress	IDA IDA: 通过直接分析推断	22291017	GOA
involved in cellular response to starvation	IMP IMP: 通过突变表型推断	27807006	GOA
involved in intracellular signal transduction	IMP IMP: 通过突变表型推断	22291017	GOA
involved in microvillus assembly	IDA IDA: 通过直接分析推断	22797597	GOA
involved in negative regulation of cell migration	IMP IMP: 通过突变表型推断	27807006	GOA
involved in protein autophosphorylation	IMP IMP: 通过突变表型推断	22797597	GOA
involved in protein phosphorylation	IDA IDA: 通过直接分析推断	11641781	GOA
involved in regulation of apoptotic process	IDA IDA: 通过直接分析推断	11741893	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of FAR/SIN/STRIPAK complex	IDA IDA: 通过直接分析推断	18782753	GOA
located in Golgi apparatus	IDA IDA: 通过直接分析推断	15037601	GOA
located in Golgi-associated vesicle	IDA IDA: 通过直接分析推断	22797597	GOA
located in apical plasma membrane	IDA IDA: 通过直接分析推断	22797597	GOA
located in cell periphery	IDA IDA: 通过直接分析推断	22291017	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17360971	GOA
located in cytosol	IDA IDA: 通过直接分析推断	22797597	GOA
located in membrane	IDA IDA: 通过直接分析推断	27807006	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	22291017	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STK26 蛋白结构

Pkinase

0
100
200
300
416 a.a.

蛋白主名

其他名称

serine/threonine-protein kinase 26

Mst3 and SOK1-related kinase

STK26 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STK26	Q9P289	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	18782753
种属内	STK26	Q9P289	STRIP1	Homo sapiens	Q5VSL9	Pull Down	32707033
种属内	STK26	Q9P289	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	35271311
种属内	STK26	Q9P289	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	35271311
种属内	STK26	Q9P289	CTTNBP2NL	Homo sapiens	Q9P2B4	TAP	23455922
种属内	STK26	Q9P289	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Bait CoIP	18782753
种属内	STK26	Q9P289	CTTNBP2NL	Homo sapiens	Q9P2B4	Pull Down	32707033
种属内	STK26	Q9P289	CTTNBP2NL	Homo sapiens	Q9P2B4	Anti Tag CoIP	18782753
种属内	STK26	Q9P289	CAB39	Homo sapiens	Q9Y376	SPR	21423148
种属内	STK26	Q9P289	CAB39	Homo sapiens	Q9Y376	Anti Tag CoIP	21423148
种属内	STK26	Q9P289	CFTR	Homo sapiens	P13569	Ub Reconstruction	35156780
种属内	STK26	Q9P289	STRN	Homo sapiens	O43815	Anti Bait CoIP	18782753
种属内	STK26	Q9P289	PDCD10	Homo sapiens	Q9BUL8	TAP	23455922
种属内	STK26	Q9P289	PDCD10	Homo sapiens	Q9BUL8	Pull Down	32707033
种属内	STK26	Q9P289	STRN3	Homo sapiens	Q13033	Anti Bait CoIP	18782753
种属内	STK26	Q9P289	STRN	Homo sapiens	O43815	TAP	23455922
种属内	STK26	Q9P289	PDCD10	Homo sapiens	Q9BUL8	Anti Tag CoIP	35271311
种属内	STK26	Q9P289	STRN3	Homo sapiens	Q13033	TAP	23455922
种属内	STK26	Q9P289	PDCD10	Homo sapiens	Q9BUL8	Y2H Array	31515488
种属内	STK26	Q9P289	STRN	Homo sapiens	O43815	Pull Down	32707033
种属内	STK26	Q9P289	STRN3	Homo sapiens	Q13033	Pull Down	32707033
种属内	STK26	Q9P289	PDCD10	Homo sapiens	Q9BUL8	Anti Bait CoIP	18782753
种属内	STK26	Q9P289	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	35271311
种属内	STK26	Q9P289	GOLGA2	Homo sapiens	Q08379	Y2H	15037601
种属内	STK26	Q9P289	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
种属内	STK26	Q9P289	GOLGA2	Homo sapiens	Q08379	Pull Down	32707033
种属内	STK26	Q9P289	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
种属内	STK26	Q9P289	GOLGA2	Homo sapiens	Q08379	Anti Tag CoIP	35271311
种属内	STK26	Q9P289	GOLGA2	Homo sapiens	Q08379	IF	15037601

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 STK26 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74741	MST4/STK26 Protein, Human (sf9, GST)	Q9P289-1 (M1-P416)	≥95%

STK26 抗体

目录号	产品名	应用	反应物种
HY-P83508	MST4 Antibody (YA3253)	WB, ICC/IF, IP	Human, Rat

关联疾病

疾病名称

别名

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13929	STK26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	STK26	VGNC	VGNC:81585
Mus musculus	STK26	MGD	MGI:1917665
Rattus norvegicus	STK26	RGD	RGD:1563568
Canis familiaris	STK26	VGNC	VGNC:46910
Felis catus	STK26	VGNC	VGNC:97648
Bos taurus	STK26	VGNC	VGNC:35392
Others	STK26	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STK26 - serine/threonine kinase 26 Gene

关于 STK26

功能概要

STK26 基因产物(3)

STK26 蛋白结构

STK26 蛋白互作信息

重组 STK26 蛋白

STK26 抗体

关联疾病

直系同源

热门区域

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STK26 - serine/threonine kinase 26 Gene

关于 STK26

功能概要

STK26 基因产物(3)

STK26 蛋白结构

STK26 蛋白互作信息

重组 STK26 蛋白

STK26 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z