1. Gene
  2. STK26 - serine/threonine kinase 26 Gene

STK26 - serine/threonine kinase 26 Gene

中文名称:丝氨酸/苏氨酸激酶 26

种属: Homo sapiens

同用名: MASK; MST4

基因 ID: 51765 | 基因类型: protein coding

关于 STK26

Cytogenetic location: Xq26.2 Genomic coordinates (GRCh38): X:132,023,302-132,075,943 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 35 paralogues. Broad expression in endometrium (RPKM 22.0), bone marrow (RPKM 21.7) and 22 other tissues.

功能概要

该基因的产物是 GCK III 类激酶家族的成员,是 Ste20 样激酶的一个子集。编码的蛋白质包含一个氨基末端激酶结构域和一个介导同源二聚化的羧基末端调节结构域。蛋白激酶定位于高尔基体,并通过与高尔基体基质蛋白 GM130 结合而被特异性激活。它也在体外被 Caspase-3 切割,并可能在细胞凋亡途径中发挥作用。已经描述了该基因的几种可变剪接的转录本变体,但尚未确定其中一些变体的全长性质。[RefSeq 提供,2008 年 7 月]

The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by Caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

STK26 基因产物(3)

mRNA Protein Name
NM_001042452.2 NP_001035917.1 serine/threonine-protein kinase 26 isoform 3
NM_001042453.2 NP_001035918.1 serine/threonine-protein kinase 26 isoform 2
NM_016542.4 NP_057626.2 serine/threonine-protein kinase 26 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
11641781 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11741893 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
11641781 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15037601 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
21561863 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
11641781 GOA
enables protein kinase activity IMP
IMP: 通过突变表型推断
22797597 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
22291017 GOA
involved in cellular response to starvation IMP
IMP: 通过突变表型推断
27807006 GOA
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
22291017 GOA
involved in microvillus assembly IDA
IDA: 通过直接分析推断
22797597 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
27807006 GOA
involved in protein autophosphorylation IMP
IMP: 通过突变表型推断
22797597 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
11641781 GOA
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
11741893 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of FAR/SIN/STRIPAK complex IDA
IDA: 通过直接分析推断
18782753 GOA
located in Golgi apparatus IDA
IDA: 通过直接分析推断
15037601 GOA
located in Golgi-associated vesicle IDA
IDA: 通过直接分析推断
22797597 GOA
located in apical plasma membrane IDA
IDA: 通过直接分析推断
22797597 GOA
located in cell periphery IDA
IDA: 通过直接分析推断
22291017 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17360971 GOA
located in cytosol IDA
IDA: 通过直接分析推断
22797597 GOA
located in membrane IDA
IDA: 通过直接分析推断
27807006 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
22291017 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

STK26 蛋白结构

Pkinase

Pkinase: Protein kinase domain (24 - 274)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase 26

Mst3 and SOK1-related kinase

STK26 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STK26 Q9P289 STRIP1 Homo sapiens Q5VSL9 18782753
种属内
STK26 Q9P289 STRIP1 Homo sapiens Q5VSL9 32707033
种属内
STK26 Q9P289 STRIP1 Homo sapiens Q5VSL9 35271311
种属内
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4 35271311
种属内
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4
TAP
23455922
种属内
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4 18782753
种属内
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4 32707033
种属内
STK26 Q9P289 CTTNBP2NL Homo sapiens Q9P2B4 18782753
种属内
STK26 Q9P289 CAB39 Homo sapiens Q9Y376
SPR
21423148
种属内
STK26 Q9P289 CAB39 Homo sapiens Q9Y376 21423148
种属内
STK26 Q9P289 CFTR Homo sapiens P13569 35156780
种属内
STK26 Q9P289 STRN Homo sapiens O43815 18782753
种属内
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8
TAP
23455922
种属内
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8 32707033
种属内
STK26 Q9P289 STRN3 Homo sapiens Q13033 18782753
种属内
STK26 Q9P289 STRN Homo sapiens O43815
TAP
23455922
种属内
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8 35271311
种属内
STK26 Q9P289 STRN3 Homo sapiens Q13033
TAP
23455922
种属内
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8 31515488
种属内
STK26 Q9P289 STRN Homo sapiens O43815 32707033
种属内
STK26 Q9P289 STRN3 Homo sapiens Q13033 32707033
种属内
STK26 Q9P289 PDCD10 Homo sapiens Q9BUL8 18782753
种属内
STK26 Q9P289 STRN3 Homo sapiens Q13033 35271311
种属内
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
Y2H
15037601
种属内
STK26 Q9P289 GOLGA2 Homo sapiens Q08379 32296183
种属内
STK26 Q9P289 GOLGA2 Homo sapiens Q08379 32707033
种属内
STK26 Q9P289 GOLGA2 Homo sapiens Q08379 32296183
种属内
STK26 Q9P289 GOLGA2 Homo sapiens Q08379 35271311
种属内
STK26 Q9P289 GOLGA2 Homo sapiens Q08379
IF
15037601
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 STK26 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74741 MST4/STK26 Protein, Human (sf9, GST) Q9P289-1 (M1-P416) ≥95%

STK26 抗体

目录号 产品名 应用 反应物种
HY-P83508 MST4 Antibody (YA3253) WB, ICC/IF, IP Human, Rat

关联疾病

疾病名称 别名
Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3

CCM3

Cerebral Cavernous Malformations-3

Cavernous Angiomatous Malformations

Cavernous Hemangioma Of The Brain

Cerebral Capillary Malformations

Cerebral Cavernoma

Familial Cavernous Angioma

Cerebral Cavernous Malformations, Type 3

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome

CCMS

Rib Gap Defects With Micrognathia

Ccm Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta STK26 VGNC VGNC:81585
Mus musculus STK26 MGD MGI:1917665
Rattus norvegicus STK26 RGD RGD:1563568
Canis familiaris STK26 VGNC VGNC:46910
Felis catus STK26 VGNC VGNC:97648
Bos taurus STK26 VGNC VGNC:35392
Others STK26 NCBI